Interlayer manipulation of bio-inspired TiCT nanocontainer through intercalation of amino acid molecules to dramatically boosting uranyl hijacking capability from seawater.

More than 4.5 billion tons of unconventional uranium resources [UO(CO)] are uniformly dissolved in seawater, providing a sustainable and abundant fuel source for the development of nuclear energy. Herein, we presented a rational design and development of TiCT nanocontainer inspired by the exceptional selectivity and affinity exhibited by superb-uranyl proteins through amino acid intercalation.

Indomethacin and 20-hydroxyecdysone influence protein expression in a Spodoptera frugiperda nervous system cell line.

Insecticide mode of action studies provide insights into how new insecticidal actives function and contribute to assessing safety to humans and nontarget organisms. Insect cell lines that express potential target sites can serve as valuable tools in this effort. In this paper, we report on the influence of two signaling molecules on protein expression in a nervous system cell line established from Spodoptera frugiperda (Bayer/BCIRL-SfNS2-0714-TR).

Cognitive and language outcomes for pediatric hearing loss with otologic surgery.

Objectives: To test the hypothesis that surgical otologic intervention for any type of pediatric hearing loss decreases the odds for incident adverse cognitive and linguistic developmental outcomes.

Study Design: Retrospective cohort database study.

Methods: Electronic medical record data from the TriNetX Research Network were queried for children with congenital, sensorineural, conductive, and mixed hearing loss (HL) between ages 0 and 5 years.

Association of Smoke and Nicotine Product Consumption With Sensorineural Hearing Loss: A Population-Level Analysis.

Objective: To test the hypothesis that use of cigarettes or other products with either cigarette-like smoke profile or high nicotine content by young populations increases the odds of developing sensorineural hearing loss (SNHL).

Study Design: Retrospective cohort study.

Setting: TriNetX US Collaborative Network (2003-2022).

A robust local pulse wave imaging method based on digital image processing techniques.

The original diameter velocity loop method (ln(D)U-loop) cannot accurately extract the blood vessel diameter waveform when the quality of ultrasound image data is not high (such as obesity, age, and the operation of the ultrasound doctor), so it is unable to measure the pulse wave velocity (PWV) of the ascending aorta. This study proposes a diameter waveform extraction method combining threshold, gradient filtering, and the center of gravity method. At the same time, the linear regression method of searching for the rising point of the systolic period is replaced by the optimal average of two linear regression methods.

High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells.

Endoglin (ENG) is a single-pass transmembrane protein highly expressed on vascular endothelial cells, although low expression levels can be detected in many other cell types. Its extracellular domain can be found in circulation known as soluble endoglin (sENG). Levels of sENG are elevated in many pathological conditions, in particular preeclampsia.

Do green innovation, I.C.T., and economic complexity matter for sustainable development of B.R.I. economies: moderating role of higher education.

The research intends to enlarge the environmental economics literature by displaying the probable mechanisms between green innovation, higher education, and sustainable development. In the context of a new era, sustainability faces challenging obstacles. Many studies have looked at fundamental factors affecting CO emissions, while the impact of green innovation and higher education is essential but mostly ignored.

Blow-up and boundedness in quasilinear attraction-repulsion systems with nonlinear signal production.

In this paper, we consider the quasilinear parabolic-elliptic-elliptic attraction-repulsion system $ \begin{equation} \nonumber \left\{ \begin{split} &u_t = \nabla\cdot(D(u)\nabla u)-\chi\nabla\cdot(u\nabla v)+\xi\nabla\cdot(u\nabla w),&\qquad &x\in\Omega,\,t>0, \\ & 0 = \Delta v-\mu_{1}(t)+f_{1}(u),&\qquad &x\in\Omega,\,t>0, \\ &0 = \Delta w-\mu_{2}(t)+f_{2}(u),&\qquad &x\in\Omega,\,t>0 \end{split} \right. \end{equation} $ under homogeneous Neumann boundary conditions in a smooth bounded domain $ \Omega\subset\mathbb{R}^n, \ n\geq2 $. The nonlinear diffusivity $ D $ and nonlinear signal productions $ f_{1}, f_{2} $ are supposed to extend the prototypes $ \begin{equation} \nonumber D(s) = (1+s)^{m-1},\ f_{1}(s) = (1+s)^{\gamma_{1}},\ f_{2}(s) = (1+s)^{\gamma_{2}},\ s\geq0,\gamma_{1},\gamma_{2}>0,m\in\mathbb{R}.

Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4/NF-κB signaling pathway.

