Publications by authors named "Da-Yan Hu"
Article Synopsis
- Largemouth bass iridovirus (LMBV) poses significant threats to largemouth bass farming, resulting in high mortality and substantial economic losses, with no effective treatments available.
- Researchers developed a recombinant version of the major capsid protein of LMBV and administered it orally to largemouth bass, measuring the resulting immune responses through various tests.
- The study found that immunized fish exhibited significantly higher antibody levels and improved survival rates against LMBV, suggesting that the recombinant vaccine has strong potential to protect largemouth bass from this virus.
Background: The tumor suppressor gene CDC73 was found to be associated with hyperparathyroidism-jaw tumor syndrome (HPT-JT), which is characterized by parathyroid adenoma or carcinoma, ossifying fibroma (OF) of the jaws, and renal and uterine lesions. Mutations in CDC73 have also been frequently detected in sporadic parathyroid carcinomas and renal tumors. However, the prevalence and range of CDC73 mutations in sporadic OFs have not been established.
View Article and Find Full Text PDFBackground: Genome-wide association studies (GWASs) have revealed a large number of genetic risk loci for many autoimmune diseases. One clear finding emerging from the published genetic studies of autoimmunity is that different autoimmune diseases, such as psoriasis and systemic lupus erythematosus (SLE), share susceptibility loci. Our study explores additional susceptibility loci shared by psoriasis and SLE in the Chinese Han population.
View Article and Find Full Text PDFVitiligo is an acquired pigmentary disorder characterized by loss of epidermal melanocytes. A strong association at a single nucleotide polymorphism (SNP) rs11966200 within MHC region had been identified in a recent genome-wide association study of generalized vitiligo in Chinese Han population. This study aims to investigate the relationships between SNP rs11966200 and the clinical features of generalized vitiligo in Chinese Han population.
View Article and Find Full Text PDFTo identify susceptibility loci for vitiligo, we extended our previous vitiligo genome-wide association study with a two-staged replication study that included 6,857 cases and 12,025 controls from the Chinese Han population. We identified three susceptibility loci, 12q13.2 (rs10876864, P(combined)=8.
View Article and Find Full Text PDFPsoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis. PSOR1 locus (6q21) has been strongly associated with psoriasis; however, it is difficult to identify additional independent association due to strong linkage disequilibrium in the MHC region. We performed stepwise regression analyses of more than 3,000 SNPs in the MHC region genotyped using Human 610-Quad (Illumina) in 1,139 cases with psoriasis and 1,132 controls of Han Chinese population to search for additional independent association.
View Article and Find Full Text PDFGenome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population.
Nat Genet
June 2011
Article Synopsis
- Atopic dermatitis is a long-lasting inflammatory skin condition influenced by both genetics and the environment.
- A study involved a genome-wide analysis of atopic dermatitis in a large Chinese Han population and included additional samples from Germany, leading to the identification of new genetic markers associated with the condition.
- The findings reveal new potential genetic factors that contribute to atopic dermatitis and suggest new biological pathways that could be explored for better understanding and treatment.
Article Synopsis
- - We conducted a genome-wide association study for generalized vitiligo focusing on the Chinese Han population, involving over 1,100 cases and almost 1,500 controls, followed by a larger replication study in different Chinese populations.
- - Two significant genetic markers in the major histocompatibility complex (MHC) region were identified, one associated with increased risk (rs11966200) and another potentially protective (rs9468925) related to specific HLA alleles.
- - Additionally, we discovered a new risk locus at 6q27 (rs2236313) linked to three genes, contributing to a better understanding of the genetic factors involved in vitiligo.
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
Nat Genet
November 2009
Article Synopsis
- A genome-wide association study (GWAS) was conducted on systemic lupus erythematosus (SLE) in a Chinese Han population, involving over 1,000 cases and 1,200 controls, with genetic analysis performed using Illumina technology.
- The study identified nine new genetic susceptibility loci for SLE and confirmed seven previously known loci, showing a significant difference in genetic factors contributing to SLE between Chinese Han and European populations.
- Findings from this research enhance the understanding of SLE's genetic basis and emphasize the importance of studying diverse populations in genetic research.