Effect of chronic administration of magnesium supplement (magnesium glycinate) on male albino wistar rats' intestinal (Ileum) motility, body weight changes, food and water intake.

Recent researches suggests magnesium as an adjuvant medication for COVID 19 patients. Magnesium relaxes skeletal muscles, an effect when prolonged in intestinal smooth muscles can cause severe discomfort such as bloating, vomiting, constipation and nausea. The objectives of this study was to ascertain if magnesium will cause relaxation of the intestinal (ileum) smooth muscles as it does in skeletal muscles.

Cannabis sativa exacerbate testicular function by increased oxidative stress, altered male reproductive hormones, sperm quality/quantity and cellular architecture of the testis.

The illicit use of Cannabis in Nigeria is on the increase within the last 10 years and has been implicated as one of the causes of fertility disorder among young men in Nigeria. Hence, this study aimed to ascertain the reproductive impact of n-hexane extract of Cannabis sativa on male Wistar rats. Fifteen male Wistar rats weighing between 180 and 200 g were assigned into three groups of five animals each.

Inhibition of human androgen receptor by delta 9-tetrahydro-cannabinol and cannabidiol related to reproductive dysfunction: A computational study.

There have been conflicting reports on the impact of Cannabis sativa impact on reproductive function. Hence this study was aimed to ascertain the impact of tetrahydrocannabinol (THC) and cannabidiol (CBD) binding affinity on human androgen receptor (AR) via computational molecular dynamic simulation. The human AR coordinate in this study is derived from human AR in complex with the ligand metribolone (R18) (PBD ID: 1E3G) template using (MODELER version.

Effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters and serum oxidative stress markers in fructose-induced diabetic Wistar rats.

Context: Deleterious effects of diabetes on seminal quality, serum metals and antioxidants have been confirmed.

Objective: This study evaluated the effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters, serum total antioxidant capacity (TAC), nitric oxide (NO), malonyldialdehyde (MDA), calcium and magnesium in fructose-induced diabetic rats.

Materials And Methods: Thirty rats were grouped into non-diabetic controls, diabetic controls, diabetic rats given vitamin E + C, calcium + magnesium and vitamin E + C + calcium + magnesium.

Effect of Vitamin C Supplementation on Platelet Aggregation and Serum Electrolytes Levels in Streptozotocin-Induced Diabetes Mellitus in Rats.

Diabetes mellitus (DM) is a disease condition characterised by hyperglycemia; free radical and abnormalhaematological indices. Vitamin C can reduce free radical generation and ameliorate adverse conditions of diabetes mellitus.The aim of the present study is to investigate the effect of vitamin C on platelet aggregation and electrolyte levels in Type 1DM.

Altered biliary flow rate and bile composition following consumption of ethanolic fruit extract of Dennettia in rats.

Background: Dennettia tripetala is a tropical plant with some ethno-medicinal uses; it enhances uterine contraction/involution in pregnant and post-partum women, it is also a mild laxative, with anti-bacteria, antifungal properties etc..

Aims: This study sought to elucidate the impact of D.

Effect of Gongronema latifolium ethanol leaf extract on gastric acid secretion and cytoprotection in streptozotocin-induced diabetic rats.

Objectives: Gongronema latifolium leaves have been used in folklore medicine to manage diabetes mellitus and alleviate dyspepsia. This study aimed to provide a pharmacological basis to the medicinal use ofGongronema latifolium as an antidiabetic and antiulcerogenic agent in diabetes mellitus.

Methods: Ethanol extract from the leaf (200 mg/kg bodyweight) of Gongronema latifolium was administered to both streptozotocin-induced diabetic and control groups orally for 14 days.

Phytochemistry and some haematological changes following oral administration of ethanolic root extract of Gongronema latifolium in rats.

Gongronema latifolium is a climbing perennial plant that belongs to the family of asclepidaceae. The medicinal uses of the leaves and stem bark extract of Gongronema latifolium has been reported in many scientific literatures to include anti-hyperglycaemic, anti-ulcerative etc. There is paucity in scientific reports on the medicinal properties of the root extract.

Aqueous leaf extract of Rothmannia longiflora improves basal metabolic rate and electrolyte parameters in alloxan-induced diabetic rats.

This study evaluated the action of aqueous leaf extract of Rothmannia longiflora on basal metabolic rate and electrolyte profile of alloxan-induced diabetic rats. Fifteen male Wistar rats weighing 135-140 g were assigned to 3 groups of 5 rats each. Group 1 which served as control received placebo treatment, group 2 namely the diabetic [untreated] group also received placebo treatment whereas group 3-the extract treated diabetic group was administered extract [15 g/kg body weight] by oral administration for 14 days.

Effect of ethanolic extract of Dennettia tripetala fruit on haematological parameters in albino Wistar rats.

The effect of oral administration of ethanolic extract of Dennettia tripetala fruits on haematological parameters in albino Wistar rats was investigated. Lethality studies revealed that the extract had an LD50 value of 251.19mg/kg mice intraperitoneal.