Upper gastrointestinal bleeding from a Mallory-Weiss tear associated with transesophageal echocardiography during successful cardiopulmonary resuscitation: A case report.

Background: In recent years, it has been recognized that transesophageal echocardiography (TEE) is of great value in resuscitation of cardiac arrest. However, its safety has rarely been reported.

Case Summary: We present a 59-year-old male patient scheduled to undergo cardiac surgery for rheumatic heart disease.

Hypothermic preconditioning but not ketamine reduces oxygen and glucose deprivation induced neuronal injury correlated with downregulation of COX-2 expression in mouse hippocampal slices.

Hypothermic preconditioning is an effective treatment for limiting ischemic injury, but the mechanism is poorly understood. This study was aimed to explore the effect of hypothermic and ketamine preconditioning on oxygen and glucose deprivation (OGD) induced neuronal injury in mouse hippocampal slices, and to investigate its possible mechanism. The population spike (PS) was recorded in the CA1 region of mouse hippocampal slices using extracellular recordings, Na/K ATPase activity in slices was determined by spectrophotometer and the expression of Cyclooxygenase-2 (COX-2) was measured by Western blot.

Evidence for negative thermal expansion in the superconducting precursor phase SmFeAsO.

The fluorine-doped rare-earth iron oxypnictide series SmFeAsO F (0 [Formula: see text] 0.10) was investigated with high resolution powder x-ray scattering. In agreement with previous studies (Margadonna et al 2009 Phys.

Involvement of N-Methyl-D-Aspartic Acid Receptor and DL-α-Amino-3-Hydroxy-5- Methyl-4-Isoxazole Propionic Acid Receptor in Ginsenosides Rb1 and Rb3 against Oxygen-Glucose Deprivation-Induced Injury in Hippocampal Slices from Rat.

Objective: Ginsenosides, Rb1 and Rb3, are the major protopanaxadiol components of ginseng saponin. In the present study, the influences of ginsenosides Rb1 and Rb3 on N-methyl-D-aspartic acid (NMDA) receptor or DL-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-mediated synaptic transmission after oxygen-glucose deprivation (OGD) were investigated.

Methods: NMDA receptor population spike (NMDA-PS) or AMPA receptor-mediated population spike (AMPA-PS) was recorded in the CA1 pyramidal cell layer of rat hippocampal slices by electrophysiological techniques.

[The Role of Bone Morphogenic Protein-4 in the Progression of Vein Graft Hyperplastic Remodeling under Hyperglycemic Condition].

Objective: This study was designed to assess the vessel wall characteristics and the expression levels of bone morphogenic protein4(BMP4) and proliferating cell antigen Ki67 in vein grafts harvested from diabetic rats,and to investigate the role of BMP4 in progression of vein graft hyperplastic remodeling under hyperglycemic condition.

Methods: 48 male SpragueDawky rats [body mass (194±16) g] aged 8 weeks were randomly divided into diabetes mellitus (DM) group ( =24) and nondiabetes mellitus (NDM) group ( =24). The DM rats were induced by streptozotocin in combination with highsugar and highfat diet.

Shear-Induced Precursor Relaxation-Dependent Growth Dynamics and Lamellar Orientation of β-Crystals in β-Nucleated Isotactic Polypropylene.

Although a shear flow field and β-nucleating agents (β-NAs) can separately induce the formation of β-crystals in isotactic polypropylene (iPP) in an efficient manner, we previously encountered difficulty in obtaining abundant β-crystals when these two factors were applied due to the competitive growth of α- and β-crystals. In the current study, to induce the formation of a high fraction of β-crystals, a strategy that introduces a relaxation process after applying a shear flow field but before cooling to crystallize β-nucleated iPP was proposed. Depending on the relaxation state of the shear-induced oriented precursors, abundant β-crystals with a refined orientation morphology were indeed formed.

NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.

CD40, a member of tumour necrosis factor receptor (TNFR) superfamily, has a pivotal role in B-cell-mediated immunity through various effector pathways including AKT kinase, but the signal transduction of CD40-meidated AKT activation is poorly understood. Here we report that the neural precursor cell expressed developmentally downregulated protein 4 (NEDD4), homologous to E6-AP Carboxyl Terminus family E3 ubiquitin ligase, is a novel component of the CD40 signalling complex. It has a key role in CD40-mediated AKT activation and is involved in modulating immunoglobulin class switch through regulating the expression of activation-induced cytidine deaminase.

Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer.

CUEDC2, a CUE-domain-containing protein, modulates inflammation, but its involvement in tumorigenesis is still poorly understood. Here, we report that CUEDC2 is a key regulator of macrophage function and critical for protection against colitis-associated tumorigenesis. CUEDC2 expression is dramatically upregulated during macrophage differentiation, and CUEDC2 deficiency results in excessive production of proinflammatory cytokines.

[Survey of the coverage and influencing factors of pit and fissure sealants in primary and middle school of Hangzhou city].

Purpose: To investigate the coverage of pit and fissure sealants in primary and middle school students of Hangzhou city, and to explore the causes of unsealing students.

Methods: An analysis of sealing rate and unsealing causes of eligible children in Hangzhou city was carried out, using 3-year data of pit and fissure sealants program sponsored by the government. Based on the results, the validity of pit and fissure sealants as a government-sponsored public health program was evaluated.

Preliminary report on use of 3-dimensional computed tomographic images in a disease-based transesophageal echocardiographic simulation system.

We used 3-dimensional computed tomographic images to create a disease-based transesophageal echocardiographic simulation system for complex congenital heart defects. We enrolled 7 pediatric patients with complex congenital heart defects in this proof-of-concept study. Preoperative computed tomographic images and intraoperative transesophageal echocardiographic images were acquired for all patients.

ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling.

Signal transducer and activator of transcription 3 (STAT3) is a critical transcriptional factor in a variety of cellular processes, and is frequently over-activated in a range of human tumors. However, the processes that regulate STAT3 activation need to be further clarified. With a yeast two-hybrid screening, we identified enoyl-CoA hydratase short chain 1 (ECHS1) as a novel STAT3 binding protein.

RAD23A negatively regulates RIG-I/MDA5 signaling through promoting TRAF2 polyubiquitination and degradation.

RIG-I/MDA5 plays a pivotal role in innate immunity by detecting intracellular double-stranded RNA (dsRNA) and activating the transcription of type I interferons and proinflammatory factors, but the exactly regulating mechanism of RIG-I/MDA5 signaling remains elusive. In this study, UbL-UBA domain containing protein RAD23A was identified as a negative regulator of RIG-I/MDA5-mediated signaling activation through a small interfering RNA (siRNA)-based screening. Knockdown of RAD23A augmented the expression of RIG-I/MDA5-mediated expression of proinflammatory cytokines and IFN-β whereas ectopic expression of RAD23A showed the converse effect.

Gankyrin promotes breast cancer cell metastasis by regulating Rac1 activity.

Tumor metastasis is responsible for most cancer patients' deaths. Understanding the mechanism of metastasis is crucial for improving the cure rate for cancer. Here, we report that Gankyrin, a chaperone of ubiquitin-proteasome, has an essential role in breast cancer metastasis.

CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling.

Janus kinase 1/signal transducers and activators of transcription 3 (JAK1/STAT3) pathway is one of the recognized oncogenic signaling pathways that frequently overactivated in a variety of human tumors. Despite rapid progress in elucidating the molecular mechanisms of activation of JAK/STAT pathway, the processes that regulate JAK/STAT deactivation need to be further clarified. Here we demonstrate that CUE domain-containing 2 (CUEDC2) inhibits cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity.

[The effects of prolonged sevoflurane anesthesia on renal function in liver fibrosis rabbits].

Objective: To determine the effects of prolonged sevoflurane anesthesia on renal function in liver fibrosis rabbits.

Methods: Fifty male new zealand rabbits were randomly divided into two groups: fibrosis group (n = 40) and normal control group (Group N, n = 10). In the fibrosis group, experimental liver fibrosis was induced by subcutaneous injection of carbon tetrachloride (CCl4 soluted in oil with the concentration of 500 mL/L).

TARDBP gene mutations among Chinese patients with sporadic amyotrophic lateral sclerosis.

Recently, several TARDBP mutations have been identified in sporadic amyotrophic lateral sclerosis (SALS) patients among different ethnicities. Our study aims to analyze the clinical features and mutations in the TARDBP gene among Chinese patients with SALS. One hundred sixty-five patients were studied.

Clinical feature and DYT1 mutation screening in primary dystonia patients from South-West China.

Background: Clinical presentation and DYT1 status amongst Chinese patients with primary dystonia have not been well studied.

Methods: One hundred and twenty patients with primary dystonia from South-West China were studied in a prospective survey for 3.5 years.

GCH1 mutation and clinical study of Chinese patients with dopa-responsive dystonia.

Dopa-responsive dystonia (DRD) is typically caused by heterozygous mutations in GTP cyclohydrolase 1 gene (GCH1). Our aim was to investigate the clinical and genetic features of Chinese DRD patients. We analyzed a cohort of Chinese DRD patients' clinical data.

Clinical and genetic features of patients with sporadic amyotrophic lateral sclerosis in south-west China.

The objective of this study was to analyse clinical and genetic features of patients with sporadic ALS in south-west China. All patients diagnosed with adult-onset sporadic ALS were consecutively followed up, and their clinical characteristics were collected. The frequencies of alleles of six SNPs in the FLJ10986 gene and the association between these SNPs and the clinical features of ALS were analysed.

Transport properties and the large anisotropic magnetoresistance of Cu(x)NbS(2) single crystals.

The transport properties of Cu(x)NbS(2) (x = 0.09, 0.44 and 0.

Anomalous transport properties and phase diagram of the FeAs-based SmFeAsO1-xFx superconductors.

We report the detailed phase diagram and anomalous transport properties of Fe-based high-T_{c} superconductors SmFeAsO1-xFx. It is found that superconductivity emerges at x approximately 0.07, and optimal doping takes place in the x approximately 0.

Giant anisotropy of the magnetoresistance and the 'spin valve' effect in antiferromagnetic Nd(2-x)Ce(x)CuO(4).

We have studied anisotropic magnetoresistance (MR) and magnetization with a rotating magnetic field (B) within the CuO(2) plane in lightly doped AF Nd(2-x)Ce(x)CuO(4). A giant anisotropy in the MR is observed at low temperature, below 5 K. The c-axis resistivity can be tuned over about one order of magnitude just by changing the B direction within the CuO(2) plane, and a scaling behavior for the out-of-plane and in-plane MR is found.

Superconductivity at 43 K in SmFeAsO1-xFx.

Since the discovery of high-transition-temperature (high-T(c)) superconductivity in layered copper oxides, extensive effort has been devoted to exploring the origins of this phenomenon. A T(c) higher than 40 K (about the theoretical maximum predicted from Bardeen-Cooper-Schrieffer theory), however, has been obtained only in the copper oxide superconductors. The highest reported value for non-copper-oxide bulk superconductivity is T(c) = 39 K in MgB(2) (ref.