Rh-Catalyzed Direct Heteroarylation of Unactivated C(sp)-H with -Heteroaryl Boronates.

Disclosed herein is a rhodium(III)-catalyzed direct heteroarylation reaction between unactivated aliphatic C(sp)-H bonds in 2-alkylpyridines and heteroaryl organoboron reagents. This catalytic protocol is compatible with various heterocyclic boronates containing - and -pyridine, pyrazoles, furan, and quinoline with strong coordination capability. The achievement of this methodology provides an efficient route to build new C(sp)-heteroaryl bonds.

Solitary bone plasmacytoma of spine with involvement of intervertebral disk: a case report and literature review.

Primary malignant bone tumors of the spine are exceedingly rare, with solitary bone plasmacytoma (SBP) representing approximately 30% of all cases. Radiological assessments are crucial for localizing SBP and for ruling out a diagnosis of multiple myeloma (MM). Imaging features resembling a "mini-brain" appear to be distinctive for SBP.

Discovery of the novel HLA-A*11:452N allele by next-generation sequencing in a Chinese individual.

HLA-A*11:452N differs from A*11:01:01:01 by a single nucleotide exchange in exon 1.

Genomic sequence of the novel HLA-A*26:206:02N allele, identified in a patient with hepatitis B infection.

HLA-A*26:206:02N differs from A*26:01:01:01 by a single nucleotide exchange in exon 3.

Rh-promoted directed C-H N-heteroarylation of 2-pyridones.

A catalytic protocol for the Cp*Rh-promoted C6-selective N-heteroarylation of 2-pyridones with N-heterocyclic boronates has been successfully developed utilizing a removable pyridine auxiliary. This system features high efficiency with mild conditions and also tolerates - and -substituted pyridines, pyrazoles, pyrimidine, non-substituted quinolines, thiophene and furan well. The easy synthetic approach could potentially be applied to construct heterocyclic drug molecules bearing 2-pyridone-heteroaryl motifs.

A "Pre-Division Metal Clusters" Strategy to Mediate Efficient Dual-Active Sites ORR Catalyst for Ultralong Rechargeable Zn-Air Battery.

To conquer the bottleneck of sluggish kinetics in cathodic oxygen reduction reaction (ORR) of metal-air batteries, catalysts with dual-active centers have stood out. Here, a "pre-division metal clusters" strategy is firstly conceived to fabricate a N,S-dual doped honeycomb-like carbon matrix inlaid with CoN sites and wrapped Co P nanoclusters as dual-active centers (Co P/CoN @NSC-500). A crystalline {Co } coordination cluster divided by periphery second organic layers is well-designed to realize delocalized dispersion before calcination.

Pt Nanoparticles Confined in a 3D Porous FeNC Matrix as Efficient Catalysts for Rechargeable Li-CO/O Batteries.

The cathodic product LiCO, due to its high decomposition potential, has hindered the practical application of rechargeable Li-CO/O batteries. To overcome this bottleneck, a Pt/FeNC cathodic catalyst is fabricated by dispersing Pt nanoparticles (NPs) with a uniform size of 2.4 nm and 8.

One-Pot Construction of Heteroarylation/Esterification Products of Acrylic Acids via Iridium(III)-Catalyzed C-H Activation.

A carboxylate-assisted iridium(III)-catalyzed regioselective C(sp)-H heteroarylation/esterification reaction of acrylic acid is disclosed herein for the first time. This catalytic protocol tolerates various α-substituted, β-substituted, and α, β-disubstituted acrylic acids as well as heteroaromatic boronates well. The resulting 3,4-dihydro-2-pyran-6-carboxylic acid derivative highlighted the AIE-active luminophore with multiple emission signal properties and a high quantum yield of 28%, exhibiting the potential application of this methodology for the synthesis of nitrogen-containing organic functional materials.

Rh-Catalyzed C-H -Heteroarylation and Esterification Cascade of Carboxylic Acid with Organoboron Reagents and 1,2-Dichloroethane in One-Pot Synthesis.

A Rh-catalyzed C(sp)-H -heteroarylation and esterification cascade of aryl carboxylic acids with -heteroaromatic boronates and 1,2-dichloroethane in a one-pot synthesis has been disclosed. The strong coordinating ability of - and -substituted pyridine boronates and pyrazoles as well as unsubstituted pyrimidine allows them to serve as the coupling partners. This protocol allows late-stage modification of the key precursor of roflumilast and compounds of pharmaceutical interest, which highlights the potential application of this synthetic method.

