Publications by authors named "Da-hai Zhou"
Article Synopsis
- The study investigates the genetic mutations of the VHL tumor-suppressor gene in a Chinese family with non-syndromic pheochromocytomas (PCCs) and individuals with sporadic PCCs (ASP).
- DNA samples were analyzed from 20 family members and 41 ASP patients, revealing three novel mutations in the VHL gene, all associated with specific types of VHL syndrome.
- The findings suggest that these mutations impair pVHL function, aiding in early diagnosis and treatment of Von Hippel-Lindau syndrome and advancing research on its underlying causes.
[Genetic detection and analysis of the VHL gene in patients with sporadic pheochromocytoma].
Zhonghua Zhong Liu Za Zhi
May 2009
Article Synopsis
- - The study aimed to analyze the VHL gene in 41 Chinese patients with sporadic pheochromocytoma by extracting DNA from blood and tumor samples, comparing it to DNA from 50 healthy individuals.
- - Genetic testing revealed significant mutations in the VHL gene, including a mutation at nucleotide 572 and frameshift mutations from two small insertions, with some family members also carrying these mutations.
- - The findings suggest that genetic testing for VHL mutations should be routine for patients under 50 with sporadic pheochromocytoma, as it could help diagnose hereditary forms of the condition.
[Mutation screening of VHL gene in a Chinese family with nonsyndromic pheochromocytoma].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
August 2007
Objective: To detect the VHL gene mutations in a Chinese family with nonsyndromic pheochromocytoma.
Methods: Mutations of VHL gene were detected in a Chinese family with nonsyndromic pheochromocytoma. Five patients and fifteen relatives were involved in this study.