Qingrequzhuo capsule (QRQZ), composed of Morus alba L., Coptis chinensis Franch., Anemarrhena asphodeloides Bunge, Alisma plantago-aquatica subsp.

Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibroinflammatory stroma and often experiences conditions of insufficient oxygen availability or hypoxia. Cancer-associated fibroblasts (CAF) are a predominant and heterogeneous population of stromal cells within the pancreatic tumor microenvironment. Here, we uncover a previously unrecognized role for hypoxia in driving an inflammatory phenotype in PDAC CAFs.

Effects of acetate, propionate, and pH on volatile fatty acid thermodynamics in continuous cultures of ruminal contents.

To investigate the effects of acetate, propionate, and pH on thermodynamics of volatile fatty acids (VFA) in the rumen, a dual-flow continuous culture study was conducted to quantify production of major VFA, interconversions among the VFA, and H and CH emissions in a 4 × 4 Latin square design. The 4 treatments were (1) control: pH buffered to an average of 6.75; (2) control plus 20 mmol/d of infused acetate (InfAc); (3) control plus 7 mmol/d of infused propionate (InfPr); and (4) a 0.

Extraction of Uranium in Nitric Media with Novel Asymmetric Tetra-Alkylcarbamide.

The use of tetra-alkylcarbamides as novel ligands: N,N-butyl-N',N'-hexylurea (), and N,N-butyl-N',N'-pentylurea (), for the solvent extraction and complexation behaviors of uranium(VI) was synthesized and investigated in this study. The effects of HNO and NO concentrations in the aqueous phase on the distribution ratio of U(VI) were examined. Under 5 mol/L HNO concentration, reached 5.

Investigation of Serum and Macular Carotenoids in Central Serous Chorioretinopathy.

Purpose: This study aimed to evaluate serum lutein and zeaxanthin levels and macular pigment optical density (MPOD) in central serous chorioretinopathy (CSC).

Methods: Fifty-four patients with acute CSC (28-56 years old; 44 men and 10 women) and 62 matched controls were enrolled. Serum lutein and zeaxanthin were measured using the high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method.

An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates.

The SARS-CoV-2 pandemic has affected more than 185 million people worldwide resulting in over 4 million deaths. To contain the pandemic, there is a continued need for safe vaccines that provide durable protection at low and scalable doses and can be deployed easily. Here, AAVCOVID-1, an adeno-associated viral (AAV), spike-gene-based vaccine candidate demonstrates potent immunogenicity in mouse and non-human primates following a single injection and confers complete protection from SARS-CoV-2 challenge in macaques.

Analysis of Host Jejunum Transcriptome and Associated Microbial Community Structure Variation in Young Calves with Feed-Induced Acidosis.

Diet-induced acidosis imposes a health risk to young calves. In this study, we aimed to investigate the host jejunum transcriptome changes, along with its microbial community variations, using our established model of feed-induced ruminal acidosis in young calves. Eight bull calves were randomly assigned to two diet treatments beginning at birth (a starch-rich diet, Aci; a control diet, Con).

3-D Res-CapsNet convolutional neural network on automated breast ultrasound tumor diagnosis.

Purpose: We propose a 3-D tumor computer-aided diagnosis (CADx) system with U-net and a residual-capsule neural network (Res-CapsNet) for ABUS images and provide a reference for early tumor diagnosis, especially non-mass lesions.

Methods: A total of 396 patients with 444 tumors (226 malignant and 218 benign) were retrospectively enrolled from Sun Yat-sen University Cancer Center. In our CADx, preprocessing was performed first to crop and resize the tumor volumes of interest (VOIs).

Investigating the complex interplay between genotype and high-fat-diet feeding in the lactating mammary gland using the and knockout models.

Obesity is a prevailing problem across the globe. Women who are obese have difficulty initiating and sustaining lactation. However, the impact of genetics and diet on breastfeeding outcomes is understudied.

Oxidation of energy substrates in tissues of largemouth bass (Micropterus salmoides).

This study tested the hypothesis that amino acids are oxidized at higher rates than glucose and palmitate for ATP production in tissues of largemouth bass (LMB, a carnivorous fish). Slices (10 to 50 mg) of liver, proximal intestine, kidney, and skeletal muscle isolated from LMB were incubated at 26 °C for 2 h in oxygenated Krebs-Henseleit bicarbonate buffer (pH 7.4, with 5 mM D-glucose) containing either D-[U-C]glucose, 2 mM L-alanine plus L-[U-C]alanine, 2 mM L-aspartate plus L-[U-C]aspartate, 2 mM L-glutamate plus L-[U-C]glutamate, 2 mM L-glutamine plus L-[U-C]glutamine, 2 mM L-leucine plus L-[U-C]leucine, or 2 mM palmitate plus [U-C]palmitate.

