Unusual role in occlusion and mastication of a horizontal positioned erupted mandibular third molar: a rare case.

Lower third molars are frequently extracted due to pathologies of the dental follicle, pericoronitis, advanced carious lesions, orthodontic reasons (risk of anterior tooth crowding) or causing periodontal or carious lesions in the distal area of the second molar. The case presented here is of a male patient that came to our Clinic experiencing pain in the distal area of one of his old bridges. The clinical examination revealed a malpositioned, but unusually functional third molar; it is a very rare situation for an initially impacted third molar to erupt in an almost horizontal position and not only to remain on the arch for a very long period of time, but also to contribute to mastication efficiency and occlusion, despite the fact that masticatory forces are distributed at a right angle on its long axis and that mastication takes place on the distal surface of the crown and root, and not on the usually occlusal cusped surface.

Effect of a harmonic surface pressure on wave propagation over a beach.

The objective is to study the harmonic forced wave motion over a beach by a finite Fourier transform technique. The constructed approximate solution has a logarithmic singularity at the shoreline. It accounts for reflexion and local perturbations.

Orthodontic treatment of a non-syndromic patient with congenital agenesis of multiple permanent teeth: a rare case.

This article presents the first stage of treatment, respectively the orthodontic management of a non-syndromic, 13-year-old patient, with multiple and asymmetric missing teeth. The difficulty of the case was increased by the association of an impacted premolar and also by the loss, due to extended caries, of three of the first permanent molars. The patient came from a rural area, where access to dental treatment was limited.

Clinical Validation of a Targeted Next-Generation Sequencing Panel for Lymphoid Malignancies.

Lymphoid malignancies are a heterogeneous group of hematological disorders characterized by a diverse range of morphologic, immunophenotypic, and clinical features. Next-generation sequencing (NGS) is increasingly being applied to delineate the complex nature of these malignancies and identify high-value biomarkers with diagnostic, prognostic, or therapeutic benefit. However, there are various challenges in using NGS routinely to characterize lymphoid malignancies, including pre-analytic issues, such as sequencing DNA from formalin-fixed, paraffin-embedded tissue, and optimizing the bioinformatic workflow for accurate variant calling and filtering.

Multiple wave scattering by submerged obstacles in an infinite channel of finite depth with surface pressure excess.

The objective is to study the combined effect of an incident wave, a surface pressure excess and a finite number of submerged obstacles, in the phenomenon of power transfer to an infinite fluid layer of finite depth. The incident wave and the surface pressure excess have the same harmonic time dependence, a fact that allows to eliminate time altogether and consider only steady-state solutions. The surface pressure excess simulates the effect of winds blowing above the water surface in oceans.

A rare find of a maxillary third molar with five roots: a case report of an unusual morphology.

Third molars are frequently absent or impacted; their unpredictable prevalence and morphology, with frequent anatomical variations, is a challenge for the practitioner. The number of roots of the upper third molars vary from one to five, but five roots upper third molars' cases are extremely rare. The case reported here is of a normotrophic male patient, with no significant general medical history, having extracted an impacted maxillary upper molar, with an unusual position and dimensions and five completely separated formed roots, orientated in diverse directions.

Nonlinear Rayleigh wave propagation in a layered half-space in dual-phase-lag.

We investigate nonlinear Rayleigh wave propagation in a layered thermoelastic medium composed of a slab rigidly bonded to the surface of a half-space under prescribed external thermal boundary conditions within the dual-phase-lag theory. The heat conduction coefficient for both the slab and the matrix have a linear dependence on temperature. Our aim is to assess the effect of temperature dependence of the heat conductivity, as well as the thermal relaxation times, on the process of wave propagation in the layered medium.

Nonlinear Rayleigh wave propagation in thermoelastic media in dual-phase-lag.

A model of generalized thermoelasticity within dual-phase-lag is used to investigate nonlinear Rayleigh wave propagation in a half-space of a transversely isotropic elastic material. It is assumed that the coefficient of heat conduction is temperature-dependent, a fact that plays an important role in the coupling behaviour analysis of thermoelastic and piezo-thermoelastic solids. Taking such a dependence into account becomes a necessity at higher temperatures and in nano-structures, when the material properties can no longer be considered as constants.

