Evaluation of Thoracic Morphological Changes Using Chest CT in Patients with Congenital Pectus Carinatum Treated by the Modified Abramson Technique.

Background: The Pectus carinatum is an outward protrusion deformity of the sternum and adjacent costal cartilages. It is the second most common congenital deformity of the anterior chest wall, commonly occuring in adolescents.

Objective: The aim of this study was to evaluate thoracic morphological changes using computed tomography (CT) imaging in patients with pectus carinatum treated via the modified Abramson technique at Viet Duc University Hospital from 2020 to 2023.

Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen.

The surge of antimicrobial resistance threatens efficacy of current antibiotics, particularly against Pseudomonas aeruginosa, a highly resistant gram-negative pathogen. The asymmetric outer membrane (OM) of P. aeruginosa combined with its array of efflux pumps provide a barrier to xenobiotic accumulation, thus making antibiotic discovery challenging.

Corrigendum: Effectiveness of perindopril/amlodipine fixed-dose combination in the treatment of hypertension: a systematic review.

[This corrects the article DOI: 10.3389/fphar.2023.

Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics.

The rising prevalence of antibiotic resistance threatens human health. While more sophisticated strategies for antibiotic discovery are being developed, target elucidation of new chemical entities remains challenging. In the postgenomic era, expression profiling can play an important role in mechanism-of-action (MOA) prediction by reporting on the cellular response to perturbation.