Clinical implementation of Nephrologist-led Genomic Testing for Glomerular Diseases in Singapore: Rationale and Protocol.

Introduction The early diagnosis and appropriate treatment of monogenic glomerular diseases can reduce kidney failure, avoid unnecessary investigations such as kidney biopsies and ineffective treatment with immunosuppressants, guide transplant decisions, and inform the genetic risks of their family members. Yet, genetic testing for kidney disease is under-utilized in Singapore. We aimed to implement a nephrologist-led genetic service and evaluate the acceptance, adoption, utility and cost-effectiveness of genetic testing for monogenic glomerular disease in Singapore.

The Mediated Moderation of Conscientiousness and Active Involution on Zhongyong Practical Thinking and Depression.

Purpose: This study integrates traditional Chinese culture, precisely the philosophy of Zhongyong () thinking, with the prevention and treatment of depression.

Samples And Methods: It involved a study with 700 undergraduate students from a college in Guangzhou, using the Negative Zhongyong Scale, the Patient Health Questionnaire-9, and the NEO Five-Factor Inventory for assessments.

Results: The findings demonstrated that negative Zhongyong thinking predicts depression inversely.

Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease.

Macrophage activation syndrome (MAS) is a potentially fatal consequence of adult-onset Still's disease (AOSD), driven by a cytokine storm. Efficient early diagnosis of AOSD-associated MAS requires a sensitive and specific biomarker. In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD disease activity and served as a biomarker for AOSD-MAS.

Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still's disease.

Background: Adult-onset Still's disease (AOSD) is a systemic autoinflammatory disease characterized by innate immune system activation, with a high risk for macrophage activation syndrome (MAS). MAS development is associated with monocyte/macrophage activation and cytokine storm. Monocytes consist of three different subsets, classical monocytes (CMs, CD14CD16 -), intermediate monocytes (IMs, CD14CD16 +), and non-classical monocytes (NCMs, CD14CD16 +), each has distinct roles in inflammatory regulation.

Model construction for height to crown base of based on mixed-effects model and quantile regression.

Height to crown base is an important index reflecting the characteristics of tree crown. It is of great significance to accurately quantify height to crown base for forest management and increasing stand production. We used nonlinear regression to construct the height to crown base generalized basic model, and further extended that to the mixed-effects model and quantile regression model.

Validity evaluation of teacher's core literacy questionnaire of public physical education.

Objective: The purpose of this study was to develop a core literacy questionnaire for public physical education teachers in colleges and universities (TCLQ-PPE) to address the current lack of core literacy assessment tools for public physical education teachers in Chinese colleges and universities. The study measured the validity of the TCLQ-PPE questionnaire by collecting evidence of the validity of this questionnaire.

Methods: An initial pool of items was obtained from existing research tools, literature, and expert opinion.

Does Involution Cause Anxiety? An Empirical Study from Chinese Universities.

The debate over whether involution causes anxiety has persisted because no studies have attempted to quantify introversion and study its relationship to anxiety. This study quantified involution and explored its relationship with anxiety, provided evidence about whether involution was related to anxiety, and created a foundation for other scholars to carry out research on involution. Interviews and questionnaires were conducted to investigate the characteristics of 535 Chinese college students' involution behavior and its relationship with anxiety.

The Difference in Learning Activities of Postgraduate Students of Different Qualification Types Under the COVID-19 Pandemic: A Multi-Group Latent Class Analysis.

Introduction: There are two types of master's qualifications in China. One is the academic qualification that pays more attention to academic research, aiming to cultivate research-oriented talents; while the other is the application-oriented qualification that focuses more on practical ability, aiming to cultivate applied-oriented talents. The purpose of this study is to explore the impact of the COVID-19 on the learning activities of postgraduate students, as well as the differences in the extent to which the learning activities of postgraduate students of different qualification types are affected and their mental health status.

Fibrillary Glomerulonephritis and Monoclonal Gammopathy: Potential Diagnostic Challenges.

Fibrillary glomerulonephritis (FGN) is a rare glomerular disease featured by the randomly arranged 12- to 24-nm fibrils under electron microscopy (EM). Up to 10% of FGN patients have monoclonal gammopathy. However, distinguishing between FGN as monoclonal gammopathy of renal significance (MGRS) and FGN from other causes with incidental monoclonal gammopathy of undetermined significance (MGUS) can be challenging, as the current way of demonstrating monoclonality is flawed due to (1) the suboptimal sensitivity of kappa staining by immunofluorescence in frozen tissue (IF-F) as compared to pronase-digested paraffin sections (IF-P), causing incorrect labeling of light chain restriction; (2) the unavailability of immunoglobulin G (IgG) subtyping in some centers; and (3) the unavailability of tests demonstrating the monoclonality of highly variable VH or VL domains in immunoglobulin structures in clinical use.

Elevated Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Predict Drug-Induced Acute Kidney Injury.

