Machine-Learning Based Computed Tomography Radiomics Nomgram For Predicting Perineural Invasion In Gastric Cancer.

Objective: The aim of this study was to develop and validate predictive models for perineural invasion (PNI) in gastric cancer (GC) using clinical factors and radiomics features derived from contrast-enhanced computed tomography (CE-CT) scans and to compare the performance of these models.

Methods: This study included 205 GC patients, who were randomly divided into a training set (n=143) and a validation set (n=62) in a 7:3 ratio. Optimal radiomics features were selected using the least absolute shrinkage and selection operator (LASSO) algorithm.

Study on the Bending and Shear Behavior of a New Type of Wet Joint in Precast Concrete Deck for Composite Bridges.

According to the mechanical characteristics of joints in steel-concrete composite bridge decks under the combined bending and shear, improved joint details with simple structure and convenient construction were studied, including lapped U-bars, lapped headed bars, and lapped hook bars. In order to test the mechanical properties of the three joint details and compare them with the existing lapped/welded linear bars, the tests of five specimens were carried out. The cracking load, ultimate load, failure mode, crack pattern, and reinforcement strain were analyzed.

Investigation of Shear Behavior in High-Strength Bolt Connectors for Steel-Concrete Composite Beams.

High-strength bolt connectors, known for their robust strength and ease of disassembly, are suitable not only for the construction of new steel-concrete composite beams but also for reinforcing existing composite or steel beams. Static push-out tests were performed on nine specimens to examine their shear behavior. The primary failure mode was observed at the steel-concrete interface, characterized by the tensile-shear failure of the bolt and localized crushing of the concrete beneath the bolt.

Case Report: A Young Woman Diagnosed With Overlap Syndrome of Systemic Sclerosis and Ankylosing Spondylitis.

This case report describes a rare occurrence of a 25-year-old female diagnosed with both systemic sclerosis (SSc) and ankylosing spondylitis (AS), two distinct autoimmune diseases. The patient presented with a combination of symptoms, including progressive skin tightening, lumbosacral pain, and Raynaud's phenomenon, which complicated the diagnosis. Despite the challenges posed by the coexistence of SSc and AS, a multidisciplinary treatment approach involving corticosteroids, immunosuppressants, and supportive therapies led to significant clinical improvement.

Case Report: A Ticking Time Bomb: Femoral Artery Aneurysm as a Complication of Behcet's Disease in Adolescents.

Behcet's disease is a rare, chronic inflammatory disorder that can affect various organs, with large vessel involvement being particularly uncommon. This case report discusses a 17-year-old male with Behcet's disease who presented with a rapidly enlarging, painful mass in the right groin region, later diagnosed as a femoral artery aneurysm. The patient underwent successful surgical intervention and was subsequently managed with immunosuppressive therapy to prevent relapse.

Early screening to identify and diagnose primary nasal tuberculosis in patients with tumor necrosis factor inhibitors.

In this editorial, we comment on the article by Liu . Based on our analysis of a case report, we consider that early screening and recognition of primary nasal tuberculosis are crucial for patients undergoing treatment with tumor necrosis factor inhibitor (TNFi). While TNFi therapy increases the risk of reactivating latent tuberculosis, primary nasal tuberculosis remains rare due to the protective mechanisms of the nasal mucosa.

Experimental Study on Seismic Behavior of Concrete-Filled Steel Tube with Spherical-Cap Gap.

Concrete-filled steel tubes (CFST) are widely used due to their high strength, ductility, and energy dissipation capacity. However, gaps in between core concrete and steel tube adversely affect the mechanical performance of structures, thereby compromising the safety of the building. In this paper, four concrete-filled steel tube specimens with spherical-cap gaps were designed, and quasi-static tests were conducted to investigate the impact of gap depth on the seismic performance of concrete-filled steel tube columns.

Design and synthesis of FeS/graphite sandwich structure with enhanced lithium-storage performance for lithium-ion and solid-state lithium batteries.

As a conversion-type cathode material, FeS emerges as a promising candidate for the next generation of energy storage solutions, attributed to its cost-effectiveness, environment-friendliness and high theoretical capacity. However, several challenges hinder its practical application, including sluggish kinetics, insulating reaction products and significant volume fluctuation during cycling, which collectively compromise its rate capability and cycle stability. Herein, a well-designed sandwich structure of FeS embedded between graphite layers (FeS/C) is obtained using a chloride intercalation and sulfidation strategy.

Origins of synergy in multilipid lubrication.

Lipid bilayers, ubiquitous in living systems, form lubricious boundary layers in aqueous media, with broad relevance for biolubrication, especially in mechanically stressed environments such as articular cartilage in joints, as well as for modifying material interfacial properties. Model studies have revealed efficient lubricity by single-component lipid bilayers; synovial joints, however (e.g.

Efficient Synthesis of Flower-Ball Structured CuFeS as Advanced Anode Material for Lithium-Ion Batteries Across Wide Temperature Ranges.

Transition metal sulfides stand as potential anode candidates for lithium-ion batteries offering high capacity, redox reversibility, and safety. However, cycling-induced volume variations and slow kinetics hinder their application. Here, CuFeS with a flower-ball nanosheet structure is synthesized via a hydrothermal method, enhancing electrolyte infiltration, Li transport, and cycle life.

Alterations of Nutrient Elements in Hepatocellular Carcinoma Patients Treated with Atezolizumab-Bevacizumab.

Currently, the combination of atezolizumab and bevacizumab (Atez/Bev) is recommended as the first-line therapy for patients with advanced hepatocellular carcinoma (HCC). However, there is a lack of research on the levels of nutrient elements in advanced HCC patients receiving Atez/Bev treatment. In this study, data from 35 patients with advanced HCC and 37 healthy individuals of similar age and sex were included.