[Molecular polymorphism Analysis on CD36 Deficiency among Platelet Blood Donors in Shenzhen].

Objective: To analyze the molecular polymorphisms of CD36 among 58 blood donors with CD36 deficiency and compare with CD36 positive controls.

Methods: A total of 58 donors with CD36 deficiency during a screening conducted in the laboratory from September 2019 to December 2020 were enrolled as the test group, including 39 males and 19 females, while 120 platelet donors with CD36 positive were randomly selected as the controls, including 76 males and 44 females. All of the subjects were Han nationality.

Evidence-based intervention on postoperative fear, compliance, and self-efficacy in elderly patients with hip fracture.

Background: Elderly patients tend to have poor self-efficacy and poor confidence in postoperative rehabilitation for hip fractures, and are prone to negative emotions, which affect treatment compliance.

Aim: To evaluate the effects of evidence-based intervention on postoperative fear, compliance, and self-efficacy in elderly patients with hip fractures.

Methods: A total of 120 patients with hip fracture surgically treated from June 2018 to June 2020 at the orthopedic department of our hospital were selected and divided into intervention and routine groups ( = 60 each) according to different nursing methods.

Interpenetrated N-rich MOF derived vesicular N-doped carbon for high performance lithium ion battery.

High-performance lithium ion batteries (LIBs) juggling high reversible capacity, excellent rate capability and ultralong cycle stability are urgently needed for all electronic devices. Here we report employing a vesicle-like porous N-doped carbon material (abbr. N/C-900) as a highly active anode for LIBs to balance high capacity, high rate and long life.

Asymptomatic chronic suppurative cholecystitis and peritonitis mimicking metastasis by F-FDG PET/CT scan during sigmoid colon cancer surveillance.

The study describes an unusual case that a patient with previous history of adenocarcinoma of sigmoid colon who has developed chronic suppurative cholecystitis and peritonitis was misdiagnosed as metastasis. This case is presented to illustrate the importance of considering benign etiologies that may mimic metastatic disease when interpreting positron emmision tomography (PET)/CT scans.

Synthesis and Evaluation of Radioiodine-Labeled pH (Low) Insertion Peptide Variant 7-Like Peptide as a Noninvasive Tumor Microenvironment Imaging Agent in a Mouse MDA-MB-231 Triple-Negative Breast Cancer Model.

Purpose: The pH (low) insertion peptide (pHLIP) family can target the tumor microenvironment (TME). If pHLIP can be labeled with radioiodine, the imaging and treatment of tumors can be considered. However, tyrosine and tryptophan can bind with iodine in the insertion region of pHLIP, and radioiodine labeling may affect the formation of α-helix structures in acidic environments; therefore, it is necessary to adjust the structure of pHLIP.

The synthesis of aryl-heteroaryl derivatives the Rh-catalyzed heteroarylation of arenes and heteroaromatic boronates.

An efficient Rh-catalyzed strategy for constructing aryl-heteroaryl derivatives with removable ketoxime ether auxiliaries direct C-H heteroarylation based on arenes and heteroaromatic boronates has been disclosed. This protocol could tolerate various pyridine, pyrimidine, pyrazole, thiophene, and furan heteroaromatic boronates well, providing the desired products with high reactivities and excellent regioselectivity. The easy synthetic accessibility may offer potential for application in the synthesis of heterocyclic drug molecules containing aryl-heteroaryl motifs.

Rh-Catalyzed Direct Heteroarylation of C(sp)-H and C(sp)-H Bonds in Heterocycles with -Heteroaromatic Boronates.

Herein, we disclose a Rh-catalyzed heteroarylation of C(sp)-H and C(sp)-H bonds in heterocycles with organoboron reagents. This protocol displays high efficiency and excellent functional group tolerance. A range of heterocyclic boronates with strong coordinating atoms, including pyridine, pyrimidine, pyrazole, thiophene, and furan derivatives, can be extensively served as the coupling reagents.

Identification of the novel HLA-DRB3*02:02:19 allele.

The HLA-DRB3*02:02:19 allele differs from DRB3*02:02:01:02 by a single nucleotide change in exon 2.

A Co-MOF-derived CoS@NS-C electrocatalyst for efficient hydrogen evolution reaction.

