Publications by authors named "D Yamada"
Background: Opioids are known to induce delirium, and the incidence of delirium induced by individual opioids has been investigated. However, only a limited number of studies have examined the incidence of delirium induced by oral hydromorphone.
Objective: To investigate whether differences exist in the incidence of delirium associated with oral morphine and oral hydromorphone during the initiation phase of treatment.
Purpose: To compare the clinical and radiological features of gastric and small intestinal anisakiasis with those of gastric ulcers and Crohn's disease.
Materials And Methods: In this retrospective cohort study, 205 cases of anisakiasis (148 gastric; 53 small intestinal) were identified between July 2003 and February 2022. The control groups included 130 and 31 patients with gastric ulcers and Crohn's disease, respectively.
Background: Dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (dd-MVAC) regimen has been established as a systemic chemotherapy for patients with urothelial carcinoma. However, it is rarely used in Japan owing to the challenges associated with managing the related adverse events. This study aimed to optimize the dd-MVAC protocol for Japanese patients.
View Article and Find Full Text PDFBackground And Purpose: Irritable bowel syndrome (IBS) is a common condition that is challenging to treat, and novel drugs are needed for this condition. Previously, a chronic vicarious social defeat stress (cVSDS) mouse model exhibits IBS-like symptoms. Also agonists of the opioid δ-receptor exert anti-stress effects in rodents with minimal adverse effects.
View Article and Find Full Text PDFArticle Synopsis
- - The delta opioid receptor (DOP) is identified as a potential target for new antidepressants, as its selective agonist KNT-127 shows promise for rapid antidepressant effects while minimizing side effects.
- - In experiments, KNT-127 reduced behaviors indicative of depression, such as immobility in the forced swimming test and social avoidance in stressed mice, effects that were reversed by inhibitors of mTOR and PI3K pathways.
- - The study suggests that DOP agonists work by enhancing excitatory activity in the medial prefrontal cortex through the PI3K-Akt-mTOR signaling pathway, particularly by reducing GABA release from specific interneurons.