White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group.

White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies, the generalizability of OCD classification based on diffusion white matter estimates remains unclear. Here, we tested classification accuracy using the largest OCD DTI dataset to date, involving 1336 adult participants (690 OCD patients and 646 healthy controls) and 317 pediatric participants (175 OCD patients and 142 healthy controls) from 18 international sites within the ENIGMA OCD Working Group.

Estimation of Distribution Algorithm for Grammar-Guided Genetic Programming.

Genetic variation operators in grammar-guided genetic programming are fundamental to guide the evolutionary process in search and optimization problems. However, they show some limitations, mainly derived from an unbalanced exploration and local-search trade-off. This paper presents an estimation of distribution algorithm for grammar-guided genetic programming to overcome this difficulty and thus increase the performance of the evolutionary algorithm.

Towards the portability of knowledge in reinforcement learning-based systems for automatic drone navigation.

In the field of artificial intelligence (AI) one of the main challenges today is to make the knowledge acquired when performing a certain task in a given scenario applicable to similar yet different tasks to be performed with a certain degree of precision in other environments. This idea of knowledge portability is of great use in Cyber-Physical Systems (CPS) that face important challenges in terms of reliability and autonomy. This article presents a CPS where unmanned vehicles (drones) are equipped with a reinforcement learning system so they may automatically learn to perform various navigation tasks in environments with physical obstacles.

Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium.

Background: Widely used psychotropic medications for obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs.