: Co-Design of a Novel Approach for Engaging People with Dementia in Physical Activity.

Background: Promoting physical activity among people living with dementia is critical to maximise physical, cognitive and social benefits; yet the lack of knowledge, skills and confidence among health professionals, informal care partners and people with dementia deters participation. As the initial phase of a larger feasibility study, co-design was employed to develop a new model of community care, to facilitate the physical activity participation of older people living with mild dementia.

Methods: Co-design methodology was utilised with nine stakeholders (with experience in referring to or providing physical activity programs and/or contributing to policy and program planning) over three workshops plus individual interviews with four care partners of people with dementia.

Associations of Physical Activity and Cardiorespiratory Fitness with Incident Chronic Kidney Disease in a Korean Population.

Objective: This large cohort study aimed to examine the overall associations of physical activity (PA) and estimated cardiorespiratory fitness (eCRF) with incident chronic kidney disease (CKD).

Methods: This study included a total of 274,292 participants (mean age, 37.9±8.

Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development.

Cancers with activating mutations of KRAS show a high prevalence but remain intractable, requiring innovative strategies to overcome the poor targetability of KRAS. Here, we report that KRAS expression is post-translationally up-regulated through deubiquitination when the scaffolding function of NDRG3 (N-Myc downstream-regulated gene 3) promotes specific interaction between KRAS and a deubiquitinating enzyme, USP9X. In KRAS-mutant cancer cells KRAS protein expression, downstream signaling, and cell growth are highly dependent on NDRG3.

Supercycle Al-Doped ZnMgO Alloys via Atomic Layer Deposition for Quantum Dot Light-Emitting Diodes.

Colloidal quantum-dot light-emitting diodes (QD-LEDs) have been significantly improved in terms of device performance and lifetime by employing zinc oxide (ZnO) as an electron transport layer (ETL). Although atomic layer deposition (ALD) allows fabrication of uniform, high-quality ZnO films with minimal defects, the high conductivity of ZnO has hindered its straightforward application as an ETL in QD-LEDs. Herein, we propose fabrication of Al-doped ZnMgO (Al:ZnMgO) ETLs for QD-LEDs through a supercycle ALD, with alternating depositions of various metal oxides.

synthesis of semiconductor nanoparticles in for light-driven ammonia production.

Ammonia (NH) is an important commodity chemical used as an agricultural fertilizer and hydrogen-storage material. There has recently been much interest in developing an environmentally benign process for NH synthesis. Here, we report enhanced production of ammonia from diazotrophs under light irradiation using hybrid composites of inorganic nanoparticles (NPs) and bacterial cells.

Strategies for enhancing the implementation of school-based policies or practices targeting diet, physical activity, obesity, tobacco or alcohol use.

Background: A range of school-based interventions are effective in improving student diet and physical activity (e.g. school food policy interventions and classroom physical activity interventions), and reducing obesity, tobacco use and/or alcohol use (e.

Particulate Matter Induces NLRP3 Inflammasome-Mediated Pyroptosis in Human Nasal Epithelial Cells.

Background And Objectives: Air pollution, particularly particulate matter (PM), has a variety of adverse effects on human health. PM is known to induce cell death through various pathways, including pyroptosis. Despite its significance, research on PM-induced pyroptosis in nasal epithelial cells remains limited.

Methodological Issues in Measuring Restrictive Care Practices (Mechanical/physical restraint, Chemical restraint and Seclusion) in Adult Mental Health Inpatient Units: A Systematic Review of Recent Literature.

Aims: To identify and characterise the approaches and instruments used in recent literature to measure the prevalence of restrictive care practices in adult mental health inpatient units. Additionally, it sought to summarise the reported psychometric properties, including reliability and validity of these measures.

Methods: A systematic review of recent litratures was conducted using Scopus, MEDLINE, CINAHL, PsycINFO, Web of Science and Embase databases to identify studies published from 1 January 2010 to 11 October 2023.

Co-Designing Case Scenarios and Survey Strategies to Examine the Classification and Reporting of Restrictive Care Practices in Adult Mental Health Inpatient Settings: Perspectives From International Stakeholders.

There is a global initiative to reduce the use of restrictive care practices in mental health settings. Variations in the reported rates across regions complicate the understanding of their use and tracking trends over time. However, it remains unclear whether these discrepancies reflect real differences in the implementation of these practices or are sourced from inconsistencies in incident classification and reporting methods.

Amino Acid and Glucose Fermentation Maintain ATP Content in Mouse and Human Malignant Glioma Cells.

