Background Context: Low back pain (LBP) is a pervasive issue, causing substantial economic burden and physical distress worldwide. Facet joint osteoarthritis (FJ OA) is believed to be a significant contributor to this problem. However, the precise role of chondrocyte senescence in FJ OA remains unclear, as does whether the clearance of chondrocyte senescence can alleviate the progression of FJ OA.
View Article and Find Full Text PDFCellular senescence is an established driver of aging, exhibiting context-dependent phenotypes across multiple biological length-scales. Despite its mechanistic importance, profiling senescence within cell populations is challenging. This is in part due to the limitations of current biomarkers to robustly identify senescent cells across biological settings, and the heterogeneous, non-binary phenotypes exhibited by senescent cells.
View Article and Find Full Text PDFBackground: Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. Whether very early blood-pressure control in the ambulance improves outcomes among patients with undifferentiated acute stroke is uncertain.
Methods: We randomly assigned patients with suspected acute stroke that caused a motor deficit and with elevated systolic blood pressure (≥150 mm Hg), who were assessed in the ambulance within 2 hours after the onset of symptoms, to receive immediate treatment to lower the systolic blood pressure (target range, 130 to 140 mm Hg) (intervention group) or usual blood-pressure management (usual-care group).
Objective: Dasatinib and quercetin (D & Q) have demonstrated promise in improving aged-related pathophysiological dysfunctions in humans and mice. Herein we aimed to ascertain whether the heat stress (HS)-induced cognitive deficits in aged or even young adult male mice can be reduced by D & Q therapy.
Methods: Before the onset of HS, animals were pre-treated with D & Q or placebo for 3 consecutive days every 2 weeks over a 10-week period.
Peripheral blood is gaining prominence as a noninvasive alternative to tissue biopsy to develop biomarkers for glioblastoma (GBM); however, widely utilized blood-based biomarkers in clinical settings have not yet been identified due to the lack of a robust detection approach. Here, we describe the application of globin reduction in RNA sequencing of whole blood (i.e.
View Article and Find Full Text PDFIntroduction: The aim of this study was to develop a novel artificial intelligence (AI) system that can automatically detect and classify protruded gastric lesions and help address the challenges of diagnostic accuracy and inter-reader variability encountered in routine diagnostic workflow.
Methods: We analyzed data from 1,366 participants who underwent gastroscopy at Jiangsu Provincial People's Hospital and Yangzhou First People's Hospital between December 2010 and December 2020. These patients were diagnosed with submucosal tumors (SMTs) including gastric stromal tumors (GISTs), gastric leiomyomas (GILs), and gastric ectopic pancreas (GEP).
Background: Genu varus (GV) is a common deformity characterized by leg bending, which seriously threatens human health. At present, there is no definite conclusion to explain the cause of genu varus. The purpose of this study is to systematically review and meta-analysis the effectiveness and scientific basis of the clinical efficacy of customized orthopedic insoles on genu varus and hope to provide a reference for future research in this field.
View Article and Find Full Text PDFThe conventional direct torque control (DTC) has high torque and stator flux fluctuation that causes the stator current distortion. This paper presents an efficient control method based on the feedback-linearization direct torque control (FL-DTC) method for an interior permanent magnet synchronous motor (IPMSM) drive by using an improved firefly algorithm. The proposed approach can greatly restrain the poor performance of torque and stator flux.
View Article and Find Full Text PDFClin Transl Gastroenterol
June 2022
Introduction: The aim of this study was to assess the feasibility of cross-sectional imaging for detection of pancreatic cancer (PDAC) in patients with new-onset hyperglycemia and diabetes (NOD).
Methods: We conducted a prospective pilot study from November 2018 to March 2020 within an integrated health system. Patients aged 50-85 years with newly elevated glycemic parameters without a history of diabetes were invited to complete a 3-phase contrast-enhanced computed tomography pancreas protocol scan while participating in the Prospective Study to Establish a NOD Cohort.
