Defluorinative Diazolation-Cyclization Relay for Synthesis of Furan-Bridged Triheterocycles and Colorimetric Sensor Application.

Polyaromatics, as the assembly of diverse cyclic π-systems, exhibit unique physicochemical properties when compared to their individual constituents. In this study, we developed a strategic connection of two azacycles via a furan bridge through a defluorinative diazolation-cyclization reaction of trifluoromethyl enones and N-heterocycles. A range of modular 2,4-furan-bridged triheterocycles (FBTHs), featuring a C3-trifluoromethyl group, was synthesized with broad substrate scope and good regioselectivity under transition metal-free conditions.

Epidemiological features and viral shedding in children with SARS-CoV-2 infection.

A pandemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection broke out all over the world; however, epidemiological data and viral shedding in pediatric patients are limited. We conducted a retrospective, multicenter study, and followed-up with all children from the families with SARS-CoV-2 infected members in Zhejiang Province, China. All infections were confirmed by testing the SARS-CoV-2 RNA with real-time reverse transcription PCR method, and epidemiological data between children and adults in the same families were compared.

Blood species identification based on deep learning analysis of Raman spectra.

Blood analysis is an indispensable means of detection in criminal investigation, customs security and quarantine, anti-poaching of wildlife, and other incidents. Detecting the species of blood is one of the most important analyses. In order to classify species by analyzing Raman spectra of blood, a recognition method based on deep learning principle is proposed in this paper.

FRS: A simple knowledge graph embedding model for entity prediction.

Entity prediction is the task of predicting a missing entity that has a specific relation-ship with another given entity. Researchers usually use knowledge graphs embedding(KGE) methods to embed triples into continuous vectors for computation and perform the tasks of entity prediction. However, KGE models tend to use simple operations to refactor entities and relationships, resulting in insufficient interaction of components of knowledge graphs (KGs), thus limiting the performance of the entity prediction model.

Corrigendum: Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis Nrf2 Signaling.

[This corrects the article DOI: 10.3389/fphar.2018.

Correction to: Isoliquiritigenin Provides Protection and Attenuates Oxidative Stress-Induced Injuries via the Nrf2-ARE Signaling Pathway After Traumatic Brain Injury.

The original version of this article unfortunately contained a mistake. The Fluorescence Immunoassays text written in Materials and Methods section and Fig. 1i, j is incorrect.

Isoliquiritigenin Provides Protection and Attenuates Oxidative Stress-Induced Injuries via the Nrf2-ARE Signaling Pathway After Traumatic Brain Injury.

Traumatic brain injury (TBI) is a serious public health and medical problem worldwide. Oxidative stress plays a vital role in the pathogenesis of TBI. Nuclear factor erythroid 2-related factor 2 (Nrf2), an important factor in the cellular defense against oxidative stress, is activated following TBI.

Isoliquiritigenin protects against blood‑brain barrier damage and inhibits the secretion of pro-inflammatory cytokines in mice after traumatic brain injury.

Traumatic brain injury (TBI) caused by an external mechanical force acting on the brain is a serious neurological condition. Inflammation plays an important role in prolonging secondary tissue injury after TBI, leading to neuronal cell death and dysfunction. Isoliquiritigenin (ILG) is a flavonoid monomer with anti-inflammatory characteristic.

Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling.

Severe acute pancreatitis (SAP) is a digestive system disease that is associated with a range of complications including intestinal dysfunction. In this study, we determined that the chalcone compound, isoliquiritigenin (ISL), reduces pancreatic and intestinal injury in a mouse model of SAP. These effects were achieved by suppressing oxidative stress and the inflammatory responses to SAP.

Regulation of Caveolin-1 and Junction Proteins by bFGF Contributes to the Integrity of Blood-Spinal Cord Barrier and Functional Recovery.

The blood-spinal cord barrier (BSCB) plays important roles in the recovery of spinal cord injury (SCI), and caveolin-1 is essential for the integrity and permeability of barriers. Basic fibroblast growth factor (bFGF) is an important neuroprotective protein and contributes to the survival of neuronal cells. This study was designed to investigate whether bFGF is beneficial for the maintenance of junction proteins and the integrity of the BSCB to identify the relations with caveolin-1 regulation.

bFGF Protects Against Blood-Brain Barrier Damage Through Junction Protein Regulation via PI3K-Akt-Rac1 Pathway Following Traumatic Brain Injury.