The Uptake of Hazardous Metal Ions into a High-Nuclearity Cluster-Based Compound with Structural Transformation and Proton Conduction.

The discovery of novel high-nuclearity oxo-clusters considerably promotes the development of cluster science. We report a high-nuclearity oxo-cluster-based compound with acid/alkali-resistance and radiation stabilities, namely, (HO)[CdSbO(l-tta)(l-Htta)(HO)]·29HO (FJSM-CA; l-Htta = l-tartaric acid), which features a two-dimensionally anionic layer based on the largest Sb-oxo-clusters with 28-metal-ion-core [CdSbO]. It is challenging to efficiently capture Sr, Ba (analogue of Ra), and [UO] ions from aqueous solutions due to their high water solubility and environmental mobility, while it is unprecedented that a novel Sb-oxo-cluster-based framework material FJSM-CA can efficiently remove these hazardous ions accompanied with intriguing structural transformations.

DeepVolume: Brain Structure and Spatial Connection-Aware Network for Brain MRI Super-Resolution.

Thin-section magnetic resonance imaging (MRI) can provide higher resolution anatomical structures and more precise clinical information than thick-section images. However, thin-section MRI is not always available due to the imaging cost issue. In multicenter retrospective studies, a large number of data are often in thick-section manner with different section thickness.

Interethnic scaling of fraction unbound of a drug in plasma and volume of distribution: an analysis of extrapolation from Caucasians to Chinese.

Purpose: Prospective prediction of pharmacokinetic properties for individuals of different ethnic groups could provide useful information for the design of multiregional clinical trials. The accuracy of interethnic scaling of fraction unbound (f) of a drug could determine in large part the predictive capability of volume of distribution as well as renal clearance. As such, exploring the interethnic extrapolation of f from healthy Caucasian to Chinese subjects and associated effect on the scaling of volume of distribution is highly warranted.

Efficient Removal of [UO], Cs, and Sr Ions by Radiation-Resistant Gallium Thioantimonates.

Unconventional ion exchangers can achieve efficient removal of [UO], Cs, and Sr ions from complex aqueous solutions and are of great interest for environmental remediation. We report two new gallium thioantimonates, [MeNH][GaSbS]·HO (FJSM-GAS-1) and [EtNH][GaSbS]·HO (FJSM-GAS-2), which present excellent ion exchange properties for [UO], Cs, and Sr ions. They exhibit high ion exchange capacities for [UO], Cs, and Sr ions ( q = 196 mg/g, q = 164 mg/g, and q = 80 mg/g for FJSM-GAS-1, q = 144 mg/g for FJSM-GAS-2) and short equilibrium times for [UO] ion exchange (5 min for FJSM-GAS-1 and 15 min for FJSM-GAS-2, respectively).

Impact of the Choice of Risk Model for Identifying Low-risk Patients Using the 2014 American College of Cardiology/American Heart Association Perioperative Guidelines.

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: The 2014 American College of Cardiology Perioperative Guideline recommends risk stratifying patients scheduled to undergo noncardiac surgery using either: (1) the Revised Cardiac Index; (2) the American College of Surgeons National Surgical Quality Improvement Program Surgical Risk Calculator; or (3) the Myocardial Infarction or Cardiac Arrest calculator. The aim of this study is to determine how often these three risk-prediction tools agree on the classification of patients as low risk (less than 1%) of major adverse cardiac event.

Methods: This is a retrospective observational study using a sample of 10,000 patient records.

Amino acids are major energy substrates for tissues of hybrid striped bass and zebrafish.

Fish generally have much higher requirements for dietary protein than mammals, and this long-standing puzzle remains unsolved. The present study was conducted with zebrafish (omnivores) and hybrid striped bass (HSB, carnivores) to test the hypothesis that AAs are oxidized at a higher rate than carbohydrates (e.g.

Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.

Organic anion-transporting polypeptide (OATP) 1A2 has the potential to be a target for central nervous system drug delivery due to its luminal localization at the human blood-brain barrier and broad substrate specificity. We found OATP1A2 mRNA expression in the human brain to be comparable to breast cancer resistance protein and OATP2B1 and much higher than P-glycoprotein (P-gp), and confirmed greater expression in the brain relative to other tissues. The goal of this study was to establish a model system to explore OATP1A2-mediated transcellular transport of substrate drugs and the interplay with P-gp.