Duodenogastric reflux in patients with gastric ulcer disease.

We studied reflux of duodenal contents into the stomach in patients with gastric ulcers, patients with duodenal ulcers, and normal subjects. Duodenogastric reflux was assessed in the fasting state and after cholecystokinin octapeptide administration (0.02 micrograms/kg intravenously).

Transient pure red-cell aplasia: cell-mediated suppression of erythropoiesis associated with hepatitis.

Transient pure red-cell aplasia is a rare complication of persistent acute hepatitis. We have investigated possible mechanisms for marrow suppression in one such patient who developed erythroid aplasia in the course of transfusion-related hepatitis. The patient's lymphocytes, obtained during the acute illness, markedly inhibited erythroid colony formation by donor marrow.

Factors influencing small bowel changes in dermatitis herpetiformis.

Factors influencing small bowel morphology in dermatitis herpetiformis (DH) were investigated by comparing patients with DH and normal small bowel biopsies to patients with DH and abnormal small bowel biopsies. The mean age of 18 patients with morphological changes in small bowel (38 years) was significantly lower (P less than 0-001) than the mean age of nine patients with normal bowel mucosa (60 years). HLA typing confirmed the high frequency of HLA-B8 in DH (64%) but HLA-B8 was unrelated to the presence or severity of small bowel lesions.