n-3 polyunsaturated fatty acids raise low-density lipoproteins, high-density lipoprotein 2, and plasminogen-activator inhibitor in healthy young men.

The effects of a moderate supplementation in n-3 polyunsaturated fatty acids (PUFAs) were investigated in 36 young healthy adult males. Factors investigated were lipoprotein (including HDL subfractions and apolipoproteins) and hemostasis indexes, assessed by platelet aggregation and plasminogen-activator-inhibitor (PAI) activity. Fat-controlled diets were prescribed, one with and one without a fish-oil supplement (control diet), successively during 3 wk in random order.

[Effects of dietary omega-6 and omega-3 fatty acids on levels of long chain polyunsaturated fatty acids in erythrocytes].

C18:2 omega 6/C18:3 omega 3 ratio was lowered in the diet of Elderly subjects. This was done by the replacement of usual sunflower oil by rapeseed oil or by supplementing soybean oil. This diet modification induced an increase of EPA (C20:5 omega 3) and DHA (C22:6 omega 3) in red cell phospholipids.

[Mortality and morbidity in a cohort of elderly Parisian managers followed for 14 years].

A randomized sample of 180 male managers, 63-64 years old received a standardized medical examination at the four times of a longitudinal study (1975-78-82-88). The prevalence and incidence rates of principal chronic diseases were evaluated according to ICD-9. The incidence rates of surgery operations and death were calculated.

Inhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid.

Elderly people ingested 150 mg/day of icosapentaenoic acid (20:5n-3) or a placebo for one month. Platelet aggregation, platelet arachidonate metabolism and the fatty acid composition of both plasma and platelet lipids were investigated before and after the intake. Platelet aggregation induced by collagen, epinephrine or low concentrations of ADP was significantly reduced after 20:5n-3 intake.

[Aging of cognitive functions. Results of a longitudinal study].

This study had the two following purposes: to assess the age-related changes in the fluid and crystallized components of intelligence in subjects over age sixty five; to examine whether these age-related changes were linked to any biological, psychological and social factors. The sample was composed of 50 male subjects who were examined three times: in 1968, 1973 and 1977. At the beginning of the study, their age ranged from 60 to 79 years and they were all in good health.

[Retirement, psychological well-being and health: longitudinal study of a population of Parisian executives].

A longitudinal study was carried out on a sample of 155 french male managers in order to test the hypothesis that retirement has negative effects on health and life satisfaction in upper white-collar workers. At wave 1 (in 1976) of the study, these 155 managers were all working full time. At wave 2 (in 1979), 105 were retired and 50 were still working full time.

[Study of the metabolism of fatty acids and total plasma lipids, and platelet aggregation of a population of elderly men using a diet enriched in gamma-linolenic acid].

33 healthy men, 72 years old on average, ingested during five week: 2,4 g of Oenothera Biennis oil rich in PUFA. Before and after ingestion, platelet aggregation was measured according to the Born's photometric method, which divided the original group into two classes: "15" normal subjects (NAG) and "18" hyperagregated (HAG). The fatty acids contained in the serum were analysed by GLC.