Publications by authors named "D Zander-Fox"
Article Synopsis
- Parental exposure to synthetic chemicals before conception can significantly impact fertility and reproductive health, necessitating evaluation of these substances in various biological fluids.
- A new LC-MS/MS method was developed to detect 95 types of xenobiotics in urine, serum, and reproductive fluids, demonstrating high extraction recovery rates and sensitivity.
- Analysis of a cohort of Australian couples undergoing fertility treatment revealed widespread detection of harmful chemicals, such as PFAS and parabens, suggesting potential risks to fertility and indicating the need for further investigation into their effects on reproductive outcomes.
Research Question: Can the addition of progesterone and neurotensin, molecular agents found in the female reproductive tract, after sperm washing increase the fertilization potential of human spermatozoa?
Design: (i) Cohort study of 24 men. Spermatozoa selected by swim-up were incubated in either progesterone or neurotensin (0.1-100 µM) for 1-4 h, and hyperactive motility and binding to hyaluronan (0.
Research Question: What happens to eggs after egg freezing?
Design: A retrospective cohort study was performed spanning 2012-2022. Data were obtained from seven assisted reproductive technology clinics in Victoria, Australia. Aggregated, de-identified data were collected on cycles that resulted in egg freezing and the following outcomes, including treatment involving thawed eggs and disposition outcomes of surplus eggs.
Objective: To investigate whether PIEZO-intracytoplasmic sperm injection (PIEZO-ICSI) increases the fertilization rate, decreases the degeneration rate, and increases the utilization rate per oocyte injected compared with conventional intracytoplasmic sperm injection (ICSI).
Design: Sibling oocyte split multicenter trial.
Setting: Fertility clinics.