Publications by authors named "D Y Hironaka"
Article Synopsis
- Triple-negative breast cancer (TNBC) is a challenging type of breast cancer without specific treatment targets, primarily relying on traditional chemotherapy methods, making it essential to explore new therapeutic strategies.
- Researchers engineered extracellular vesicles (EVs) using RNA nanotechnology to deliver targeted therapies specifically to TNBC cells by optimizing them with survivin small interfering RNA (siRNA) and CD44 aptamer ligands.
- The study found that these engineered EVs dramatically reduced the required doses of chemotherapy drugs like gemcitabine and paclitaxel, showing effective tumor growth inhibition while potentially minimizing side effects associated with standard chemotherapy treatments.
Telomere biology disorders (TBDs), caused by pathogenic germ line variants in telomere-related genes, present with multiorgan disease and a predisposition to cancer. Clonal hematopoiesis (CH) as a marker of cancer development and survival in TBDs is poorly understood. Here, we characterized the clonal landscape of a large cohort of 207 patients with TBD with a broad range of age and phenotype.
View Article and Find Full Text PDFObjectives: Ageing and inflammation are associated with clonal haematopoiesis (CH), the emergence of somatic mutations in haematopoietic cells. This study details CH in patients with systemic vasculitis in association with clinical, haematological and immunological parameters.
Methods: Patients with three forms of vasculitis were screened for CH in peripheral blood by error-corrected sequencing.
Article Synopsis
- VEXAS syndrome is a health condition caused by changes in a gene called UBA1, leading to serious inflammation and issues with blood cells.
- Researchers studied 80 patients to understand how other gene mutations relate to VEXAS, finding that many had additional mutations but these didn’t seem to cause inflammation.
- The study showed that the type of mutations these patients have can affect their health outcomes, with some patterns linked to better or worse survival rates over 10 years.
Vision impairments are highly prevalent after acquired brain injury (ABI). Conceptual models that focus on constructing intellectual frameworks greatly facilitate comprehension and implementation of practice guidelines in an interprofessional setting. The purpose of this article is to provide a review of the vision literature in ABI, describe a conceptual model for vision rehabilitation, explain its potential clinical inferences, and discuss its translation into rehabilitation across multiple practice settings and disciplines.
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