Chrysomycin A Reshapes Metabolism and Increases Oxidative Stress to Hinder Glioblastoma Progression.

Glioblastoma represents the predominant and a highly aggressive primary neoplasm of the central nervous system that has an abnormal metabolism. Our previous study showed that chrysomycin A (Chr-A) curbed glioblastoma progression in vitro and in vivo. However, whether Chr-A could inhibit orthotopic glioblastoma and how it reshapes metabolism are still unclear.

Progress on metabolites of Astragalus medicinal plants and a new factor affecting their formation: Biotransformation of endophytic fungi.

It is generally believed that the main influencing factors of plant metabolism are genetic and environmental factors. However, the transformation and catalysis of metabolic intermediates by endophytic fungi have become a new factor and resource attracting attention in recent years. There are over 2000 precious plant species in the Astragalus genus.

Efficacy and safety of autologous platelet-rich plasma for diabetic foot ulcers: a systematic review and meta-analysis.

Objective: To investigate the efficacy and safety of autologous platelet-rich plasma (au-PRP) for diabetic foot ulcer (DFU) treatment.

Method: We conducted database searches (MEDLINE, EMBASE, evidence-based medicine reviews: CENTRAL, PubMed, and Web of Science) and reference mining for randomised controlled trials from inception to 23 January 2022. Results were scrutinised, data were extracted and research quality was investigated by two independent authors.

Molecular Epidemiology, Microbial Virulence, and Resistance of Carbapenem-Resistant Isolates in a Teaching Hospital in Guangzhou, China.

Infection caused by carbapenem-resistant (CRE) is a global public health problem. We performed whole-genome sequencing to investigate the molecular epidemiological characteristics of local CRE infections and understand the prevalence of hypervirulent carbapenem-resistant (CRKP). Analysis of multiLocus sequence typing (MLST), antibiotic resistance genes, plasmid replicons, virulence genes, and the genetic environment was also performed.

A long-tailed marine reptile from China provides new insights into the Middle Triassic pachypleurosaur radiation.

Pachypleurosaurs (Pachypleurosauroidea) are a group of small to medium-sized, lizard-like marine reptiles in the Early to Middle Triassic, including Pachypleurosauridae, Keichousauridae and closely related taxa. The group is generally considered as a sauropterygian radiation, but its phylogenetic interrelationships remain highly debated. Here, we present a new pachypleurosaurid, Honghesaurus longicaudalis gen.

Emergence of Clinical Isolate Guangzhou-PaeC79 Carrying , , and in Guangzhou of China.

As a potential "Superbug," remains the leading concern in antimicrobial resistance. In this study, the emergence of clinical isolate was found to carry and on the chromosome and on a plasmid. A clinical strain Guangzhou-PaeC79 with an extensively drug-resistant phenotype was isolated, which was resistant to all classes of clinical commonly used antibiotics.

Integron mediated bacterial resistance and virulence on clinical pathogens.

Integron was recognized as mobile elements responsible for the emergence and diffusion of antibiotic resistance, virulence and pathogenicity. The existence of resistant integron in pathogens may consequently lead to the increasing number of clinical failures in bacterial mediated diseases, as well as the expenses. In this study, a total of 22 clinical pathogens (including E.

Comparison of titanium cable tension band and nickel-titanium patella concentrator for patella fractures.

Background: Patellar fractures account for approximately 1% of all fractures. Due to the patella's importance as regards the extensor mechanism, effort should be made to preserve the patella. Several operative treatment methods have been introduced for patella fractures.

MicroRNA-145 Mediates Steroid-Induced Necrosis of the Femoral Head by Targeting the OPG/RANK/RANKL Signaling Pathway.

Objective: To investigate the role of microRNA-145 (miR-145) in steroid-induced necrosis of the femoral head (SINFH) by evaluating its effects on the OPG/RANK/RANKL signaling pathway.

Methods: A rat model of SINFH was constructed via injection of the lentiviral vector pLV-shRNA-miR-145. Pathological observation was performed via tartrate-resistant acid phosphatase (TRAP) staining, and serum OPG levels were detected by ELISA.

Non-Markovian Complexity in the Quantum-to-Classical Transition.

The quantum-to-classical transition is due to environment-induced decoherence, and it depicts how classical dynamics emerges from quantum systems. Previously, the quantum-to-classical transition has mainly been described with memory-less (Markovian) quantum processes. Here we study the complexity of the quantum-to-classical transition through general non-Markovian memory processes.

Fabrication of hydroxyapatite on pure titanium by micro-arc oxidation coupled with microwave-hydrothermal treatment.

Porous hydroxyapatite (HA)-containing composite films were prepared by a novel method consisting of micro-arc oxidation (MAO) combined with microwave-hydrothermal (M-H) treatment. The morphology, composition and phase composition of the bioactive films were investigated with scanning electron microscopy with energy dispersive X-ray spectroscopy and X-ray diffraction. MTT assay was carried out to investigate the in vitro effects of the different surfaces on bone integration properties.

Association analysis between the OPG g.27667T>A genetic variant and bone mineral density in Chinese postmenopausal women.