In this work, the g factors, d-d transition band, local distortion, and their concentration dependences for impurity V in 20Li O-20PbO-45B O -(15 - x)P O :V O (0 ≤ x ≤ 2.5 mol%) glasses are theoretically investigated by using perturbation formulas of g factors for a tetragonally compressed octahedral 3d cluster. In the light of the cubic polynomial concentration functions for cubic field parameter D , covalency factor N, and relative tetragonal compression ratio ρ, the calculated concentration dependences of d-d transition band and g factors for V show good agreement with the experimental data.
View Article and Find Full Text PDFMn-activated oxide-fluoride phosphors are attractive for application in a wide range of solid-state lighting devices because of their distinct red emission at about 630 nm and the abundant storage of Mn ions. However, the zero-phonon line (ZPL) of Mn ions is too weak to be detected in most host materials due to the magnetic dipole nature. In this article, we introduce a co-precipitation method for synthesizing a Mn-doped oxyfluoride perovskite KNaMoOF phosphor containing [MoOF] building units.
View Article and Find Full Text PDFThe local structure, d-d transition band, and spin Hamiltonian parameters (SHPs) are theoretically studied for the V probe in Na O-PbO-Bi O -SiO (NPBS) glass ceramics containing V O dopant with various concentration x (0 ≤ x ≤ 5 mol%) by using the perturbation formulas of the SHPs for tetragonally compressed octahedral 3d clusters. The first decreasing (or increasing) and then increasing (or decreasing) d-d transition band (= 10 D ) and hyperfine structure constants A and A (or g factors g and g ) with x can be suitably simulated with the similarly varying Fourier type concentration functions of cubic field parameter D , covalence factor N, core polarization constant κ, and reduction factor H (or relative tetragonal compression ratio ρ), with the minima (or maxima) at the middle concentration x = 3 mol%, respectively. The above concentration variations of SHPs and the related quantities may originate from the modifications of local crystal field strength, tetragonal compression, and electron cloud distribution near the impurity V with x, corresponding to the highest [V ]/[V ] ratio at 3 mol%.
View Article and Find Full Text PDFBackground: In patients with complex congenital heart disease, such as those with tetralogy of Fallot, the right ventricle (RV) is subject to pressure overload stress, leading to RV hypertrophy and eventually RV failure. The role of lipid peroxidation, a potent form of oxidative stress, in mediating RV hypertrophy and failure in congenital heart disease is unknown.
Methods: Lipid peroxidation and mitochondrial function and structure were assessed in right ventricle (RV) myocardium collected from patients with RV hypertrophy with normal RV systolic function (RV fractional area change, 47.
Purpose: To design a computational method for automatic brain glioma segmentation of multimodal MRI scans with high efficiency and accuracy.
Materials And Methods: The 2018 Multimodal Brain Tumor Segmentation Challenge (BraTS) dataset was used in this study, consisting of routine clinically acquired preoperative multimodal MRI scans. Three subregions of glioma-the necrotic and nonenhancing tumor core, the peritumoral edema, and the contrast-enhancing tumor-were manually labeled by experienced radiologists.
CAR-T (chimeric antigen receptor T cells) immunotherapy is effective in many hematological cancers; however, efficacy in solid tumors is disappointing. Doublecortin-like kinase 1 (DCLK1) labels tumor stem cells (TSCs) in genetic mouse models of colorectal cancer (CRC). Here, we describe a novel CAR-T targeting DCLK1 (CBT-511; with our proprietary DCLK1 single-chain antibody variable fragment) as a treatment strategy to eradicate CRC TSCs.
View Article and Find Full Text PDFStator/rotor winding faults are the common faults in squirrel-cage induction motor systems, which motivates the study of incipient fault detection and isolation (IFDI) to improve the safety and reliability of CRH (China Railway High-speed) trains. In this paper, a dynamic model for squirrel caged induction motor in d-q coordinate system is established firstly, further, the models and characteristics of incipient broken-rotor-bar fault and turn-to-turn short fault are analyzed. After that, a novel robust diagnosis design is proposed for the possible incipient stator/rotor winding faults.
