Piperidine and bis-piperidine alkaloids from the peels of Areca catechu and their monoamine oxidases inhibitory activity.

Eleven undescribed piperidine alkaloids, arecachines A‒J (1‒11), were isolated from the peels of Areca catechu. Compounds 8‒11 are featured as bis-piperidine alkaloids. Their structures were elucidated by analysis of UV, IR, HRESIMS, 1D and 2D NMR spectra.

Developing a Ni-grafted magnetic nanoparticle for direct CotA capture in rapid detoxification of aflatoxin B1.

Aflatoxin B1 (AFB1) exposure often causes serious food safety problems and illnesses in humans and animals, even at extremely low content. Therefore, effective degradation of AFB1 is vitally significant. Biodegradation by enzymes is an effective method to eliminate hazardous toxins, but the degradation efficiency and cost of the enzyme limit its wide application.

Comparative Efficacy and Safety of Different Low-Dose Platelet Inhibitors in Patients With Coronary Heart Disease: A Bayesian Network Meta-Analysis.

Objective: The optimal low-dose antiplatelet agents in patients with coronary heart disease (CHD) had not been determined. The objective of this study was to compare the impact of different low-dose antiplatelet agents on cardiovascular outcomes and bleeding risks in patients with CHD.

Methods: We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, VIP, WanFang Data, and China Biology Medicine.

Systolic blood pressure modifies the effect of endovascular thrombectomy in acute ischemic stroke: a mediation analysis.

Background: Systolic blood pressure (BP) is a key factor in the outcomes of patients with acute ischemic stroke (AIS) receiving endovascular thrombectomy (EVT). However, the factors that mediate the association between BP and clinical outcome are unclear.

Methods: Consecutive patients with AIS in the anterior circulation underwent continuous blood pressure monitoring for 24 hours.

The Prevalence and Related Factors of Hearing Loss Among Adults: A Systematic Review and Meta-Analyses.

Objectives: We aimed to estimate the global prevalence of hearing loss among adults and to explore its associated factors.

Methods: Our systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement (PRISMA). We retrieved corresponding documents published up to Sep 24, 2021 in PubMed and Web of Science.