Relationship between clarithromycin MICs and treatment responses in Mycobacterium avium complex pulmonary disease.

Background: Mycobacterium avium complex pulmonary disease (MAC-PD) is a chronic lung condition with rapidly increasing prevalence worldwide. Macrolides like azithromycin and clarithromycin are the backbone of long-term antibiotic therapy for progressive MAC-PD. The impact of minimum inhibitory concentrations (MICs), especially within the susceptible range, for macrolides on treatment responses remains unclear.

Work productivity and activity impairment in gastroesophageal reflux disease in Korean full-time employees: a multicentre study.

Introduction: The costs of gastroesophageal reflux disease have not been assessed in Asia, even though the prevalence of gastroesophageal reflux disease is gradually increasing. We evaluated work presenteeism and absenteeism as indirect costs of gastroesophageal reflux disease in Korea.

Methods: This was a cross-sectional and multicentre study using patient-reported outcome instruments.