Publications by authors named "Da-Na Lee"
Article Synopsis
- The study investigated how different types of octacalcium phosphate (OCP) particles and collagen membranes affect new bone formation and volume maintenance in rabbit skull defects.
- Results showed that the group with 76% OCP particles had more new bone volume after 2 weeks than the 90% OCP group, with significant differences noted in bone ratios.
- By 8 weeks, all experimental groups showed increased new bone area, with the 90% OCP group (without a membrane) showing less residual graft volume, indicating OCP can be an effective and biocompatible bone graft material regardless of density or membrane use.
Purpose: The aim of this study was to investigate the efficacy of photo-crosslinked gelatin methacryloyl (GelMa) hydrogel containing calcium phosphate nanoparticles (CNp) when applying different fabrication methods for bone regeneration.
Methods: Four circular defects were created in the calvaria of 10 rabbits. Each defect was randomly allocated to the following study groups: 1) the sham control group, 2) the GelMa group (defect filled with crosslinked GelMa hydrogel), 3) the CNp-GelMa group (GelMa hydrogel crosslinked with nanoparticles), and 4) the CNp+GelMa group (crosslinked GelMa loaded with nanoparticles).
Background: Biphasic calcium phosphate (BCP) is the most frequently used synthetic bone substitutes, which comprises a combination of hydroxyapatite (HA) and beta-tricalcium phosphate (b-TCP). Thanks to the recent advances in digital dentistry and three-dimensional (3D) printing technology, synthetic block bone substitutes can be customized to fit individual defect morphologies. The diameter of the pores can influence the rate of bone formation and material resorption.
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