is regulated by miR-642a-5p and promotes pancreatic cancer progression through the Wnt/β-catenin pathway.

Pancreatic cancer (PC) has a really poor prognosis, and we urgently need to delve deeper into its molecular mechanisms. In this study, we found that KRT19 expression was significantly increased in PC tissues and cell lines and it was linked to unfavorable outcomes for patients. Overexpression of KRT19 boosted the proliferation, migration, and invasion of PC cells.

Visualization of phenanthrene effect on biochar colloids transport in porous media.

Biochar colloids (BCs) can be used as adsorbent materials for remediation of phenanthrene due to their high specific surface area and other characteristics. Understanding the effects of phenanthrene on the transport of BCs contributes to facilitate the removal of phenanthrene in soil and water habitats. In this work, the influence of phenanthrene on the transport of BCs under different environmental factors (pH, ionic strength (IS), media size) in a one-dimensional sand column was firstly explored together with a real-time visualization system to explore the transport mechanism of BCs in two-dimensional sand tank.

Characterization of -deletion mutant Δ from and the evaluation as a live attenuated vaccine.

is the common pathogen affecting various species of marine organisms. It has been demonstrated that is a necessary virulence factor to adhere and infect their hosts for pathogenic bacteria. Frequent disease outbreaks in aquaculture have highlighted the necessity of developing effective vaccines.

Immune-enhancing effects of Astragalus polysaccharides and Ganoderma lucidum polysaccharides on Vibrio harveyi flgJ DNA vaccine in grouper.

Astragalus polysaccharides (APS) and Ganoderma lucidum polysaccharides (GLP) have been shown to possess strong immunoregulatory properties in aquatic animals. In this study, the fragment containing Vibrio harveyi flgJ gene was ligated into pcDNA3.1(+) vector and pcDNA3.

Construction of a phosphodiesterase mutant and evaluation of its potential as an effective live attenuated vaccine in pearl gentian grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatus).

Vibrio alginolyticus is a dominant pathogen that causes vibriosis of fish and shellfish. VAGM003125 is a specific phosphodiesterase bearing HD-GYP domain, which extensively regulates multicellular behavior and physiological processes in bacteria. In this study, an in-frame deleted ΔVAGM003125 mutant was constructed and changes of ΔVAGM003125 mutant in physiology and pathogenicity were examined.

Application of machine learning in predicting the adsorption capacity of organic compounds onto biochar and resin.

Detailed prediction of the adsorption amounts of organic pollutants in water is essential to the clean development and management of water resources. In this study, Kriging and polyparameter linear free energy relationship model are coupled to predict adsorption capacity of organic pollutants by biochar and resin. It's based on 1750 adsorption experimental data sets which contains 73 organic compounds on 50 biochars and 30 polymer resins.

Drop tower tests of Taiji-1 inertial sensor substitute.

Taiji-1, which is the first technical verification satellite of China's Space Gravitational Wave Detection Program, was successfully launched on August 31, 2019. The mission aimed to investigate the key technologies used in space gravitational wave detection. The inertial sensor, which was one of the main payloads, measured the residual acceleration of the satellite, and verified the drag-free control technology.

Application of kernel extreme learning machine and Kriging model in prediction of heavy metals removal by biochar.

Kernel extreme learning machine (KELM) and Kriging models are proposed to predict biochar adsorption efficiency of heavy metals. Both six popular ions (Pb, Cd, Zn, Cu, Ni, As) and single ion are considered to test the accuracy of KELM and Kriging models. Two ways (data selection and fix output value) are attempted to improve the model fitting accuracy and the best R can reach 0.

Complete mitochondrial genome of broadbanded cardinalfish () and phylogenetic analysis.

In this study, the complete mitochondrial genome (mitogenome) of was first determined and its phylogenetic position was investigated. The mitogenome was 16568 bp long and showed a typical teleost orders, containing 13 protein-coding genes (PCGs), 2 ribosome RNA genes (rRNAs), 22 transfer RNA genes (tRNAs), and a D-loop region. The overall nucleotide composition included A, 25.

Both Gfrα1a and Gfrα1b Are Involved in the Self-renewal and Maintenance of Spermatogonial Stem Cells in Medaka.

