Publications by authors named "Daa Young Kwon"
Background: We aimed to validate a pilot study of photodiagnosis using near infrared (NIR) transillumination and assess the clinical efficacy of hypericin-mediated photodynamic therapy (HYP-PDT) in a rabbit laryngeal cancer model in order to develop a novel therapeutic modality with complete remission and preservation of the functional organ.
Methods: (1) In vitro study: VX tumor cells were subcultured and subjected to HYP-PDT. (2) In vivo study: A laryngeal cancer model was developed in which 12 rabbits were inoculated with a VX tumor suspension in the submucosal area of the left vocal fold using a transoral approach.
Background: The vocal cord tissue consists of three anatomical layers from the surface to deep inside: the epithelium that contains almost no collagen, the lamina propria that is composed of abundant collagen, and the vocalis muscle layer. It is clinically important to visualize the tissue microstructure using a non-invasive method, especially in the case of vocal cord nodules or cancer, since histological changes in each layer of the vocal cord cause changes in the voice. Polarization-sensitive optical coherence tomography (PS-OCT) enables phase retardation measurement to evaluate birefringence of tissue with varied organization of collagen fibers in different tissue layers.
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- Polarization sensitive-optical coherence tomography (PS-OCT) is a technique that uses polarized light to examine the optical properties of tissues, particularly useful for visualizing intercostal muscles under the pleura, where traditional imaging methods fall short.
- This study utilized PS-OCT to detect subpleural cancer in rabbits, injecting cancer cells into the intercostal area and analyzing changes in pleura thickness and muscle damage over 7 to 14 days compared to pathology results.
- The findings suggest that PS-OCT can effectively visualize and assess subpleural cancer, providing valuable structural and functional information that may aid in identifying tumor margins and could lead to advancements in imaging for other diseases.