Nanomedicine-based multimodal therapies: Recent progress and perspectives in colon cancer.

Colon cancer has attracted much attention due to its annually increasing incidence. Conventional chemotherapeutic drugs are unsatisfactory in clinical application because of their lack of targeting and severe toxic side effects. In the past decade, nanomedicines with multimodal therapeutic strategies have shown potential for colon cancer because of their enhanced permeability and retention, high accumulation at tumor sites, co-loading with different drugs, and comb-ination of various therapies.

[Small splint external fixation combined with 3D printing brace for the treatment of Colles fractures].

Objective: To explore the short-term clinical efficacy of manipulation reduction-combined with small splint and 3D printing wrist brace external fixation of wrist brace for Colles fracture and the advantages of using the brace.

Methods: A total of 60 patients with Colles fractures who were treated in Zhongshan Hospital of Traditional Chinese Medicine from February to December 2017 were selected. Patients were randomly divided into 2 groups according to the order of treatment, with 30 patients in the control group, including 13 males and 17 females, aged from 16 to 66 years, with a mean of (49.

[Exposure Level of Population and Economy in Zhejiang Province Considering the Background of PM in East China].

Using the satellite-derived Fine Particulate Matter (PM) data of global high-precision products during 1998-2012, detailed characteristics of PM distribution over East China and its change are given, and the PM exposure levels for population and economy in Zhejiang is further analyzed in this context. The results show that the overall variability of the regional average value of PM concentration exhibits an increasing trend followed by a decrease during 1998-2012, which is consistent in both the East China and Zhejiang provinces; the turning point occurs around 2007-2009. In the initial years (1998-2000), annual average PM concentrations are below 50 μg·m in the southern part of East China and eastern part of Shandong, while it is 50-75 μg·m in other areas.

Prognostic analysis of different morphology of the necrotic-viable interface in osteonecrosis of the femoral head.

Purpose: The purpose of this study was to investigate the collapse progression in different morphologies of the necrotic-viable interface in osteonecrosis of the femoral head (ONFH).

Methods: A total of 168 patients (202 hips) with Association Research Circulation Osseous (ARCO) stage II ONFH were included. Ending with the collapse of the femoral head, all patients received conservative treatment but without surgical intervention and were followed for three to 91 months.

Detecting dopaminergic neuronal degeneration using diffusion tensor imaging in a rotenone-induced rat model of Parkinson's disease: fractional anisotropy and mean diffusivity values.

Dopamine content in the basal ganglia is strongly associated with the degree of dopaminergic neuron loss in the substantia nigra pars compacta. Symptoms of Parkinson's disease might not arise until more than 50% of the substantia nigra pars compacta is lost and the dopamine content in the basal ganglia is reduced by more than 80%. Greater diagnostic sensitivity and specificity would allow earlier detection of Parkinson's disease.

Protective effects of two Lactobacillus plantarum strains in hyperlipidemic mice.

Aim: To investigate the effects of Lactobacillus plantarum (L. plantarum) CAI6 and L. plantarum SC4 on hyperlipidemic mice.

[Spatiotemporal variations of vegetation cover in Zhejiang Province and their relations to eco-climatic indices].

This paper studied the spatiotemporal variations of normalized difference vegetation index (NDVI) in Zhejiang Province in 1982-2006, and their relations to the dominant eco-climatic factors in the Province. In the study period, the vegetation cover in the Province had a slowly decreasing trend, and the area with a significant decrease of NDVI occupied 30.71% of the total.

Anti-tumor activity of polysaccharides isolated from Patrinia scabra Bunge on U14 cervical carcinoma bearing mice.

The aim of our study was to investigate the effect of Patrinia scabra Bunge polysaccharide (PSB-P2) on cervical cancer cell (U14)-bearing mice. The tumor weight of mice treated with PSB-P2 (40, 80 mg/kg b.w.

[Pith decompression of the femoral head and allograft fibula grafting for treatment of avascular necrosis of femoral head].

Objective: To investigate the clinical efficacy of the pith decompression of the femoral head and fibular allograft transplantation in the treatment of early stage avascular necrosis.

Methods: From January 2004 to November 2008, 32 hips of 25 patients with avascular necrosis of femoral head of Ia-IIIb period were treated by the pith decompression of the femoral head and fibular allograft transplantation, hollow lag screw fixation, included 17 males and 8 females, aged from 20 to 55 years old (39.1 years on average).

[Micro-modified Fulkerson osteotomy for the treatment of habituation patellar dislocation].

Objective: To evaluate clinical effect of micro-modified Fulkerson osteotomy under arthroscope in treating habituation patellar dislocation.

Methods: Twenty patients of habituation patellar dislocation (25 knees) were treated by the medial retinaculum plication, lateral retinaculum releasing and modified Fulkerson osteotomy (tibial tubercle anteromedial transfer) under arthroscope. There were 5 males and 15 females with the age from 16- to 28-years-old (average of 21 years).

Antitumor and immunomodulating effects of polysaccharides isolated from Solanum nigrum Linne.

We have examined the effects of the crude polysaccharides isolated from Solanum nigrum Linne (SNL-P) in vitro and in vivo against U14 cervical cancer. SNL-P showed no antiproliferative effects in vitro at a dose up to 1 mg/ml. In vivo administration with SNL-P (90, 180, 360 mg/kg b.

[Effects of rice-duck farming on paddy field's methane emission].

By using closed-chamber technique, the characteristics of CH4 emission from an integrated rice-duck ecosystem were studied in 2006 and 2007. The results showed that comparing with conventional flooded rice ecosystem (CK), integrated rice-duck system (RD) was distinguished in its high dissolved oxygen (DO) in field surface water and significantly lower CH4 emission, due to the activities of duck. In 2006, the average CH4 emission flux and the total CH4 emission during the whole rice growth period of RD were 6.

Antitumor effects of total alkaloids isolated from Solanum nigrum in vitro and in vivo.

This study demonstrated that the total alkaloids isolated from the traditional Chinese medicinal herb Solanum nigrum Linne (SNL-A) inhibited the growth of human cervical cancer HeLa cells in culture medium with much lower toxicity to human normal lymphocytes. By means of HE staining and TUNEL assay, our results further revealed that SNL-A induced cell death by apoptosis. An immunohistochemical assay showed down-regulation of the bcl-2 and p53 genes and no obvious change of bax gene in the SNL-A treated cells.

High-level expression of recombinant human nerve growth factor beta in milk of nontransgenic rabbits.

The technology for the large-scale production of therapeutic recombinant proteins remains a challenge in the biopharmaceutical industry. In this study, we reported a nontransgenic approach to producing a large quantity of human nerve growth factor beta (hNGF-beta) in rabbit milk by employing a recombinant adenoviral expression system. After directly instilling hNGF-beta recombinant adenoviruses into rabbit mammary glands, a polypeptide with a molecular weight of 13.

High-level expression of human lactoferrin in the milk of goats by using replication-defective adenoviral vectors.

The expression of human lactoferrin in the mammary gland is an attractive approach to diminish its current production cost. Previous attempts to produce lactorferrin in the milk of transgenic animals resulted in very high cost and uncertain results. In this paper, we have directly infused replication-defective adenovirus encoding human lactoferrin cDNA into the mammary gland of goats via the teat canal.