Performance of a vancomycin dosage regimen developed for obese patients.

Purpose: An original and a revised vancomycin dosing protocol for obese patients were compared with respect to attainment of target serum trough vancomycin concentrations and the occurrence of nephrotoxicity.

Methods: The attainment of target vancomycin trough values (10-20 μg/mL) and nephrotoxicity were compared retrospectively between an original protocol (vancomycin 15 mg/kg i.v.

Analgesic efficacy of intranasal butorphanol (Stadol NS) in the treatment of pain after dental impaction surgery.

Purpose: This study evaluated the safety and efficacy of increasing doses of intranasal butorphanol (Stadol NS, Bristol-Myers Squibb, New York, NY) compared with placebo in controlling moderate to severe pain after removal of bony impacted third molars.

Patients And Methods: This single-dose, double-blind, parallel-group, dose-response trial compared the efficacy and safety of 4 doses of intranasally administered butorphanol tartrate and placebo in controlling moderate to severe pain after the removal of impacted third molars in 151 patients. The study was conducted at 2 sites.

Analgesic efficacy and safety of (R)- ketoprofen in postoperative dental pain.

This double-blind, randomized, parallel-group study compared the analgesic efficacy and safety of single doses of (R)- ketoprofen 25 mg and 100 mg to that of acetaminophen 1,000 mg and placebo in 177 patients experiencing moderate to severe pain after surgical removal of their impacted third molars. Both (R)- ketoprofen 100 mg and acetaminophen 1,000 mg were significantly (P < 0.05) more efficacious than placebo for all summary analgesic measures.

Using anesthetic localization to diagnose oral and dental pain.

The anesthetic localization procedure is an aid in ruling out or confirming suspected primary sources of oral or dental pain. The authors present two cases to demonstrate the effectiveness of the procedure.

ICOHR: intelligent computer based oral health record.

The majority of work on computer use in the dental field has focused on non-clinical practice management information needs. Very few computer-based dental information systems provide management support of the clinical care process, particularly with respect to quality management. Traditional quality assurance methods rely on the paper record and provide only retrospective analysis.

Picenadol in a large multicenter dental pain study.

Study Objective: To estimate the analgesic dose of picenadol hydrochloride equal to codeine 60 mg in a dental pain model.

Design: Randomized, double-blind, parallel, dose-response study.

Setting: Four university-based dental clinics.

Relationships between preferred and maximum effort low-back motion.

The purpose of this study was to determine if subjects differed in their preferred and maximum effort low-back-movement characteristics, and to determine if preferred low-back-movement characteristics could contribute to the prediction of maximum effort performance parameters. Sixteen subjects performed a flexibility trial, isometric exertions, and both maximum effort and preferred effort repetitive trunk motion against a resistance set at 50% of the recorded maximum isometric torques. All movement directions about all three primary axes were examined.

Next stop 21st century: a look at the future as an extension of the past.

This comprehensive forecast of the 21st century reinforces the continuing importance of information and its management. Although focused toward association executives, readers should find much of the discussion of particular relevances.