Publications by authors named "D van Rooyen"
Article Synopsis
- Primary aldosteronism is a condition marked by excessive aldosterone production due to adrenal gland lesions, primarily characterized by disrupted regulation of aldosterone synthase (CYP11B2).
- In a study of aldosterone-producing adenomas (APAs) without known mutations, researchers discovered specific mutations in the gene for mucolipin-3 (TRPML3) associated with increased calcium activity and aldosterone production.
- These findings suggest that mutations in TRPML3 may contribute to hormone excess in primary aldosteronism, highlighting the disease's underlying genetic factors and their impact on hypertension.
Background: Although Objective Structured Clinical Examinations (OSCEs) offer innovative, objective, and fair methods of clinical assessment, their quality is compromised by poor planning and design.
Aim: This study aimed to describe the development and present evidence-based recommendations on strengthening the planning and design of OSCEs for a South African public College of Nursing.
Setting: A South African public College of Nursing.
The classical androgens, testosterone and dihydrotestosterone, together with dehydroepiandrosterone, the precusrsor to all androgens, are generally included in diagnostic steroid evaluations of androgen excess and deficiency disorders and monitored in androgen replacement and androgen suppressive therapies. The C11-oxy androgens also contribute to androgen excess disorders and are still often excluded from clinical and research-based steroids analysis. The contribution of the C11-oxy androgens to the androgen pool has not been considered in androgen deficiency.
View Article and Find Full Text PDFObjective: Explore health professionals' perceptions toward how to address malnutrition within the first 1,000 days of life in underresourced communities.
Design: A qualitative explorative-descriptive study using 8 face-to-face focus group discussions.
Setting: Health facilities serving underresourced communities within Nelson Mandela Bay, Eastern Cape Province, South Africa.
Hyperaldosteronism is often associated with inappropriate aldosterone production and aldosterone synthase (Cyp11b2) expression. Normally, Cyp11b2 expression is limited to the adrenal zona glomerulosa (ZG) and regulated by angiotensin II which signals through Gq protein-coupled receptors. As cells migrate inwards, they differentiate into 11β-hydroxylase-expressing zona fasciculata (ZF) cells lacking Cyp11b2.
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