Publications by authors named "DENNY-BROWN D"

In 1935 two young neurologists, Derek Denny-Brown and E. Graeme Robertson, published an article explaining the mechanisms underlying human defaecation based on a manometric study in patients with sacral root and spinal cord lesions, and normal subjects. This article is still routinely cited in studies of rectal and sphincter ani function.

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The second part of the Bennett Lecture for 1975 by Denny-Brown examined the subcortical representation of the dissociation of function described by Denny-Brown and Chambers. Complete removal in the macaque monkey of the corticomesencephalic fibers where they pass from pulvinar to colliculus, and of the colliculus, resulted in the same loss of visual object identification, binocular fixation, and visuosocial behavior that followed removal of area 17. Vision for peripheral movement and spatial orientation ("panoramic vision") remained excellent, with release of catatonia.

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The first part of the Bennett Lecture for 1975 is a description of the dissociation of visual perception in the macaque monkey by ablation of area 17 on the one hand, and of areas 18 and 19 on the other. Bilateral removal of area 17, with careful preservation of a great part of areas 18 and 19, and of the inferior pulvinar, resulted in loss of binocular fixation, loss of visual recognition of still objects, and loss of visuosocial behavior such as grimacing and vocalization. There remained excellent visuospatial orientation and reaching for moving peripheral visual targets.

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