Purpose: This study aimed to evaluate the effects of curcumin by co-administration of arsenic trioxide (AsO) in acute myeloid leukemia (AML) treatment, using network pharmacology and experimental validation.
Methods: Using Pubchem database, Traditional Chinese Medicine Information Database (TCMID) database, and Swiss target prediction database to predict compound-related targets, AML-associated targets were determined using GeneCards and Online Mendelian Inheritance in Man (OMIM) databases. We identify overlapping common targets by comparing Compounds-related and AML-associated targets and using these targets to perform GO and KEGG functional enrichment analyses.