On a two-dimensional model of generalized thermoelasticity with application.

A 2D first order linear system of partial differential equations of plane strain thermoelasticity within the frame of extended thermodynamics is presented and analyzed. The system is composed of the equations of classical thermoelasticity in which displacements are replaced with velocities, complemented with Cattaneo evolution equation for heat flux. For a particular choice of the characteristic quantities and for positive thermal conductivity, it is shown that this system may be cast in a form that is symmetric t-hyperbolic without further recurrence to entropy principle.

Unilateral agenesis of permanent superior canine in familial peg-shaped lateral incisors: rare case report and literature review.

Agenesis of permanent maxillary and mandibular canines is very rare; one to all four can be missing, isolated or in association with other missing teeth or with dental morphology abnormalities. Such cases can present functional, esthetic, and psychological problems, since the canine's role in functional occlusion and in obtaining an aesthetic smile is crucial. Frequently, the canine's absence from the arch is caused by impaction; its congenital absence is extremely rare in patients with no associated syndrome.

A rare case of transmigrated mandibular canine and combined orthodontic-surgical management.

Canines are paramount teeth for esthetics and function. Transmigration of the lower permanent canine is a rare process of alteration of the eruption path toward the opposite part of the mandible. The position of the migrating tooth varies at different ages, so early detection of the tendency to cross the midline is crucial; canines that have already passed through the center of the mandible can be impossible to realign.

Supernumerary permanent maxillary canine - a rare finding: case report and literature review.

Supernumerary teeth are dental units that appear in addition to the regular number of teeth. Their most frequent location is the anterior maxilla, especially on the maxillary midline, being called mesiodens, but also paramedian or in the position of a lateral incisor. On the other hand, the permanent canine is one of the most stable teeth regarding the number, with very few cases reported about hypo- or hyperdontia.

Enhanced hyaluronic acid production in by an optimized culture medium containing hyaluronidase inhibitor.

This study describes the hyaluronic acid (HA) production by ATCC 43079, and the effect of the hyaluronidase enzyme on HA levels. The hyaluronidase production, glucose consumption, and lactate formation were recorded during fermentation. The HA production, and productivity at different amounts of glucose, yeast extract and pH were evaluated by response surface statistical approach in presence of 6-O-palmytoil--ascorbic acid as a chemical inhibitor for biocatalyst hyaluronidase.

Base Materials' Influence on Fracture Resistance of Molars with MOD Cavities.

The aim of this study was to compare fracture resistance of teeth presenting medium-sized mesial-occlusal-distal (MOD) cavities using different base materials. Thirty-six extracted molars were immersed for 48 h in saline solution (0.1% thymol at 4 °C) and divided into six groups.

Periodontal clinico-morphological changes in patients wearing old nickel-chromium and copper alloys bridges.

Elderly population frequently presents more than one prosthetic restoration realized from different types of dental alloys which, in time, suffer various alterations in the oral environment. Metallic ions are released in saliva due to its electrolytic qualities, interacting with the contact tissues. Studies regarding cytotoxicity of dental alloys are providing contradictory results.

Non-syndromic familial hypodontia: rare case reports and literature review.

Congenital absence of the teeth, affecting both physiognomy and mastication, can have a great impact on patients' quality of life. It may appear unilateral or bilateral; frequently, it associates with certain general conditions. Familial hypodontia in clinically healthy patients is rare.

SERPINA1 Full-Gene Sequencing Identifies Rare Mutations Not Detected in Targeted Mutation Analysis.

Genetic α-1 antitrypsin (AAT) deficiency is characterized by low serum AAT levels and the identification of causal mutations or an abnormal protein. It needs to be distinguished from deficiency because of nongenetic causes, and diagnostic delay may contribute to worse patient outcome. Current routine clinical testing assesses for only the most common mutations.