View Article and Find Full Text PDFArch Oral Biol
November 2018
Objective: The aim of this study is to elucidate the local effects of fibroblast growth factor 23 (FGF23) in on mandibular condylar growth in growing rats.
Design: Growing Sprague-Dawley rats received intra-temporomandibular joint injections of phosphate buffer solution (PBS), adenovirus-mediated green fluorescent protein (Ad-GFP) or adenovirus-mediated fibroblast growth factor 23 (Ad-FGF23), which were marked as groups A, B, and C, respectively. In vitro, we treated rat mandibular cartilage chondrocytes with PBS, Ad-GFP, and Ad-FGF23.
Abdominal pain and abnormal bowel habits represent major symptoms for irritable bowel syndrome (IBS) patients that are not adequately managed. Although the etiology of IBS is not completely understood, many of the functions of the gastrointestinal (GI) tract are regulated by the enteric nervous system (ENS). Inflammation or stress-induced expression of growth factors or cytokines may lead to hyperinnervation of visceral afferent neurons in GI tract and contribute to the pathophysiology of IBS.
View Article and Find Full Text PDFThe clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 system has emerged as a powerful tool for knock-in of DNA fragments via donor plasmid and homology-independent DNA repair mechanism; however, conventional integration includes unnecessary plasmid backbone and may result in the unfaithful expression of the modified endogenous genes. Here, we report an efficient and precise CRISPR/Cas9-mediated integration strategy using a donor plasmid that harbors 2 of the same cleavage sites that flank the cassette at both sides. After the delivery of donor plasmid, together with Cas9 mRNA and guide RNA, into cells or fertilized eggs, concurrent cleavages at both sides of the exogenous cassette and the desired chromosomal site result in precise targeted integration without plasmid backbone.
View Article and Find Full Text PDFAJNR Am J Neuroradiol
November 2017
Background And Purpose: Brain temperature is critical for homeostasis, relating intimately to cerebral perfusion and metabolism. Cerebral thermometry is historically challenged by the cost and invasiveness of clinical and laboratory methodologies. We propose the use of noninvasive MR thermometry in patients with cerebrovascular disease, hypothesizing the presence of a measurable brain thermal response reflecting the tissue hemodynamic state.
View Article and Find Full Text PDFThe copper electron paramagnetic resonance gyromagnetic factors are theoretically studied for three novel Cu coordination polymers [Cu(XL)(NO ) ] (1), {[Cu(XL)(4,4'-bpy)(NO ) ]•CH CN} (1a) and {[Cu(XL) ](NO ) •3.5H O} (2) with bi-triazole ligand (XL) = N,N'-bicyclo[2.2.
View Article and Find Full Text PDFTo investigate the effects of nimotuzumab on radiosensitivity of ECA-109 and TE-13 esophageal carcinoma cell lines and explore its possible mechanism. The ECA-109 and TE-13 cells were divided into control group, irradiation group, medicine group, and combined group (irradiation + medicine). In the combined group, ECA-109 and TE-13 cells were treated with nimotuzumab for 24 h before irradiation, and the cells were collected 2 h after irradiation.
View Article and Find Full Text PDFBackground And Purpose: Measuring cerebrovascular reactivity with the use of vasodilatory stimuli, such as acetazolamide, is useful for chronic cerebrovascular steno-occlusive disease. The purpose of this study was to evaluate the effects of acetazolamide on the assessment of hemodynamic impairment and functional connectivity by using noninvasive resting-state blood oxygen level-dependent MR imaging.
Materials And Methods: A 20-minute resting-state blood oxygen level-dependent MR imaging scan was acquired with infusion of acetazolamide starting at 5 minutes after scan initiation.
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a powerful platform for uncovering disease mechanisms and assessing drugs for efficacy/toxicity. However, the accuracy with which hiPSC-CMs recapitulate the contractile and remodeling signaling of adult cardiomyocytes is not fully known. We used β-adrenergic receptor (β-AR) signaling as a prototype to determine the evolution of signaling component expression and function during hiPSC-CM maturation.
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