Publications by authors named "Da-Kui Li"
Genome-wide analysis of long non-coding RNAs involved in the fruit development process of Baogua.
Physiol Mol Biol Plants
September 2024
Article Synopsis
- The study focuses on the Baogua melon, which is ideal for research on fruit development due to its adaptability to various climates.
- Researchers sequenced the transcriptome of the Baogua melon at three development stages (14, 21, and 28 days) to explore the role of long non-coding RNAs (lncRNAs) in this process.
- They identified 1716 high-confidence lncRNAs and discovered 388 that were differentially expressed, providing insights into the regulatory mechanisms of lncRNAs in melon fruit development.
Background: Guideline development should be based on the quality of evidence, balance of benefits and harms, economic evaluation and patients' views and preferences. Therefore, these factors were considered in the development of a new guideline for therapeutic drug monitoring (TDM) of vancomycin.
Objectives: To develop an evidence-based guideline for vancomycin TDM and to promote standardized vancomycin TDM in clinical practice in China.
Background: Of the enzymes involved in the metabolism of azathioprine, thiopurine methyltransferase (TPMT) is the one characterized by genetic polymorphisms and ethnic variations. There have been several studies of the ethnic variations in phenotype and genotype of TPMT, although few have assessed the possible correlation between TPMT activity and 6-thioguanine nucleotide (6-TGN) concentrations.
Objective: The aim of this study was to examine the relationship between TPMT activity and the steady-state concentration (Css) of 6-TGN, the primary active metabolite of azathioprine, in red blood cells (RBCs) in Han Chinese patients treated with azathioprine.
Aim: To study the pharmacokinetics and relative bioavailability of salbutamol metered-dose inhaler (MDI) in healthy volunteers.
Methods: An HPLC method for the determination of salbutamol in human plasma was improved. Ten healthy male Chinese volunteers were enrolled in a randomized crossover study.