Prediction of allograft function in pre-transplant kidneys using sound touch elastography (STE): an ex vivo study.

Background: The purpose of the study was to evaluate renal quality and predict posttransplant graft function using ex vivo sound touch elastography (STE).

Methods: In this prospective study, 106 donor kidneys underwent ex vivo STE examination and biopsy from March 2022 to August 2023. The mean stiffness of the superficial cortex (STE), deep cortex (STE), and medulla (STE) was obtained and synthesized into one index (STE) through the factor analysis method.

Global bibliometric mapping of the research trends in artificial intelligence-based digital pathology for lung cancer over the past two decades.

Background And Objective: The rapid development of computer technology has led to a revolutionary transformation in artificial intelligence (AI)-assisted healthcare. The integration of whole-slide imaging technology with AI algorithms has facilitated the development of digital pathology for lung cancer (LC). However, there is a lack of comprehensive scientometric analysis in this field.

CuFeO/lignin-based carbon composited photothermal and photodynamic agents for synergetic antibacterial therapy.

Bacterial infection has become the second leading cause of death in the world. Exploring a new highly antibacterial catalyst to replace traditional antibacterial agent is crucial for the society development of human beings. In this study, CuFeO/Lg-based carbon composited catalysts were rationally constructed by facile hydrothermal method.

Sarcanoids A and B, two new lindenane-type sesquiterpenoid dimers from the aerial parts of .

Sarcanoids A and B ( and ), two new lindenane-type sesquiterpenoid dimers with a γ-hydroxysenecioate moiety at C-15', were isolated from the ethyl acetate extract of . The structures were elucidated by extensive analysis of spectroscopic data, and their absolute configurations were determined by single-crystal X-ray crystallography. Compounds and showed moderate inhibitory activities on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.

3D printing of fish-scale derived hydroxyapatite/chitosan/PCL scaffold for bone tissue engineering.

In the field of bone tissue repair, the treatment of bone defects has always posed a significant challenge. In recent years, the advancement of bone tissue engineering and regenerative medicine has sparked great interest in the development of innovative bone grafting materials. In this study, a novel hydroxyapatite (HA) material was successfully prepared and comprehensively characterized.

Fabricating active Egg Albumin/Sodium Alginate/Sodium Lignosulfonate Nanoparticles film with significantly improved multifunctional characteristics for food packing.

In food packaging, sodium lignosulfonate nanoparticles (SLS NPs) showed significant antibacterial properties, antioxidant and UV barrier activities. Herein, the SLS NPs were synthesized via a sustainable green method and were added into egg albumin/sodium alginate mixture (EA/SA) to fabricate a safe, edible EA/SA/SNPs food packaging. A composite film EA/SA/SNP was examined microstructurally and physicochemically.

Tracheal regeneration and mesenchymal stem cell augmenting potential of natural polyphenol-loaded gelatinmethacryloyl bioadhesive.

Hydrogels incorporating natural biopolymer and adhesive substances have extensively been used to develop bioactive drugs and to design cells encapsulating sturdy structure for biomedical applications. However, the conjugation of the adhesive in most hydrogels is insufficient to maintain long-lasting biocompatibility inadequate to accelerate internal organ tissue repair in the essential native cellular microenvironment. The current work elaborates the synthesis of charged choline-catechol ionic liquid (BIL) adhesive and a hydrogel with an electronegative atom rich polyphenol (PU)-laden gelatinmethacryloyl (GelMA) to improve the structural bioactivities for in vivo tracheal repair by inducing swift crosslinking along with durable mechanical and tissue adhesive properties.

Polysaccharide- and protein-based edible films combined with microwave technology for meat preservation.

To reduce food-borne bacterial infection caused by food spoilage, developing highly efficient food packing film is still an urgent need for food preservation. Herein, microwave-assisted antibacterial nanocomposite films CaO@PVP/EA/CMC-Na (CP/EC) were synthesized using waste eggshell as precursor, egg albumen (EA) and sodium carboxymethylcellulose (CMCNa) as matrix by casting method. The size of CaO@PVP (CP) nanoparticles with monodisperse spherical structures was 100-240 nm.

Emerging ferroelectric materials ScAlN: applications and prospects in memristors.

The research found that after doping with rare earth elements, a large number of electrons and holes will be produced on the surface of AlN, which makes the material have the characteristics of spontaneous polarization. A new type of ferroelectric material has made a new breakthrough in the application of nitride-materials in the field of integrated devices. In this paper, the application prospects and development trends of ferroelectric material ScAlN in memristors are reviewed.

