Intravitreal melatonin for the prevention of radiation retinopathy: a step beyond bevacizumab.

Purpose: Intravitreal bevacizumab has been utilized to mitigate radiation retinopathy, yet the potential role of intravitreal melatonin for its prevention remains unexplored. This study aims to evaluate and compare the efficacy of intravitreal melatonin and bevacizumab in preventing radiation retinopathy in an experimental animal model.

Materials And Methods: Twelve healthy male New Zealand white rabbits ( = 24 eyes) received a single 3000 cGy irradiation dose in both eyes.

Tracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia.

Tracheal tuft cells shape immune responses in the airways. While some of these effects have been attributed to differential release of either acetylcholine, leukotriene C4 and/or interleukin-25 depending on the activating stimuli, tuft cell-dependent mechanisms underlying the recruitment and activation of immune cells are incompletely understood. Here we show that Pseudomonas aeruginosa infection activates mouse tuft cells, which release ATP via pannexin 1 channels.

Parents' perspective on unplanned return visits to the pediatric emergency department: A cross-sectional study.

Background: The aim of this study was to investigate the factors leading to more than one time visit to the pediatric emergency department within 72 h, parental wishes and experiences with emergency nurses from the parents' perspective.

Material And Methods: A cross-sectional study was conducted between April 15, 2023 and April 14, 2024 with 596 parents of children aged between 0 and 18 years who had return visits to the pediatric emergency department of a gynaecology and pediatrics hospital in the Western Black Sea Region of Türkiye within 72 h after the first visit. Following the acquisition of written informed consent from the parents, the data were collected using the Descriptive Characteristics of Children and Experiences of Parents Information Form.

Evaluating the impact of cardiac substructure dosimetric parameters on survival in lung cancer patients undergoing postoperative radiotherapy.

Purpose: The association of cardiac dosimetric parameters with survival in lung cancer patients is well established. However, most research has concentrated on patients undergoing definitive treatment. This study aims to investigate the relationship between cardiac dosimetric parameters and survival in patients receiving postoperative radiotherapy (PORT).