Enhancement of prefrontal functional connectivity under the influence of concurrent physical load during mental tasks.

Backgrounds: Functional near-infrared spectroscopy (fNIRS) is widely used for the evaluation of mental workload (MWL), but it is not yet clear whether it is affected by physical factors during cognitive tasks. Therefore, the combined effects of physical and cognitive loads on hemodynamic features in the prefrontal cortex were evaluated.

Methods: Thirty-three eligible healthy male subjects were asked to perform three types of cognitive tasks (1-back, 2-back and 3-back).

Efficacy of opioid combination versus single opioid for adult cancer pain: a protocol for systematic review and meta-analysis.

Introduction: Chronic pain is one of the most common and serious symptoms of cancer. Despite the limitations of dose titration using only one type of opioid, the effects of opioid combinations are poorly understood.

Methods And Analysis: This study will be conducted in accordance with the Cochrane Handbook of Systematic Reviews of Interventions 6.

The human glucocorticoid receptor variant rs6190 promotes blood cholesterol and atherosclerosis.

Elevated cholesterol poses a significant cardiovascular risk, particularly in older women. The glucocorticoid receptor (GR), a crucial nuclear transcription factor that regulates the metabolism of virtually all major nutrients, harbors a still undefined role in cholesterol regulation. Here, we report that a coding single nucleotide polymorphism (SNP) in the gene encoding the GR, , associated with increased cholesterol levels in women according to UK Biobank and All Of Us datasets.

Invasive Group B Streptococcus Infections Caused by Hypervirulent Clone of S. agalactiae Sequence Type 283, Hong Kong, China, 2021.

During September-October 2021, group B Streptococcus bloodstream infections surged among patients hospitalized in Hong Kong. Of 95 cases, 57 were caused by the hypervirulent strain sequence type 283, which at the time was also found in freshwater fish and wet market environments and thus poses a transmission threat.