Publications by authors named "Da-Yang Chen"
Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic-Ischemic Encephalopathy.
Diagnostics (Basel)
November 2021
Article Synopsis
- Identifying biomarkers for hearing impairments (HIs) in neonates with hypoxic-ischemic encephalopathy (HIE) is essential for early intervention, with a significant proportion showing HIs compared to non-HIE newborns (14.1% vs. 0.87%).
- Among the 78 HIE patients studied, moderate-to-severe cases had a higher incidence of HIs, and factors like clinical staging and blood levels of lactate and glucose were linked to these impairments.
- The severity of HIs in infants with HIE correlated with brain anomalies and developmental outcomes at one year, highlighting the importance of monitoring clinical indicators for predicting hearing health.
Article Synopsis
- Research using single-cell low-coverage whole genome sequencing (SLWGS) shows improved detection of copy number variations (CNVs) due to factors like whole genome amplification (WGA) methods and sequencing platforms.
- In this study, two WGA kits were compared on the HiSeq2000 and Ion Proton platforms, revealing differences in reproducibility, error rates, and GC-bias based on the chosen kit and sequencing platform.
- The findings aid researchers in selecting the best experimental conditions for SLWGS when working with single or multiple cells, depending on their specific needs for sensitivity and specificity in CNV detection.
The complete mitochondrial genome of the Monterrey platyfish (Xiphophorus couchianus).
Mitochondrial DNA A DNA Mapp Seq Anal
November 2016
The Monterrey platyfish (Xiphophorus couchianus) is native to the vicinity of Monterrey, Mexico and is listed as Critically Endangered by International Union for Conservation of Nature (IUCN). Here, we describe the complete mitochondrial genome (mitogenome) sequence of Monterrey platyfish. The genome is 16 638 bp in length, consisting of 13 protein-coding genes, 22 transfer RNA (tRNA) genes, 2 ribosomal RNA genes and 1 non-coding control region.
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