Publications by authors named "Da-Tian Wang"

Background: The abdominal perineal resection (APR), historically referred to as Mile's procedure, stands as a time-honored surgical intervention for rectal cancer management. Advancements in surgical techniques and the advent of neoadjuvant therapies have significantly improved the rate of sphincter preservation among patients afflicted with rectal cancer, including those with ultralow rectal cancer. Despite these improvements, APR maintains its irreplaceable role in the clinical landscape, particularly for cases involving low rectal cancer with encroachment on the external anal sphincter or levator ani muscles.

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Article Synopsis
  • There is a significant gap in understanding how immune characteristics are linked to gastrointestinal tract cancers, making further research crucial for developing immunotherapy targets.
  • A two-sample Mendelian randomization analysis was performed, utilizing data from GWAS Catalog and the FinnGen database to assess 731 immune traits and their relationship with various gastrointestinal cancers.
  • The study identified 78 immune traits that are causally linked to gastrointestinal cancers, with additional findings showing 60 traits act as protective factors, highlighting specific immune traits that may influence cancer risk across multiple locations.
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