Glial cell-derived neurotrophic factor family receptor alpha-1 (GFRα1) plays a crucial role in the self-renewal and maintenance of spermatogonial stem cells (SSCs) from mammals. However, to date, our knowledge about its role in fish SSCs is limited. In the present study, the medaka (Oryzias latipes) gfrα1 duplicate genes, Olgfrα1a and Olgfrα1b, were cloned and characterized.

Weighted Large Margin Nearest Center Distance-Based Human Depth Recovery With Limited Bandwidth Consumption.

This paper proposes a weighted large margin nearest center (WLMNC) distance-based human depth recovery method for tele-immersive video interaction systems with limited bandwidth consumption. In the remote stage, the proposed method highly compresses the depth data of the remote human into skeletal block structures by learning the WLMNC distance, which is equivalent to downsampling the human depth map at $64{\times}$ the sampling rate. In the local stage, the method first recovers a rough human depth map based on a WLMNC distance augmented clustering approach and then obtains a fine depth map based on a rough depth-guided autoregressive model to preserve the depth discontinuities and suppress texture copy artifacts.

Medical Response to the Tianjin Explosions: Lessons Learned.

Background: On August 12, 2015, a hazardous chemical explosion occurred in the Tianjin Port of China. The explosions resulted in 165 deaths, 8 missing people, injuries to thousands of people. We present the responses of emergency medical services and hospitals to the explosions and summarize the lessons that can be learned.

Leukemia Inhibitory Factor Is Essential for the Self-Renewal of Embryonic Stem Cells from Nile Tilapia (Oreochromis niloticus) Through Stat3 Signaling.

To date, little is known about the mechanisms underlying the self-renewal of embryonic stem (ES) cells from fish species. In this study, we report that the leukemia inhibitory factor (LIF; named as OnLif) from a teleost fish, Nile tilapia (Oreochromis niloticus), is essential for the proliferation, survival, and pluripotency maintenance of Nile tilapia ES cells (TES1) by activating the signal transducer and activator of transcription 3 (Stat3). This protein has 221 amino acid residues with similar sequence features to mammalian LIF.

Promoter activity and regulation of the Pou5f1 homolog from a teleost, Nile tilapia.

Mammalian POU5F1 (also known as OCT4) is an essential transcription factor that induces and controls stemness in the inner cell mass and embryonic stem (ES) cells. Its expression results from intricate regulatory networks involving its 5' upstream DNA elements and numerous transcription factors. Pou5f3, the ortholog of POU5F1, has been identified in non-mammalians including fish.

[Research progress on the mechanisms and influence factors of nitrogen retention and transformation in riparian ecosystems.].

Riparian zone, the ecological transition buffer between terrestrial and aquatic ecosystems (rivers, lakes, reservoirs, wetlands, and other specific water bodies) with unique eco-hydrological and biogeochemical processes, is the last ecological barrier to prevent ammonium, nitrate and other non-point nitrogen pollutants from adjacent water bodies. Based on a summary of current progress of related studies, we found there were two major mechanisms underpinning the nitrogen retention/removal by the riparian ecosystems: 1) the relative locations of nitrogen in the soil-plant-atmosphere continuum system could be altered by riparian vegetation; 2) nitrogen could also be denitrified and then removed permanently by microorganisms in riparian soil. However, which process is more critical for the nitrogen removal remains elusive.

[Traffic injuries of pre-hospital treatment in the urban area of Beijing].

Objective: To evaluate the current condition of urban road traffic injuries (RTIs) according to Beijing Emergency Medical Center (BEMC) from Jan. 1, 2004 to Dec. 31, 2010, analyze the social characteristics and explore the possible methods for prevention and improvement.

Relationship between haze and acute cardiovascular, cerebrovascular, and respiratory diseases in Beijing.

Haze is an atmospheric phenomenon in which dry particulate pollutants obscure the sky. Haze has been associated with chronic diseases, but its relationship with acute diseases is less clear. We aimed to determine the association between haze and acute cardiovascular, cerebrovascular, and respiratory diseases, in order to determine the influence of haze on human health.

Muscle activity and co-contraction of musculoskeletal model during steering maneuver.

In this study a musculoskeletal model of driver steering maneuver was established. The model was driven by the steering angle and steering torque when performing typical steering test. The simulation was calculated using inverse dynamics.