Publications by authors named "Da-Xian Wu"
Article Synopsis
- Acute-on-chronic liver failure (ACLF) and decompensated cirrhosis (DC) are severe complications of chronic hepatitis B virus (HBV) infection, marked by metabolic disturbances in the liver and beyond.
- A study analyzed serum samples and liver tissues from patients with HBV-ACLF, HBV-DC, and control groups to explore metabolic changes, highlighting impairments in energy, amino acid, and pyrimidine metabolism specific to ACLF/DC.
- The research found that both conditions share similar abnormal serum metabolite profiles linked to inflammation and metabolic dysfunction, with unique markers for each, suggesting a connection between liver pathology and systemic inflammatory response.
Serum levels of miRNA in patients with hepatitis B virus-associated acute-on-chronic liver failure.
Hepatobiliary Pancreat Dis Int
April 2018
Background: Hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) is a life-threatening condition and its exact pathophysiology and progression remain unclear. The present study aimed to assess the role of serum miRNAs in the evaluation of HBV-ACLF and to develop a model to predict the outcomes for ACLF.
Methods: Serum was collected from 41 chronic hepatitis B and 55 HBV-ACLF patients in addition to 30 chronic asymptomatic HBV carriers as controls.
Novel HBV mutations and their value in predicting efficacy of conventional interferon.
Hepatobiliary Pancreat Dis Int
April 2017
Background: Accumulating studies assessing the impacts of hot spot mutations on conventional interferon (IFN) efficacy come to discrepant conclusions; studies regarding the mutations in S and RT regions are also unclear. The present study aimed to evaluate the impacts of HBV mutations on the efficacy of conventional IFN.
Methods: A total of 126 patients who received conventional IFN treatment for 48 weeks were enrolled.