Oxidation of alcohol in free-moving mice from high and low preference strains.

Free-moving mice from the high-alcohol preference C57BL/6J strain and low-preference DBA/2J strain were slowly fed [2-14C]ethanol intragastrically until anesthesia was achieved. Behavior was monitored in a Plexiglas metabolic chamber while 14CO2 was simultaneously trapped to determine the rate of ethanol metabolism. Average time to the loss of the righting reflex in the DBA/2J was 21.

Tellurium-induced myelinopathy in adult rats.

Tellurium is known to induce a neuropathy in young rats but not in adult rats. In the present study adult rats were fed a diet containing 1.25% tellurium every day for 30 days.

Proliferation of Schwann cells in tellurium-induced demyelination in young rats. A radioautographic and teased nerve fiber study.

This is a study of DNA synthesis of Schwann cells during the demyelination and the remyelination of peripheral nerves secondary to the intoxication of young rats with tellurium (Te). 3H-thymidine uptake of Schwann cells begins on day 4, reaches a zenith on day 7, and ends before day 20 on the Te diet despite continuation of the diet. The chronology of pathologic events is that myelin breakdown leading to segmental demyelination occurs first, followed within 24--48 h by the appearance of paralysis and by the beginning of DNA synthesis by the Schwann cells.

Electron microprobe ultrastructural localization of aluminum in rat brain.

Adult white rats were injected daily for 1 month with aluminum chloride and killed. Aluminum was identified, quantitated, and localized in the brains of these rats. The only detectable anomalies were crystals of aluminum and phosphorus in lysosomes and lipofuscin granules in the cytoplasm of neurons.

50ppm MnBK subclinical neuropathy in rats.

40 rats were subjected daily for 6 months to an atmosphere containing 50ppm MnBK. 32 of the rats presented with demyelination of the sciatic nerve and 2 of these with axonal hypertrophy.

Tellurium-induced neuropathy: correlative physiological, morphological and electron microprobe studies.

Elemental tellurium (TE) was included in the normal diet of 15-day-old rats and every day thereafter for 35 days. Within 24 hours a segmental demyelination was seen in the sciatic nerve. On the 2nd day, Te was localized in the cytoplasm of the Schwann cells.

Myokymia and impaired muscular relaxation with continuous motor unit activity.

We have studied two cases of the syndrome of myokymia and impaired muscular relaxation with continuous motor unit activity. Both patients complained of muscle twitching, weakness, stiffness, and hyperhydrosis during their illness. Myokymia was present over the entire body in both.

Electron microprobe study of calcifications in human brain tumors.

Preliminary electron microprobe studies of a small number of meningiomas, oligodendrogliomas, glioblastoma multiformae, craniopharyngiomas, and metastatic epithelioma of the breast suggest that the elemental composition of the deposits associated with these tumors is characteristic for each type of tumor.

Inter omental-cerebral vascularization induced by omental graft to the rat brain.

The omentum of 13 rats were removed from the abdomen and placed directly on the brain. 5-14 days later the omentum and the underlying brain were joined by numerous vascular anastomoses in 9 rats. The purpose of this work was to study the use of omentum to establish extracranial vascularization of the brain.

An index of hospital performance.

The purpose of this paper is to describe a simple index for computing relative hospital performance. An analysis of 33 short-stay general hospitals in New South Wales was used to develop the index. The index is based on patterns of admissions for each hospital, adjusting the hospital's crude death rate for the age distribution of patients treated and variations in the severity of their diagnoses.

Prevention of cerebral infarction in the monkey by omental transposition to the brain.

The intact omentum of 13 monkeys was lengthened, placed subcutaneously, and laid on the left cerebral hemisphere prior to occluding the left middle cerebral artery. Two of these 13 monkeys developed left cerebral infarct and a right hemiparesis. Nine other monkeys had their left middle cerebral artery occluded without omental protection.

The relationship between Parkinson syndrome and vascular siderosis: an electron microprobe study.

Vascular siderosis (VS) refers to the presence of mineralized small and medium-sized arteries in the globus pallidus, usually regarded as reflecting an aging process. The electron probe analysis of deposits in vascular siderosis in 10 patients dying of parkinsonism and in 8 other patients without parkinsonism is reported here. The microprobes identified a total of 11 elements in the VS in these 18 patients.

Presence of zinc, aluminum, magnesium in striopalledodentate (SPD) calcifications (Fahr's disease): electron probe study.

SPD calcifications from four cases of Fahr's disease were studied with an electron microprobe of Castaing, and found to contain different elements, among them Zn, Al, Mg. The presence of the elements is underlined not because of presumption as to their importance on the pathogenesis of this disease, but because of their rare identification in cerebral calcifications. A1 and Mg have been localized previously in cerebral calcification, but this is the first report of morphological localization of a high concentration of zinc in the brain.

Microprobe scanning of normal and pathological human peripheral nerve.

The localization of calcium (Ca) and phosphorus (P) by scanning with the electron microprobe of Casting, provides a morphological outline of the normal nerve which can be used qualitatively and quantitatively for comparison with abnormal nerves. The normal saphenous nerves of eight cadavers and the abnormal saphenous nerves of two cases of diabetic neuropathy, were scanned and the results compared.