Publications by authors named "D Y Sung"
For successful infection, the life-threatening pathogen Vibrio vulnificus elaborately regulates the expression of survival and virulence genes using various transcription factors (TFs). In this study, a library of the V. vulnificus mutants carrying specific signature tags in 285 TF genes was constructed and subjected to 16 phenotypic analyses.
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- The study aimed to compare the capabilities of GPT-4 and Gemini, two large language models, in analyzing serial radiology reports to identify oncological issues needing clinical attention.
- It involved 205 patients with two consecutive radiological reports and used a three-step task for the LLMs, while two radiologists established a six-level categorization of tumor findings as a ground truth.
- Results indicated that GPT-4 outperformed Gemini in terms of accuracy (96.2% vs 91.7%), precision in identifying tumor-related findings, and correctly determining tumor status, demonstrating the effectiveness of LLMs in oncological surveillance.
Article Synopsis
- Perineural tumor spread (PNTS) to the brachial plexus is a rare condition often occurring years after the initial cancer diagnosis, primarily leading to severe neurological outcomes.
- A study of seven patients revealed that they typically presented with unilateral pain, paresthesia, and eventual motor weakness, with imaging techniques like MRI and PET/CT showing significant abnormalities in the brachial plexus.
- Despite attempts at treatment, the prognosis was poor, with six out of seven patients dying within 19 months of PNTS diagnosis, highlighting the need for heightened awareness and comprehensive imaging for early detection.
Peptide-based prodrugs, such as peptide-drug conjugates (PDCs), are currently being developed for cancer therapy. PDCs are considered single-component nanomedicines with various functionalities. The peptide moieties provide stability to the PDCs, which self-assemble into nanostructures in an aqueous medium.
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