Publications by authors named "D Zadik"
A sexual cycle was described in 2009 for the opportunistic fungal pathogen , opening up for the first time the possibility of using techniques reliant on sexual crossing for genetic analysis. The present study was undertaken to evaluate whether the technique 'bulk segregant analysis' (BSA), which involves detection of differences between pools of progeny varying in a particular trait, could be applied in conjunction with next-generation sequencing to investigate the underlying basis of monogenic traits in . Resistance to the azole antifungal itraconazole was chosen as a model, with a dedicated bioinformatic pipeline developed to allow identification of SNPs that differed between the resistant progeny pool and resistant parent compared to the sensitive progeny pool and parent.
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- The text discusses the impact of Viking migrations to the British Isles, highlighting both archaeological and genetic evidence of their presence.
- Genetic analysis shows that Norse Viking contributions are present in Britain but do not align with the Danelaw region, suggesting a possible male-specific influence.
- Y-chromosome haplogroup R1a1 is identified as linked to Viking migrations, with significant overrepresentation in the Danelaw, indicating a complex interaction between Viking ancestry and British genetics.
Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis.
Arterioscler Thromb Vasc Biol
November 2019
Article Synopsis
- - The study investigates how specific genetic variants in the male-specific region of the Y chromosome (MSY), particularly haplogroup I1, relate to increased risk of coronary artery disease (CAD) among men, finding an 11% higher risk in I1 carriers compared to others.
- - Researchers identified 235 unique genetic variants associated with haplogroup I1, which are linked to vital processes in atherosclerosis, like immune response and lipid metabolism.
- - The findings suggest that haplogroup I1 promotes cardiovascular risk by altering gene expression in crucial pathways linked to atherosclerosis, indicating the MSY's significant role in male cardiovascular health.
Article Synopsis
- Increasing ancient and modern DNA evidence is reshaping interpretations of European prehistory, especially regarding male lineage expansions during the Bronze Age.
- Contrasting findings from Y-chromosome studies and mitochondrial DNA studies highlight a lack of Bronze Age expansion, with more evidence pointing to Paleolithic expansions instead.
- This research emphasizes the difference in demographic transitions based on sex, revealing that recent population changes in Europe were not equally distributed between males and females.
Human genetic diversity in Europe has been extensively studied using uniparentally inherited sequences (mitochondrial DNA (mtDNA) and the Y chromosome), which reveal very different patterns indicating sex-specific demographic histories. The X chromosome, haploid in males and inherited twice as often from mothers as from fathers, could provide insights into past female behaviours, but has not been extensively investigated. Here, we use HapMap single-nucleotide polymorphism data to identify genome-wide segments of the X chromosome in which recombination is historically absent and mutations are likely to be the only source of genetic variation, referring to these as phylogeographically informative haplotypes on autosomes and X chromosome (PHAXs).
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