Enhanced Sensitivity of Cell Identification in Complex Environments Using Chirally Inverted L-DNA-Based Logic Devices.

Accurate identification and isolation of target cells are crucial for precision diagnosis and treatment. DNA aptamer-based logic devices provide a distinct advantage in this context, as they can logically analyze multiple cell surface markers with high efficiency. However, the susceptibility of natural DNA (D-DNA) to degradation can compromise the sensitivity and specificity of these devices, potentially leading to false-positive and false-negative results, particularly in complex biological environments.

Medical dilemma: Programmed death 1 blockade (sintilimab) therapy in patients suffering from tumours combined with psoriasis.

Tumour immunotherapy represented by immune checkpoint inhibitors (ICIs) has greatly improved the overall prognosis of patients with malignant tumours, and is regarded as an important breakthrough in the field of medicine in recent years. ICIs have gradually become the core of tumour therapy and are increasingly used in the clinic. In order to achieve early clinical prediction and management of immune-related adverse events (irAEs), it is still necessary to perform further research on the mechanisms, risk factors, and predictors of irAE occurrence in the future.

Backdoor attacks on unsupervised graph representation learning.

Unsupervised graph learning techniques have garnered increasing interest among researchers. These methods employ the technique of maximizing mutual information to generate representations of nodes and graphs. We show that these methods are susceptible to backdoor attacks, wherein the adversary can poison a small portion of unlabeled graph data (e.

Lysophosphatidic acid improves development of porcine somatic cell nuclear transfer embryos.

This study was conducted to investigate whether lysophosphatidic acid (LPA) could improve the development of porcine somatic cell nuclear transfer (SCNT) embryos. Porcine SCNT-derived embryos were cultured in chemically defined polyvinyl alcohol (PVA)-based porcine zygote medium (PZM)-4 without or with LPA, and the development, cell proliferation potential, apoptosis, and expression levels of pluripotent markers were evaluated. LPA significantly increased the rates of cleavage and blastocyst formation compared to those seen in the LPA un-treatment (control) group.

Mismatch Negativity and P300 in the Diagnosis and Prognostic Assessment of Coma and Other Disorders of Consciousness.

Background: The objective of this study was to investigate the value of mismatch negativity (MMN) and P300 event-related potentials for discriminating the consciousness state and predicting improvement of consciousness at 6 months in patients with coma and other disorders of consciousness (DOC).

Methods: We performed MMN and P300 on 42 patients with DOC with a mean onset time of 40.21 ± 19.

Impact of previous COVID-19 infection on postoperative complications and functional recovery: a one-year follow-up ambispective cohort study.

Background: It's necessary to reassess the patients' short-term and long-term postoperative outcome in the post-COVID-19 era. This study aims to provide more comprehensive evidence regarding the timing of surgery after COVID-19 infection among the vaccinated population upon Omicron variant, considering the duration after acute COVID-19 infection, severity of COVID-19, patients' comorbidities, and the full course quality of postoperative recovery.

Materials And Methods: This is a single-center cohort study.

Cell-inspired, massive electromodulation of friction via transmembrane fields across lipid bilayers.

Transient electric fields across cell bilayer membranes can lead to electroporation and cell fusion, effects crucial to cell viability whose biological implications have been extensively studied. However, little is known about these behaviours in a materials context. Here we find that transmembrane electric fields can lead to a massive, reversible modulation of the sliding friction between surfaces coated with lipid-bilayer membranes-a 200-fold variation, up to two orders of magnitude greater than that achieved to date.

Effect of the combined intervention of low-FODMAPs diet and probiotics on IBS symptoms in Western China: A randomized controlled trial.

The effect of low-FODMAPs diet on irritable bowel syndrome (IBS) in Western China has not been reported. We aimed to investigate the effect of low-FODMAPs diet on IBS patients in the area and whether low-FODMAPs diet-induced alterations of microbiota could be improved through probiotics. IBS patients were randomized to the control group, low-FODMAPs diet group, probiotics group, or combined group.

2D Graphene Oxide Films Expand Functionality of Photonic Chips.

On-chip integration of 2D materials with unique structures and properties endow integrated devices with new functionalities and improved performance. With high flexibility in ways to modify its properties and compatibility with integrated platforms, graphene oxide (GO) is an exceptionally attractive 2D material for hybrid integrated photonic chips. Here, by harnessing unique property changes induced by photothermal effects in 2D GO films, novel functionalities beyond the capability of photonic integrated circuits are demonstrated.

Unveiling mitochondrial and ribosomal gene deregulation and tumor microenvironment dynamics in acute myeloid leukemia.

Acute myeloid leukemia (AML) is a malignant clonal hematopoietic disease with a poor prognosis. Understanding the interaction between leukemic cells and the tumor microenvironment (TME) can help predict the prognosis of leukemia and guide its treatment. Re-analyzing the scRNA-seq data from the CSC and G20 cohorts, using a Python-based pipeline including machine-learning-based scVI-tools, recapitulated the distinct hierarchical structure within the samples of AML patients.

Experimental and Numerical Study of Membrane Residual Stress in Q690 High-Strength Steel Welded Box Section Compressed Member.

High-strength steel (HSS) members with welded sections exhibit a notably lower residual compressive stress ratio compared with common mild steel (CMS) members. Despite this difference, current codes often generalize the findings from CMS members to HSS members, and the previous unified residual stress models are generally conservative. This study focuses on the membrane residual stress distribution in Q690 steel welded box sections.