Huan Jing Ke Xue
January 2025
In this investigation, the influence of organic amendment on the structural and functional dynamics of soil microbial communities and its effect on rice productivity were examined. Five fertilization treatments from a 40-year field experiment were selected: no fertilizer (CK), inorganic NPK fertilizer (NPK), inorganic NPK combined with green manure (NG), inorganic NPK combined with green manure and pig manure (NGM), and inorganic NPK combined with green manure and rice straw (NGS). The findings revealed that the organic amendment enhanced the soil organic carbon (SOC), total nitrogen (TN), and total phosphorus (TP) levels, alongside an increase in rice yield; notably, the most significant improvements were observed with the NGM treatment.
View Article and Find Full Text PDFIntroduction: The aim of the study was to construct folic acid-modified PEGylated paramagnetic nanoparticles (MNPs) co-carrying tissue factor pathway inhibitor-2 (TFPI-2) and cisplatin (CDDP), and to study the molecular-targeting and inhibitory effects of the nanocomposite on non-small cell lung cancer (NSCLC) and liver cancer.
Methods: Nanocomposites were prepared using amino-modified iron oxide nanoparticles as carriers, co-loading CDDP and PEGylated FA/TFPI-2. Transmission electron microscopy, UV absorption spectrum, and dynamic light scattering were employed to characterize the morphology, structure, particle size, and zeta potential of the nanocomposite.
Proc Natl Acad Sci U S A
September 2019
Genome-wide phenotypic screens provide an unbiased way to identify genes involved in particular biological traits, and have been widely used in lower model organisms. However, cost and time have limited the utility of such screens to address biological and disease questions in mammals. Here we report a highly efficient () transposon-based first-generation (F1) dominant screening system in mice that enables an individual investigator to conduct a genome-wide phenotypic screen within a year with fewer than 300 cages.
View Article and Find Full Text PDFWe aimed to explore changes in basic soil productivity (BSP) under different fertilization regimes in the Poyang Lake region, Jiangxi Province, China. Soil samples were collected from a long-term fertilization experiment (since 1981) that included treatments of no fertilization (CK), chemical fertilization (NPK), and combined chemical and organic fertilization (NPKM). Then, a three-year pot experiment (from 2012 to 2014) with double rice cropping was conducted with two different fertilization regimes (no fertilization, F; fertilization, F) using CK, NPK and NPKM soils.
View Article and Find Full Text PDFMultiple signalling events interact in cancer cells. Oncogenic Ras cooperates with Egfr, which cannot be explained by the canonical signalling paradigm. In turn, Egfr cooperates with Hedgehog signalling.
View Article and Find Full Text PDFIn the present study, the eutrophic level of 30 water samples collected from Lake hongze in August 2014 were analyzed, and the abundance of toxic and non-toxic Microcystis sp., together with their spatial distribution, was investigated by quantitative real-time PCR techniques. The results showed that the average concentrations of total nitrogen and total phosphorus were 1.
View Article and Find Full Text PDFColorectal cancer is one of the most serious illnesses among diagnosed cancer. As a new type of anti-cancer composition from tocotrienol-rich fraction of palm oil, γ-tocotrienol is widely used in anti-cancer research. The objectives of this study were to investigate the effects of γ-tocotrienol on human colon cancer SW620 and HCT-8 cells.
View Article and Find Full Text PDFZhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
April 2012
Objective: To understand the status of schistosomiasis knowledge and behavior and analyze the regional difference of population in Mianzhu City.
Methods: Nine towns were divided into 3 groups, and each group had 3 towns. In Group I , there were 5 or more than 5 advanced schistosomiasis patients each town; in Group II , there were 1-4 advanced patients each town; in Group III, there was no advanced patient.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
December 2011
After "5.12" earthquake, 5 128 reconstruction people from schistosomiasis endemic areas were surveyed for schistosome infection from 2009 to 2001. There were 261 seropositive persons with the positive rate of 5.
View Article and Find Full Text PDFTocotrienol is considered a beneficial effect agent on inhibition of tumor development. In this study, we focused on the effects of δ-tocotrienol and its possible mechanism on induction of death in human colon cancer SW620 cells. δ-Tocotrienol inhibited proliferation of SW620 cell in a dose-dependent manner.
View Article and Find Full Text PDFLATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. LATS1 inhibits both the phosphorylation of cofilin by LIMK1 and LIMK1-induced cytokinesis defects.
View Article and Find Full Text PDFElevated Src protein levels and activity are associated with the development and progression of a variety of cancers. The consequences of deregulated Src activity have been studied extensively in cell culture; however, the effects of this deregulation in vivo, as well as the mechanisms of Src-induced tumorigenesis, remain poorly understood. In this study, the effect of expressing wild-type and constitutively active Drosophila Src-family kinases (SFKs) in the developing eye was examined.
View Article and Find Full Text PDFDisrupting mechanisms that control cell proliferation, cell size and apoptosis can cause changes in animal and tissue size and contribute to diseases such as cancer. The LATS family of serine/threonine kinases control tissue size by regulating cell proliferation and function as tumor suppressor genes in both Drosophila and mammals. In order to understand the role of lats in size regulation, we performed a genetic modifier screen in Drosophila to identify components of the lats signaling pathway.
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