Publications by authors named "Da-quan Liu"
Acute respiratory distress syndrome (ARDS) is one of the most devastating complications of sepsis lacking of effective therapy. Mitochondrial dynamics undergoing continuous fusion and fission play a crucial role in mitochondrial structure and function. Fis1, as a small protein located on the outer membrane of mitochondria, has been thought to be an important protein mediated mitochondrial fission.
View Article and Find Full Text PDFBackground: Molecular hydrogen (H2) as a new medical gas has an anti-inflammatory effect. In the present study, we investigated whether heme oxygenase-1 (HO-1) contributes to the anti-inflammatory effect of H2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
View Article and Find Full Text PDFHeme oxygenase (HO)-1 has been reported to play a great role in attenuating lung injury during endotoxic shock in our previous research. Although electro-acupuncture has been explored to reduce oxidative stress and decrease inflammatory reaction in animals with endotoxic shock, the mechanism of this effect is still unclear. The aim of this study was to determine whether HO-1 is involved in the effect of electro-acupuncture on the injured lung during endotoxic shock in rabbits.
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- The study aimed to investigate the effects of probiotics on survival rates in septic rats induced by cecal ligation and puncture.
- Probiotics treatment significantly increased the survival of septic rats in a dose-dependent manner, with higher doses leading to better outcomes compared to the control group.
- The treatment also resulted in reduced bacterial counts in the blood and ascites, particularly for harmful bacteria like Escherichia coli and Staphylococcus aureus, and reduced inflammation in intestinal tissues.
The posttranscriptional regulation of miRNAs is important for organism development. To investigate the role of miRNAs in angiogenesis, we performed a loss-of-function screening assay in human umbilical vein endothelial cells (HUVECs) and found that knockdown of 7 miRNAs (miR-95a, miR-126, miR-129, miR-137, miR-139, miR-200a, and miR-335) significantly suppressed cell viability. As miR-200a was highly expressed in HUVECs, blocking endogenous miR-200a using 2'-OMe antisense oligonucleotide (ASOs) resulted in a decrease of cell viability and migration.
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- The study aimed to evaluate the effectiveness of HE staining versus enzyme histochemical staining in assessing the viability of hepatocellular carcinoma (HCC) cells after microwave ablation at different temperatures.
- Two groups of mice with transplanted HCC were treated with microwave ablation at 60°C and 50°C, and tissue samples were analyzed before and after the procedure using both staining methods.
- Results showed that while HE staining revealed no significant changes in cell morphology, enzyme histochemical staining indicated complete cell death at 60°C and some surviving cells at 50°C, highlighting the superiority of enzyme staining for assessing tumor cell viability post-ablation.