Many traumatic brain injury (TBI) survivors sustain neurological disability and cognitive impairments due to the lack of defined therapies to reduce TBI-induced blood-brain barrier (BBB) breakdown. Exogenous basic fibroblast growth factor (bFGF) has been shown to have neuroprotective function in brain injury. The present study therefore investigates the beneficial effects of bFGF on the BBB after TBI and the underlying mechanisms.

Analysis of posttraumatic stress disorder in children with road traffic injury in Wenzhou, China.

Objective: Road traffic accidents are the leading health threat to children and cause significant long-term mental health problems. This study aimed to characterize posttraumatic stress disorder (PTSD) in children suffering from road traffic injuries (RTIs) in Wenzhou, China.

Methods: We conducted a retrospective study of 537 children (aged 1 to 13 years old) with RTIs.

[Effects of surgically implanted dummy ultrasonic transmitters on grass carp Ctenopharyngodon idella].

In order to study the effects of surgically implanted dummy ultrasonic transmitters on grass carp Ctenopharyngodon idella, two experiments were conducted from October 2010 to December 2010 and November 2010 to October 2011. The results showed that surgical implantation of dummy ultrasonic transmitters had a significant negative influence on the growth of grass carp within 30 days following the surgery. However, the negative influence after 30 days faded away.

Mitochondrial genome of silver gudgeon, Squalidus argentatus (Teleostei, Cypriniformes).

In this paper, we first determined the complete mitochondrial genome sequence of Squalidus argentatus, which was 16,607 bp in size and the whole base composition was estimated to be 30.48% A, 25.45% T, 27.

Mitochondrial genome of the flat-lip gudgeon, Platysmacheilus exiguus (Teleostei, Cypriniformes).

The complete mitogenome of an endemic fish in China flat-lip gudgeon, Platysmacheilus exiguous, was determined using the polymerase chain reaction and directly sequenced with the primer walking method. The whole mitogenome was 16,604 bp in length, consisting of 13 protein-coding genes, 22 transfer RNA (tRNA) genes, 2 ribosomal RNA (rRNA) genes and 1 control region. It had the typical circular molecule structure of vertebrate's mitogenome.

[Analysis of influencing factors of transient hypothyroxinemia and low T3 syndrome in premature infants].

Objective: To investigate the influencing factors of transient hypothyroxinemia (THT) and low T3 syndrome (LT3S) in premature infants.

Method: We have studied 418 premature infants whose gestational age was between 26 and 36 weeks.Serum thyronine (T4), triiodothyronine (T3) and thyrotropin (TSH) of them were detected on the fourteenth day approximately after birth.

Complete mitochodrial genome of the redlip loach Leptobotia rubrilaris (Teleostei, Cypriniformes: Cobitidae).

In this study, the complete mitochondrial genome sequence of the Leptobotia rubrilaris has been obtained. The genome includes 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes and a non-coding control region with the total length of 16,585 bp. The gene arrangement and composition were identical to other vertebrate.

Complete mitochondrial genome of the smallscale yellowfin, Plagiognathops microlepis (Teleostei: Cypriniformes: Cyprinidae).

The smallscale yellowfin, Plagiognathops microlepis is the only one species in the genus Plagiognathops. In this study, we sequenced the complete mitochondrial genome of the P. microlepis.

[Age structure and genetic diversity of Homatula pycnolepis in the Nujiang River basin].

This study examined the age structure of the Loach, Homatula pycnolepis through the otolith growth rings in 204 individual specimens collected from the Xiaomengtong River of the Nujiang River (Salween River) basin in April, 2008. There were only two different age classes, 1 and 2 years of age-no 3 year olds were detected. The age structure of H.

[Effects of transmitter's surgical implantation on fish: research progress].

Surgical implantation is generally accepted as the preferred attachment method for longterm fish telemetry study, but the negative effects of this surgical implantation on fish should not be ignored. The key for the successful fish telemetry study is that the existence and attachment of the transmitters in the experimental fish would not have negative effects on the normal fish physiology or behavior. Therefore, it is necessary to assess the potential negative effects of surgical implantation of transmitter on experimental fish prior to telemetry monitoring.