Background: Urinary tissue inhibitor of metalloproteinase-2 (TIMP2) and insulin-like growth factor binding protein-7 (IGFBP7) predict severe acute kidney injury (AKI) in critical illness. Earlier but subtle elevation of either biomarker from nephrotoxicity may predict drug-induced AKI.

Methods: A prospective study involving serial urine collection in patients treated with vancomycin, aminoglycosides, amphotericin, foscarnet, or calcineurin inhibitors was performed.

LncRNA FGD5-AS1 enhances the proliferation and stemness of hepatocellular carcinoma cells through targeting miR-223 and regulating the expression of ECT2 and FAT1.

Aim: Hepatocellular carcinoma (HCC) is common and causes many deaths worldwide. The aim of this study is to explore the mechanism by which long non-coding RNA FGD5-AS1 regulates HCC cell proliferation and stemness.

Methods: Tumor and normal adjacent tissues were harvested from HCC patients.

How Course Support and Academic Support Impact on Chinese Graduate Students during the COVID-19: The Multiple Mediating Roles of Thesis Writing and Anxiety.

Because of the impact of the COVID-19 pandemic, the learning style of graduate students has changed considerably, making them more susceptible to psychological problems. This study aimed to explore the mediating roles of thesis writing and anxiety between course support (including course-arrangement, course-assessment, and course-learning), academic support (including academic exchange with colleges, tutors and schoolmates) and depression. There were 3137 graduate students investigated by self-developed Graduate Students' Academic Affected Questionnaire, Self-Rating Anxiety Scale and Self-Rating Depression Scale.

Impact of Academic Support on Anxiety and Depression of Chinese Graduate Students During the COVID-19 Pandemic: Mediating Role of Academic Performance.

Introduction: The COVID-19 pandemic broke out and has spread globally since 2019. It became a public health concern. This pandemic has brought tremendous changes in students' lives and modes of learning.

Chlorhexidine - a commonly used but often neglected culprit of dialysis associated anaphylactic reactions (case report).

Background: Hemodialysis-associated anaphylactic reactions are rare and frequently complex in nature due to the sheer number of possible culprit agents. Unfortunately, dialysis is often unavoidable or strictly essential for life-saving solute clearance or fluid removal in patients with end stage kidney failure and those with severe acute kidney injury. It is of utmost importance that the culprit agent is identified and avoided to allow continuation of dialysis treatment as needed.

Phylogeographic Investigation of an Endangered Longhorn Beetle, (Coleoptera: Cerambycidae), in Northeast Asia: Implications for Future Restoration in Korea.

The longhorn beetle, () Semenov, is the only remnant species found in the Palearctic region, while all other species are distributed mainly in Central America and partly in South America. This species has been placed in the first category (as 'critically endangered') of the Red Data Book in Russia and designated as one of the top-priority target species among all endangered invertebrate species for restoration in South Korea since 2006. Although its restricted distribution in Northeast Asia with a high conservational value has been highlighted, genetic features of from different geographic regions remain unexplored.

Serial Quantification of Urinary Protein Biomarkers to Predict Drug-induced Acute Kidney Injury.

Background: Drug-induced Acute Kidney Injury (AKI) develops in 10-15% of patients who receive nephrotoxic medications. Urinary biomarkers of renal tubular dysfunction may detect nephrotoxicity early and predict AKI.

Methods: We prospectively studied patients who received aminoglycosides, vancomycin, amphotericin, or calcineurin inhibitors, and collected their serial urine while on therapy.

Isolation and Characterization of subsp. BCBL-583 for Probiotic Applications in Fermented Foods.

Recent human gut microbiome studies have supported that the genus is one of the most beneficial bacteria for human intestinal health. To develop a new probiotic strain for functional food applications, fourteen fecal samples were collected from healthy Koreans and the strain BCBL-583 was newly selected and isolated from a 25-year-old Korean woman's fecal sample using the selective medium for . Subsequent fructose-6-phosphate phosphoketolase (F6PPK) test and 16S rRNA gene sequencing analysis of the strain BCBL-583 confirmed that it belongs to subsp.

Morphological anomalies of endangered Korean relict long-horned beetle (Cerambycidae, Coleoptera) during ontogenesis and possible causes of their occurrence.

This paper describes for the first time cases of exogenous morphological anomalies that occur during rearing of Semenov, 1899 in a laboratory setting. The highest frequency of the anomalies has been observed during pupation. It can be assumed that in beetles of this group, at final stages of ontogenesis, some abiotic factors such as humidity and temperature play an important role.

An integrative taxonomy on the locally endangered species of the Korean Scarabaeus (Coleoptera, Scarabaeidae).

The ball-rolling dung beetles of the genus Scarabaeus are very ecologically important for the recycling of feces of large herbivores and the related nature management. There has been a significant decline, however, in the numbers of many species at the population and individual levels. S.