The purpose of this study was to investigate the association of the g.27667T>A genetic variant in the osteoprotegerin (OPG) gene with bone mineral density (BMD) and osteoporosis. A total of 393 primary osteoporosis subjects and 402 healthy controls were recruited.

[Combined immunoprophylaxis induces changes in anti-hepatitis B surface protein titer in infants born to mothers with positivity for hepatitis B surface antigen].

Objective: To conduct a prospective randomized controlled trial of infants born to hepatitis B virus (HBV) surface antigen (HBsAg)-positive mothers in order to investigate the dynamic changes in the titer of anti-HBV surface protein (HBS) induced by treatment with combined immunoprophylaxis (200 IU hepatitis B immunoglobulin (HBIG) and 5 or 10 mug yeast recombinant hepatitis B vaccine), to compare the protective effect of 5 and 10 mug hepatitis B vaccine, and to provide an immunization strategy, monitoring mode and booster immunization schedule for the high-risk group.

Methods: Two-hundred-and-sixty-nine infants born to HBsAg positive mothers were given combined immunoprophylaxis at birth, and the venous blood samples (at birth, and 1, 7 and 12 months) were tested for HBV DNA load, and HBsAg and anti-HBS titers.

Results: The overall 1-year protective rate of combined immunoprophylaxis was 95.

Endothelial progenitor cells: therapeutic perspective for ischemic stroke.

Endothelial progenitor cells (EPCs), which can be cultured in vitro from mononuclear cells in peripheral blood or bone marrow, express both hematopoietic stem cell and endothelial cell markers on their surface. They are believed to participate in endothelial repair and postnatal angiogenesis due to their abilities of differentiating into endothelial cells and secreting protective cytokines and growth factors. Mounting evidence suggests that circulating EPCs are reduced and dysfunctional in various diseases including hypertension, diabetes, coronary heart disease, and ischemic stroke.

Dipole, quadrupole and octupole plasmon resonance modes in non-concentric nanocrescent/nanodisk structure: local field enhancement in the visible and near infrared regions.

By deviating the nanodisk from the center in the silver nanocrescent/nanodisk structure, we find that the dipole, quadrupole and octupole modes can all induce very high local electric field enhancement (LFE, more than 750) for the coupling of nanocrescent and crescent gap modes, which makes the resonant wavelengths of the non-concentric nanostructures change from the visible to near infrared regions. In addition, the LFE factor of the quadrupole mode is more than 1000, which is suitable for single molecular detection by local surface enhanced spectroscopy.

Periodic nanoripples in the surface and subsurface layers in ZnO irradiated by femtosecond laser pulses.

We present the formation of periodic ripples in ZnO crystal irradiated by a wavelength-tunable femtosecond laser. The results indicate that in the surface thin layer, the periods change from 0.1 lambda to lambda with laser fluences and pulse numbers, and in the subsurface layer the periods are always lambda/2n, where n is the refractive index.

Nonequilibrium nuclear-electron spin dynamics in semiconductor quantum dots.

We study the spin dynamics in charged quantum dots in the situation where the resident electron is coupled to only about 200 nuclear spins and where the electron spin splitting induced by the Overhauser field does not exceed markedly the spectral broadening. The formation of a dynamical nuclear polarization as well as its subsequent decay by the dipole-dipole interaction is directly resolved in time. Because not limited by intrinsic nonlinearities, almost complete nuclear polarization is achieved, even at elevated temperatures.

Electron spin dynamics in a self-assembled semiconductor quantum dot: the limit of low magnetic fields.

Using the trion as an optical probe, we uncover novel electron spin dynamics in CdSe/ZnSe Stranski-Krastanov quantum dots. The longitudinal spin lifetime obeys an inverse power law associated with recharging processes in the dot ensemble. No hint at spin-orbit mediated spin relaxation is found.

A tale of two speeds: challenges for research universities.

This manuscript represents a presentation to the Annual Conference of the Association of Anatomy, Cell Biology and Neurobiology Chairpersons. The author is responding to the question, "How can university administrations nurture both interdisciplinary and inter-institutional collaboration and cooperation?" The presentation makes the point that university administrators must be cognizant of the changing dynamics of interdisciplinary and inter-institutional collaboration and cooperation due to the speed of the Internet and the speed of travel today. Those institutional leaders, and their universities, that recognize that the world has become flat will flourish, while those locked in a silo mentality will perish.

Incoherent subharmonic light scattering in isotropic media.

Incoherent subharmonic light scattering in isotropic media is a new kind of nonlinear light scattering, which involves single input photon and multiple output photons of equal frequency. We investigate theoretically the dependence of the subharmonic scattering intensity on the hyperpolarizability of molecules and the incident intensity using nonlinear optics theory similar to that used for Hyper-Rayleigh scattering and degenerate optical parametric oscillators. It is derived that the subharmonic scattering intensities grow exponentially or superexponentially with the hyperpolarizability of molecules and the incident intensity.

Virtual bronchoscopy: segmentation method for real-time display.

Computed tomography (CT) data sets obtained in 14 patients were used in a segmentation method for virtual bronchoscopy (VB). The method constrained the distance of propagation of a region-growing algorithm. The resulting three-dimensional bronchial model was a faithful representation of the source CT data and could be manipulated in real time at frame rates of one to two frames per second.