Binding of an SV40 T antigen-related protein to the DNA of SV40 regulatory mutants.

When simian virus 40 (SV40) infects host cells, the viral genes are expressed in two phases. Early in infection, the virus genome is transcribed and translated to yield two related proteins, 'large T' and 'small t' antigens. Later the rate of synthesis of the early messenger RNA falls and the viral genes coding for the coat proteins are transcribed and translated.

A nicked form of kinetoplast DNA in Leishmania tarentolae.

The mitochondrial DNA of the protozoan Leishmania tarentolae, known as kinetoplast DNA, contains thousands of minicircles linked in a two-dimensional network. When kinetoplast DNA from exponentially growing cells is centrifuged to equilibrium in a CsCl/ethidium bromide gradient, it is resolved into two discrete components, Form I and Form II. Nearly all of the minicircles in Form I networks are covalently closed and all of those in Form II networks are open.

Traumatic death in urban children.

Trauma has remained one of the leading causes of death in children in spite of improved medical care. A review of 911 pediatric trauma deaths which occurred over a 5 yr period in an urban setting revealed that almost 50% of these children died before receiving medical care. A significant improvement of the trauma mortality can thus only be accomplished by reducing the number of "DOAs".