Heterogenous MSH6 loss is a result of microsatellite instability within MSH6 and occurs in sporadic and hereditary colorectal and endometrial carcinomas.

Mismatch-repair (MMR) immunohistochemistry is used to detect tumor MMR deficiency associated with high-level microsatellite instability (MSI). Rare tumors show heterogenous loss of mutS homolog 6 (MSH6) with immunohistochemistry, defined by areas of retained staining and separate areas of complete loss of staining. To investigate the clinical interpretation of this phenomenon, we identified 22 cases of heterogenous MSH6 loss interpreted at Mayo Clinic from January 2001 through December 2012 and reviewed histologic features, MSH6 and other MMR immunohistochemistry, and accompanying MSI testing results (n=20).

Pontic morphology as local risk factor in root decay and periodontal disease.

Introduction: In absence of treatment, old single edentulous spaces are subjected to progressively decrease in length due to tilting and rotation of the teeth situated mesial and distal. Lately when these spaces are prosthetically restored with a bridge and these teeth are becoming abutments, sanitizing of the prosthetic restoration is achieved with difficulty, the space between the pontic and the gingival surface becoming an area rich in pathogens that can cause various complications on the abutments.

Aim: Considering these aspects, in this study we wanted to highlight the presence and the types of the microorganisms that can be found under the pontic even in an ideal situation, selecting only young adult patients with a good oral hygiene and only with metal-ceramic bridges.

Systemic transthyretin amyloidosis in a patient with bent spine syndrome.

Wild-type and mutant transthyretin (TTR) are implicated in systemic amyloidosis (ATTR). Myopathy is a rare complication of ATTR amyloidosis, however no patient with bent spine syndrome secondary to ATTR amyloidosis has been reported so far. We present the first case of bent spine syndrome in a patient with wild-type ATTR amyloidosis who also had concomitant Alzheimer's disease.

GDC-0449-a potent inhibitor of the hedgehog pathway.

SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway. The 2-pyridyl amides were optimized for potency, PK, and drug-like properties by modifications to the amide portion of the molecule resulting in 31 (GDC-0449). Amide 31 produced complete tumor regression at doses as low as 12.

A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.

Discovery of a highly selective, potent, and safe non-carboxylic acid, non-hydantoin inhibitor of aldose reductase (AR) capable of potently blocking the excess glucose flux through the polyol pathway that prevails under diabetic conditions has been a long-standing challenge. In response, we did high-throughput screening of our internal libraries of compounds and identified 6-phenylsulfonylpyridazin-2H-3-one, 8, which showed modest inhibition of AR, both in vitro and in vivo. Initial structure-activity relationships concentrated on phenyl substituents and led to 6-(2,4-dichlorophenylsulfonyl)-2H-pyridazin-3-one, 8l, which was more potent than 8, both in vitro and in vivo.

A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.

We report here on the discovery path that led to a structurally unprecedented non-hydantoin, non-carboxylic acid aldose reductase inhibitor, 24, which shows remarkably potent oral activity in normalizing elevated sorbitol levels and, more significantly, fructose levels in the sciatic nerve of chronically diabetic rats, with ED(90) values of 0.8 and 3 mpk, respectively. It is well absorbed in rats (oral bioavailability, 98%) and has a long plasma t(1/2) (26 +/- 3 h).

Sorbitol dehydrogenase inhibitors (SDIs): a new potent, enantiomeric SDI, 4-[2-1R-hydroxy-ethyl)-pyrimidin-4-yl]piperazine-1-sulfonic acid dimethylamide.

We report here on our medicinal chemistry and pharmacology efforts to provide a potent sorbitol dehydrogenase inhibitor (SDI) as a tool to probe a recently disclosed hypothesis centered on the role of sorbitol dehydrogenase (SDH) in the second step of the polyol pathway, under conditions of high glucose flux. Starting from a weak literature lead, 2, and through newly developed structure-activity relationships, we have designed and executed an unambiguous synthesis of enantiomeric SDI, 6, which is at least 10x more potent than 2. Also, 6 potently inhibits SDH in streptozotocin-diabetic rat sciatic nerve.