Basic Science and Pathogenesis.

Background: Alzheimer's Disease (AD) risk variants APOE4 and TREM2-R47H have been shown to impact glial cell functions and transcriptional profiles. We hypothesize that TREM2-APOE may have synergistic effects in driving pathogenesis and disease progression of AD in a cell type-specific manner.

Methods: We investigated cell-type specific transcriptional changes associated with APOE4- and TREM2-R47H-carrier status.

Multitaper Spectrum Analysis of Consonants Produced by Patients With Dentofacial Disharmonies.

Purpose: This study investigates differences in American English consonants produced by patients who present with various dentofacial disharmonies (DFDs), including severe overbites (Class II), underbites (Class III), and anterior open bites. Previous studies have found that patients with these malocclusion types all produce lingual sibilants and plosives with increased spectral center of gravity and increased spectral variance relative to controls. This result is puzzling since some DFD groups differ from controls in opposite ways, and it is also difficult to interpret because spectral moment measures are affected by a wide range of speech and nonspeech factors.

DENTOFACIAL DISHARMONY PATIENTS' SIBILANTS DIFFER FROM CONTROLS' MORE IN SOURCE THAN FILTER PROPERTIES.

This study uses multitaper spectral analysis to examine the differences in consonants produced by patients who present with different dentofacial disharmonies (DFD) including severe overbites (Class II), underbites (Class III) and anterior open bites. Previous studies have found that patients with these malocclusion types all produce sibilants and plosives with increased spectral center of gravity and increased spectral spread relative to controls. This result is puzzling since some DFD groups differ from controls in opposite ways.