Minerva: a light-weight, narrative image browser for multiplexed tissue images.

Advances in highly multiplexed tissue imaging are transforming our understanding of human biology by enabling detection and localization of 10-100 proteins at subcellular resolution (Bodenmiller, 2016). Efforts are now underway to create public atlases of multiplexed images of normal and diseased tissues (Rozenblatt-Rosen et al., 2020).

Bioinformatics: how it is being used to identify bacterial vaccine candidates.

Genomic sequencing has provided a tremendous amount of information that can be useful in vaccine target identification. The sheer volume of information available necessitates the use of new research disciplines and techniques. Using bioinformatics, researchers sift through available data to identify appropriate candidates for biological analysis.

Increased synchronization of neuromagnetic responses during conscious perception.

In binocular rivalry, the observer views two incongruent images, one through each eye, but is conscious of only one image at a time. The image that is perceptually dominant alternates every few seconds. We used this phenomenon to investigate neural correlates of conscious perception.

Treatment of baseline drifts in fMRI time series analysis.

Purpose: Gradual drifting of baseline signal intensity is common in functional MRI (fMRI) time course data. Methods for dealing with this effect are studied.

Method: Simulations and fMRI data are used to study three statistical models that account for baseline drift.

Functional clustering: identifying strongly interactive brain regions in neuroimaging data.

Brain imaging data are generally used to determine which brain regions are most active in an experimental paradigm or in a group of subjects. Theoretical considerations suggest that it would also be of interest to know which set of brain regions are most interactive in a given task or group of subjects. A subset of regions that are much more strongly interactive among themselves than with the rest of the brain is called here a functional cluster.

Investigating neural correlates of conscious perception by frequency-tagged neuromagnetic responses.

In binocular rivalry, a subject views two incongruent stimuli through each eye but consciously perceives only one stimulus at a time, with a switch in perceptual dominance every few seconds. To investigate the neural correlates of perceptual dominance in humans, seven subjects were recorded with a 148-channel magnetoencephalography array while experiencing binocular rivalry. A red vertical grating flickering at one frequency was presented to one eye through a red filter and a blue horizontal grating flickering at a different frequency was presented to the other eye through a blue filter.

Urologic aspects of tethered cord.

Tethered cord syndrome, a form of spinal dysrhaphism, may involve vesical neurologic dysfunction. We present herein 60 cases of tethered cord syndrome, including 24 patients who underwent preoperative urodynamics studies. Preoperative cystometrography revealed areflexic bladders in 71 percent of cases and hyperreflexic bladders in 29 percent.

Undiversion using ileocecocystoplasty in a case of retroperitoneal hemorrhage after cardiac catheterization.

We performed urinary undiversion using ileocecocystoplasty in a patient who sustained bladder and ureteral necrosis secondary to transfemoral cardiac catheterization.