Nursing students'experience of flipped classroom combined with problem-based learning in a paediatric nursing course: a qualitative study.

Background: Problem-based learning (PBL) is a student-centred approach that triggers learning by presenting problems cenarios early in the learning process.Flipped classrooms have been used in various disciplines using various models.Pre-class e- learning in aflipped classrooms can enrich knowledge acquisition in PBL teaching.

Visual and auditory attention defects in children with intermittent exotropia.

Background: Previous studies have shown that children with intermittent exotropia (IXT) have a higher rate of psychiatric abnormalities as they grow up, such as attention deficit. This study explored visual and hearing attention among children with IXT, and evaluated its association with clinical characteristics and cognitive development.

Methods: Forty-nine children with a diagnosis of IXT and 29 children with traditional development were recruited.

Self-Assembled and Multilayer-Overlapped ESM-PDA@rGO Nanofilm-Based Flexible Wearable Sensor for Real-Time Body Temperature Monitoring.

There is an urgent need for wearable sensors that continuously monitor human physiological conditions in real time. Herein, an ESM-PDA@rGO-based flexible wearable temperature sensor was successfully constructed by integrating an eggshell membrane (ESM) with reduced graphene oxide (rGO) through dopamine (DA) polymerization. Depending on the "bridge effect" of diversified polydopamine (PDA) chains, on the one hand, a staggered arrangement of PDA-rGO frameworks and a lot of conductive pathways were produced and acted as an active layer.

C-doped ZnO nanocomposites molecularly imprinted photoelectrochemical sensor for ultrasensitive and selective detection of oxytetracycline in milk.

Antibiotic monitoring remains vital to ensure human health and safety in the environment and foods. As the most popular detection method, photoelectrochemical (PEC) sensor can achieve rapid and accurate detection of antibiotics with the advantages of high sensitivity, easy-to-preparation process, as well as high selectivity. Herein, an extremely-efficient visible-light responsible ZnO/C nanocomposite was prepared and combined with acetylene black (as an enhanced conductive matrix), and the electron migration efficiency was greatly accelerated.

Hydrophilic ZnO/C nanocomposites with superior adsorption, photocatalytic, and photo-enhanced antibacterial properties for synergistic water purification.

Owing to the numerous potential applications of ZnO nanomaterials, the development of ZnO-based nanocomposites has become of great scientific interest in various fields. In this paper, we are reporting the fabrication of a series of ZnO/C nanocomposites through a simple "one-pot" calcination method under three different temperatures, 500 ℃, 600 ℃, and 700 ℃, with samples labeled as ZnO/C-500, -600, and -700, respectively. All samples exhibited adsorption capabilities and photon-activated catalytic and antibacterial properties, with the ZnO/C-700 sample showing superior performance among the three.

Rapid and sensitive dilute-and-shoot analysis using LC-MS-MS for identification of multi-class psychoactive substances in human urine.

The emergence of new psychoactive substances currently exceeding a thousand is rapidly changing substance prevalence patterns and straining the methods used for detection, most of which are suitable only for a single class of substances. This study presents a rapid and facile dilute-and-shoot system operated in conjunction with an optimized liquid chromatographic separation system for the high-sensitivity detection of substances across a range of substance classes with 3 isotopes used only. The proposed method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) is able to identify 68 substance and their metabolites in urine samples as small as 50 μL.

Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia.

Mismatch repair (MMR) deficiency has been linked to thiopurine resistance and hypermutation in relapsed acute lymphoblastic leukemia (ALL). However, the repair mechanism of thiopurine-induced DNA damage in the absence of MMR remains unclear. Here, we provide evidence that DNA polymerase β (POLB) of base excision repair (BER) pathway plays a critical role in the survival and thiopurine resistance of MMR-deficient ALL cells.

The influence of substrates addition order on colorimetric assay based on MnO nanocubes: A novel turn-off HO assay strategy in water-soak foods.

Herein, novel MnO nanocubes were facilely synthesized by manipulating the dosage of KMnO and l-Dopa with the aid of ultrasound. The as-prepared MnO nanocubes exhibited interesting oxidation activity which was influenced by the addition order of substrates (HO and 3,3,5,5-tetramethylbenzidine (TMB)). After the mechanism study, we found that HO and TMB can be competitively oxidized by MnO nanocubes, which was different from the peroxidase- and oxidase-like activities.

Recent advances in luminescence and aptamer sensors based analytical determination, adsorptive removal, degradation of the tetracycline antibiotics, an overview and outlook.

Tetracycline antibiotics (TCs), one of the important antibiotic groups, have been widely used in human and veterinary medicines. Their residues in foodstuff, soil and sewage have caused serious threats to food safety, ecological environment and human health. Here, we reviewed the potential harms of TCs residues to foodstuff, environment and human beings, discussed the luminescence and aptamer sensors based analytical determination, adsorptive removal, and degradation strategies of TCs residues from a recent 5-year period.

A dual (mesoporous and macroporous) system loaded with cell-free fat extract to optimize bone regeneration microenvironment.

Injured bone regeneration requires a systemically and carefully orchestrated series of events involving inflammation, angiogenesis, and osteogenesis. Thus, we designed a multifunctional cell-supporting and drug-retarding dual-pore system: cell-free fat extract (Ceffe)-mesoporous silica nanoparticle (MSN)@poly(lactic--glycolic acid) (PLGA) (Ceffe-MSN@PLGA) to mimic the developmental spatial structure, the microenvironment of bone regeneration and integration during injured bone regeneration. In this system, a macroporous scaffold (pore size 200-250 μm) of PLGA is combined with mesoporous MSN (pore size 2-50 nm), aiming at realizing the slow release of Ceffe.

ZnO/C nanocomposite grafted molecularly imprinted polymers as photoelectrochemical sensing interface for ultrasensitive and selective detection of chloramphenicol.

Nanomaterials-based photoelectrochemical (PEC) detection is becoming a rapidly-developing analytical technique in chemical and biological assays due to its unique advantages of easy miniaturization, high sensitivity, and rapid turnaround time. Herein, a molecularly imprinted polymer-assisted PEC sensor based on ZnO/C nanocomposite was successfully fabricated for the highly sensitive and selective determination of chloramphenicol (CAP). Benefiting from the hydrophilic functional groups (-OH, -COOH) and large surface area of bio-templated ZnO/C nanocomposite, the tight grafting of MIP with excellent recognition ability on substrate is easier and more stable than traditional PEC sensor, thus significantly increasing the performance.

[Analgesic effect and mechanism of electroacupuncture on SNI rats based on microglia-BDNF-neuron signal].

Objective: To observe the effect of electroacupuncture (EA) at "Huantiao" (GB 30) and "Weizhong" (BL 40) on the activation of glial cells, the expression of brain-derived neurotrophic factor (BDNF), excitability and the number of dendritic spines of neurons in the spinal dorsal horn in rats with spared nerve injury (SNI) of sciatic nerve, and to explore the analgesic mechanism of EA on SNI.

Methods: PartⅠ: Sixty SD rats were randomly divided into a sham operation group, a model group, an EA group and a sham EA group, 15 rats in each group. Except the sham operation group, the SNI rat model was established in the remaining groups.

An ultrasensitive cathodic electrochemiluminescence immunoassay for thrombomodulin based on Ru(bpy) encapsulated by MIL-NH-101(Al) nanocomposites.

The rapid and reliable determination of thrombomodulin (TM) is of great significance for the diagnosis of disseminated intravascular coagulation, thrombosis and others. This work exhibits an electrochemiluminescent (ECL) sensor, which was prepared using Ru(bpy) encapsulated by MIL-NH-101(Al) nanocomposites for the sensitive detection of the new-thrombus marker thrombomodulin (TM) for the first time. Specifically, on one hand, with the advantages of high specific surface area, large hollow porous structure and favorable biocompatibility, MIL-NH-101(Al) could load a large amount of luminescent Ru(bpy) and thereby greatly enhance the ECL signal of the immunosensor.

A fish-scale derived multifunctional nanofiber membrane for infected wound healing.

The rapid development of modern medicine has put forward new requirements for wound infection healing methods in clinical treatment. Despite the great achievements made in the research and development of various types of dressings in recent years, yet there is still a challenge of multifunctional dressings for effective wound treatment. Herein, a multifunctional nanofibrous membrane was prepared by encapsulating NIR-adsorbed CuS (FSC/CuS) nanoparticles, polyvinylpyrrolidone (PVP) and polyvinyl butyral (PVB) with electrospun fish scale collagen.

Designing waste Bioresource-derived value-added Nanohybrids for efficient photocatalysis water treatment.

Although photocatalysis with ultraviolet-visible (UV-vis) light has made considerable advances, it is limited by the low efficiency of UV-vis energy conversion. To overcome this problem, UV-vis light can be replaced with near-infrared (NIR) light. Herein, we coupled eggshell-derived CaCO with a NIR-absorbing CuSe semiconductor and fabricated an insulator-based heterojunction structure.