Publications by authors named "DEGRAND F"
Article Synopsis
- The study tested the effectiveness of cytostatic and anti-inflammatory drugs on a specific immune response in mice, known as cutaneous basophil hypersensitivity (CBH) induced by oxazolone.
- The drugs were administered at various times around sensitization and challenge, revealing that cytostatics primarily work during cell commitment, while corticosteroids target inflammation in that phase, and NSAIDs have variable effects.
- D-Penicillamine and levamisole showed similar suppressive effects in normal animals, indicating that the CBH model is useful for examining drug effects on T-cell related inflammation.
Immunization of the mouse by free mono-ABA-Tyrosine (ABA-Tyr) in complete Freund's adjuvant leads to a specific sensitization. This can be assessed by increase in ear thickness after challenge with ABA-Protein conjugates. The intensity of the skin reaction is directly related to both the antigen dosage and the amount of BCG incorporated in the adjuvant.
View Article and Find Full Text PDFIn the guinea pig, mono-ABA-Tyrosone (ABA-Tyr) has been extensively studied as a hapten capable of inducing delayed type hypersensitivity in the absence of circulating antibodies. This model has been extented to the rat, and cellular sensitivity has been assessed both "in vivo" (skin reaction) and "in vitro" (cellular proliferation and lymphocyte migration inhibition). All the reactions studied follow a reproducible pattern with maximal positivity between 4 and 13 days, and negative responses after 20 days.
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