Publications by authors named "Da-Jin Pi"
[Kaixin San ameliorating doxorubicin-induced neurotoxicity by activating AMPK signaling pathway].
Zhongguo Zhong Yao Za Zhi
December 2024
The study explored the pathological mechanism of doxorubicin chemotherapy-induced neurotoxicity and the intervention methods of traditional Chinese medicine. BALB/c mice were selected to establish tumor-bearing mouse models by orthotopic injection of 4T1 triple-negative breast cancer cells. After randomization, the mice were treated with doxorubicin chemotherapy or doxorubicin chemotherapy + Kaixin San(KXS).
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- The study investigates the effects of Kaixin Powder (KXP) on behavior and brain tissue in mice undergoing chemotherapy to understand how it may reduce cognitive impairment related to cancer treatment.
- Thirty female BALB/c mice with breast cancer were divided into three groups for testing, including behavioral assessments and various pathological examinations to evaluate the impact of KXP compared to chemotherapy.
- Results showed that KXP significantly improved behavior and cognition in mice, reduced neuroinflammation and cell death in the brain, and altered RNA expression profiles, suggesting its potential to mitigate cognitive damage during chemotherapy.