Energy is necessary for tumor cell viability and growth. Aerobic glucose-driven lactic acid fermentation is a common metabolic phenotype seen in most cancers including malignant gliomas. This metabolic phenotype is linked to abnormalities in mitochondrial structure and function.

Changes in Muscle Mass and Bone Density and Their Relationship After Total Knee Arthroplasty.

To investigate the effects of total knee arthroplasty (TKA) on muscle mass and bone density in end-stage knee osteoarthritis (OA). This prospective study was conducted on 111 patients with Kellgren-Lawrence grade 4 knee OA who underwent TKA after failing to respond to conservative treatment for more than 3 months at a single institution from June 2022 to May 2023. Appendicular lean mass index (ALMI) and bone mineral density (BMD) were measured using dual-energy X-ray absorptiometry before and every 6 months after surgery.

Addressing Selection Biases within Electronic Health Record Data for Estimation of Diabetes Prevalence among New York City Young Adults: A Cross-Sectional Study.

Introduction: There is growing interest in using electronic health records (EHRs) for chronic disease surveillance. However, these data are convenience samples of in-care individuals, which are not representative of target populations for public health surveillance, generally defined, for the relevant period, as resident populations within city, state, or other jurisdictions. We focus on using EHR data for estimation of diabetes prevalence among young adults in New York City, as rising diabetes burden in younger ages call for better surveillance capacity.

Associations between physical activity, long COVID symptom intensity, and perceived health among individuals with long COVID.

Introduction: Physical activity (PA) is associated with better perceived health among individuals with chronic conditions. However, PA's relationship with perceived health in people with long COVID is unclear and may be modified by long COVID symptom burden.

Methods: Participants with self-reported long COVID ( = 379) responded to an online survey cross-sectionally assessing PA levels, perceived physical and mental health, and intensity of CDC-defined long COVID symptoms on a 0-100 scale.

Dementia Rehabilitation Training for General Practitioners and Practice Nurses: Does It Make a Difference?

Background/objectives: Rehabilitation helps reduce disability in dementia. The Australian National Dementia Action Plan identifies a gap in clear treatment pathways post-diagnosis, affecting the quality of life for those with dementia. This study assessed the impact of a one-day dementia training course and follow-up on GPs' and practice nurses' knowledge, attitudes, and confidence regarding dementia rehabilitation.

Selective photocatalytic C-C coupling of benzyl alcohol into hydrobenzoin using Pt-deposited CdS nanosheets passivated with cysteamine.

Achieving high selectivity towards hydrobenzoin (HB) from photocatalytic carbon-carbon (C-C) coupling reaction of benzyl alcohol (BzOH) remains a challenge due to side competing reactions and subsequent conversions of HB into its derivatives. In this study, we have developed a high-performance CdS-based photocatalyst for synthesizing HB with precisely controlled surface properties and structure, achieving high selectivity for HB synthesis. We employed strategies such as cysteamine passivation and Pt deposition to address issues related to photogenerated charge trapping and recombination, thereby enhancing the photocatalytic capability of CdS.

Advanced Vitrimer with Spiropyran Beads: A Multi-Responsive, Shape Memory, Self-Healing, and Reprocessable Smart Material.

Thermosetting materials have limitations in terms of reshaping and recycling due to their irreversible bond structures, leading to significant plastic waste issues. Recently, epoxy vitrimers based on dynamic covalent bond exchange have been introduced as promising alternatives to traditional thermosets. Particularly, they demonstrate significant potential applications in the field of multi-responsive materials.

The Right to Rehabilitation for People With Dementia: A Codesign Approach to Barriers and Solutions.

Introduction: People with dementia of all ages have a human right to equal access to quality health care. Despite evidence regarding its effectiveness, many people living with dementia are unable to access rehabilitation for promoting function and quality of life. Conducted in Australia, this study was designed to (1) explore barriers to access to dementia rehabilitation and (2) identify solutions that improve access to rehabilitation.

Spatial Control of Nickel Vacancies in Colloidal NiMgO Nanocrystals for Efficient and Stable All-inorganic Quantum Dot Light-Emitting Diodes.

Colloidal quantum dot (QD)-based light-emitting diodes (QD-LEDs) have reached the pinnacle of quantum efficiency and are now being actively developed for next-generation displays and brighter light sources. Previous research has suggested utilizing inorganic hole-transport layers (HTLs) to explore brighter and more stable QD-LEDs. However, the performance metrics of such QD-LEDs with inorganic HTLs generally lag behind those of organic-inorganic hybrid QD-LEDs employing organic HTLs.