Publications by authors named "D Y Sia"
Background: Healthcare-associated infections (HCAI) are common in long-term care facilities (LTCF) and cause significant burden. Infection prevention and control (IPC) measures include the clinical best practices (CBP) of hand hygiene, hygiene and sanitation, screening, and basic and additional precautions. Few studies demonstrate their cost-effectiveness in LTCF, and those that do, largely focus on one CBP.
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- Research shows that mammary gland aging can happen in cycles influenced by maternal ancestry, rather than just gradually over time.
- In these cycles, mouse mammary glands at 11 and 19 months show similarities related to cancer, while younger glands (3 and 14 months) do not, potentially explaining why breast cancer peaks around these ages.
- The study suggests that if harmful mutations in cells are avoided during the more vulnerable aging phases, rejuvenation might help delay cancer and could lead to longer lifespans in mice.
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- TGF-β is implicated in promoting cancer development, and the study investigates a specific protein's role in hepatocellular carcinoma (HCC), finding its overexpression linked to aggressive cancer features.
- The research involved analyzing tumor data from a large number of HCC patients and using mouse models to explore molecular effects, revealing a connection between the protein’s levels and immune system suppression.
- The findings suggest that overexpressing this protein contributes to tumor growth and poor patient outcomes, highlighting its potential as a target for cancer treatment.
Cholangiocarcinomas are a highly heterogeneous group of malignancies that, despite recent progress in the understanding of their molecular pathogenesis and clinical management, continue to pose a major challenge to public health. The traditional view posits that cholangiocarcinomas derive from the neoplastic transformation of cholangiocytes lining the biliary tree. However, increasing genetic and experimental evidence has recently pointed to a more complex, and nuanced, scenario for the potential cell of origin of cholangiocarcinomas.
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