The exploitation of efficient hydrogen evolution reaction (HER) electrocatalysts has become increasingly urgent and imperative; however, it is also challenging for high-performance sustainable clean energy applications. Herein, novel CoS nanoparticles embedded in a porous N,S-dual doped carbon composite (abbr. CoS@NS-C-900) were fabricated by the pyrolysis of a single crystal Co-MOF assisted with thiourea.

Rh-Catalyzed C-H (Het)arylation/Vinylation of -2,6-Difluoroaryl Acrylamides.

Rh-catalyzed sp C-H cross-coupling of acrylamides with organoboron reactants has been accomplished using a commercially available -2,6-difluoroaryl acrylamide auxiliary. A broad range of aryl and vinyl boronates as well as a variety of heterocyclic boronates with strong coordinating ability can serve as the coupling partners. This transformation proceeds under moderate reaction conditions with excellent functional group tolerance and high regioselectivity.

Nanocage-Based N-Rich Metal-Organic Framework for Luminescence Sensing toward Fe and Cu Ions.

Luminescent metal-organic frameworks (LMOFs) as sensors showing highly efficient detection toward toxic heavy-metal ions are in high demand for human health and environmental protection. A novel nanocage-based N-rich LMOF () has been constructed and characterized. It is a 2-fold interpenetrating structure built from N-rich {Zn(dttz)} nanocages extended by N-donor ligand Hdpa [Hdttz = 4,5-di(1-tetrazol-5-yl)-2-1,2,3-triazole; Hdpa = 4,4'-dipyridylamine].

Fe-MOF-Derived Efficient ORR/OER Bifunctional Electrocatalyst for Rechargeable Zinc-Air Batteries.

The construction of an efficient oxygen reduction reaction and oxygen evolution reaction (ORR/OER) bifunctional electrocatalyst is of great significance but still remains a giant challenge for high-performance metal-air batteries. In this study, uniform FeS/FeC nanoparticles embedded in a porous N,S-dual doped carbon honeycomb-like composite ( FeS/FeC@NS-C-900) have been conveniently fabricated by pyrolysis of a single-crystal , which has a low potential gap Δ of ca. 0.

Investigating the effect of lanthanide radius and diamagnetic linkers on the framework of metallacrown complexes.

By changing the stoichiometric ratios, the one-pot reaction of the glycinehydroxamic acid (H2glyha) ligand with copper(ii) and lanthanide(iii) salts in the presence of diamagnetic [Na2{Fe(CN)5(NO)}] led to two series of isostructural complexes, which can be designated as heterotrimetallic dimeric clusters [{LnCu5(glyha)5}{Fe(CN)5(NO)}(H2O)4]2·xNO3·yH2O (x = 2, y = 11 for La (1), x = 2, y = 11 for Pr (2), and x = 2, y = 11 for Nd (3)) and heterotetrametallic coordination polymers [Na{LnCu5(glyha)5}{Fe(CN)5(NO)}2(H2O)x·yH2O]n (x = 6, y = 4 for Sm (4), x = 6, y = 0 for Gd (5), x = 6, y = 4 for Tb (6), x = 5, y = 5 Dy (7), and x = 6, y = 4 for Ho (8)). Each molecular structure contains LnIII[15-metallacrown-5] nodes and diamagnetic [Fe(CN)5(NO)]2- linkers. The resulting products demonstrate diversified structural frameworks due to the radius effect of LnIII ions and different bridging fashions of diamagnetic [Fe(CN)5(NO)]2- linkers.

Two microporous Co-MOFs with dual active sites for highly selective adsorption of CO/CH and CO/N.

Simultaneously involving abundant [NH2(CH3)2]+ cations and uncoordinated carboxylate oxygen atoms as dual active sites, two microporous CoII-MOFs (LCU-105 and LCU-106, LCU = Liaocheng University) both exhibit highly selective adsorption of CO2/CH4 and CO2/N2. GCMC theoretical simulations provide good verification of the experimental results.

Room temperature synthesis of CdS/SrTiO nanodots-on-nanocubes for efficient photocatalytic H evolution from water.

Spontaneous solar-driven water splitting to generate H with no pollution discharge is an ideal H generation approach. However, its efficiency remains far from real application owing to the poor light-harvesting and ultrafast charge recombination of photocatalysts. To address these issues, herein, we employed a novel but simple chemical bath deposition (CBD) method to construct CdS/SrTiO nanodots-on-nanocubes at room temperature (ca.