Actionable NSCLC Mutation Identification by Comprehensive Genomic Profiling for Clinical Trial Enrollment: The European Program for the Routine Testing of Patients With Advanced Lung Cancer (EPROPA).

Introduction: The advocacy Women Against Lung Cancer in Europe (WALCE) promoted the European Program for the Routine Testing of Patients With Advanced Lung Cancer (EPROPA) and provided a free-of-charge molecular profiling platform for NSCLC sample characterization with the aim of increasing the detection of targetable drivers and improving patients' access to clinical trials in Europe.

Methods: From January 2021 to December 2023, 20 centers located at five different European countries (Greece, Slovenia, Romania, Albania, and Italy) joined EPROPA, with 555 patients with advanced NSCLC registered to the program. Anonymized patients' clinical-pathological data were shared through the EPROPA web platform and tissue samples were collected at the Molecular Pathology Unit of the Reference Center (University of Turin) for molecular analyses.

Psychometric evaluation of a novel tool for assessing gestational diabetes and hypertension care: knowledge, attitudes, and practices of midwives and nurses.

While standardized assessment of knowledge, attitudes, and practices (KAP) related to gestational diabetes and hypertension is possible with a valid tool, existing research remains limited. This prospective validation study aimed to develop and validate a novel tool to assess the KAP of midwives and obstetric nurses. We included 125 midwives and obstetric nurses who routinely care for patients with gestational diabetes and hypertension.

Semi-Analytical Approach and Green's Function Method: A Comparison in the Analysis of the Interaction of a Moving Mass on an Infinite Beam on a Three-Layer Viscoelastic Foundation at the Stability Limit-The Effect of Damping of Foundation Materials.

In this paper, the interaction of a mass moving uniformly on an infinite beam on a three-layer viscoelastic foundation is analyzed with the objective of determining the lowest velocity at the stability limit, called, in this context, the critical velocity. This issue is important for rail transport and, in particular, for the high-speed train, because the moving mass is the basic model of a vehicle, and the infinite beam on a three-layer viscoelastic foundation is the usual mechanical representation of the railway track. In addition to this, the advantages and disadvantages of the two implemented methods, namely, the semi-analytical approach and the Green's function method, are summarized in terms of computational time, the precision of the obtained results, limitations, and the feasibility of implementation.

Death by SARS-CoV 2: a Romanian COVID-19 multi-centre comorbidity study.

Evidence regarding the relation between SARS-CoV-2 mortality and the underlying medical condition is scarce. We conducted an observational, retrospective study based on Romanian official data about location, age, gender and comorbidities for COVID-19 fatalities. Our findings indicate that males, hypertension, diabetes, obesity and chronic kidney disease were most frequent in the COVID-19 fatalities, that the burden of disease was low, and that the prognosis for 1-year survival probability was high in the sample.

HYPOCALCEMIC CARDIOMYOPATHY - A RARE HEART FAILURE ETIOLOGY IN ADULT.

Introduction: Heart failure and dilated cardiomyopathy (DCM) in adults are rarely caused by hypoparathyroidism induced hypocalcemia.

Case Report: Female patient, 40 years old, diabetic, with previous history of thyroidectomy for Graves' disease, was hospitalized for syncope and symptoms of heart failure. ECG revealed sinus tachycardia, long QT, negative T from V1 up to V4.

Hyperelastic Tuning of One-Dimensional Phononic Band Gaps Using Directional Stress.

In this paper, we show that acoustoelasticity in hyperelastic materials can be understood using the framework of nonlinear wave mixing, which, when coupled with an induced static stress, leads to a change in the phase velocity of the propagating wave with no change in frequency. By performing Floquet wave eigenvalue analysis, we also show that band gaps for periodic composites, acting as 1-D phononic crystals, can be tuned using this static stress. In the presence of second-order elastic nonlinearities, the phase velocity of propagating waves in the phononic structure changes, leading to observable shifts in the band gaps.

Electronic structure and nesting-driven enhancement of the RKKY interaction at the magnetic ordering propagation vector in Gd2PdSi3 and Tb2PdSi3.

Measurements of the low-energy electronic structure in Gd2PdSi3 and Tb2PdSi3 by means of angle-resolved photoelectron spectroscopy reveal a Fermi surface consisting of an electron barrel at the Gamma point surrounded by spindle-shaped electron pockets originating from the same band. The calculated momentum-dependent RKKY coupling strength is peaked at the 1/2GammaK wave vector, which coincides with the propagation vector of the low-temperature in-plane magnetic order observed by neutron diffraction, thereby demonstrating the decisive role of the Fermi surface geometry in explaining the complex magnetic ground state of ternary rare earth silicides.

Stable spatiotemporal solitons in bessel optical lattices.

We investigate the existence and stability of three-dimensional solitons supported by cylindrical Bessel lattices in self-focusing media. If the lattice strength exceeds a threshold value, we show numerically, and using the variational approximation, that the solitons are stable within one or two intervals of values of their norm. In the latter case, the Hamiltonian versus norm diagram has a swallowtail shape with three cuspidal points.

Three-dimensional walking spatiotemporal solitons in quadratic media.

Two-parameter families of chirped stationary three-dimensional spatiotemporal solitons in dispersive quadratically nonlinear optical media featuring type-I second-harmonic generation are constructed in the presence of temporal walk-off. Basic features of these walking spatiotemporal solitons, including their dynamical stability, are investigated in the general case of unequal group-velocity dispersions at the fundamental and second-harmonic frequencies. In the cases when the solitons are unstable, the growth rate of a dominant perturbation eigenmode is found as a function of the soliton wave number shift.

Azimuthal instability of spinning spatiotemporal solitons.

We find one-parameter families of three-dimensional spatiotemporal bright vortex solitons (doughnuts, or spinning light bullets), in dispersive quadratically nonlinear media. We show that they are subject to a strong instability against azimuthal perturbations, similarly to the previously studied (2+1)-dimensional bright spatial vortex solitons. The instability breaks the spinning soliton into several fragments, each being a stable nonspinning light bullet.

Stable solitons of quadratic ginzburg-landau equations.

We present a physical model based on coupled Ginzburg-Landau equations that supports stable temporal solitary-wave pulses. The system consists of two parallel-coupled cores, one having a quadratic nonlinearity, the other one being effectively linear. The former core is active, with bandwidth-limited amplification built into it, while the latter core has only losses.

Three-dimensional spinning solitons in the cubic-quintic nonlinear medium.

We find one-parameter families of three-dimensional spatiotemporal bright vortex solitons (doughnuts, or spinning light bullets), in bulk dispersive cubic-quintic optically nonlinear media. The spinning solitons display a symmetry-breaking azimuthal instability, which leads to breakup of the spinning soliton into a set of fragments, each being a stable nonspinning light bullet. However, in some cases the instability is developing so slowly that the spinning light bullets may be regarded as virtually stable ones, from the standpoint of an experiment with finite-size samples.