Publications by authors named "D Wypij"
: While it is generally assumed that common neurobehavioral assessments, such as the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV), function similarly in clinical and non-clinical populations, this has not been validated in adults with congenital heart disease (CHD). In this study, we examined the latent factor structure of the WAIS-IV in adults with d-transposition of the great arteries (d-TGA) who participated in the Boston Circulatory Arrest Study. : The WAIS-IV was administered as part of a larger assessment battery.
View Article and Find Full Text PDFBackground: While subject coenrollment into multiple trials is desirable, thoughtful consideration is required to avoid compromising each trial's scientific integrity.
Objective: We developed a Decision-Making Grid (GRID) to help investigators determine whether a clinical trial is compatible with a second clinical trial, thus allowing coenrollment, or if it should be considered competing, prohibiting coenrollment.
Methods: The GRID evaluates 21 elements across 4 domains: Scientific Integrity, Data Interpretation, Feasibility/Burden, and Additional Considerations.
Importance: Data are limited on the longitudinal implications of socioeconomic status (SES) for neurodevelopmental outcomes among persons with complex congenital heart disease (CHD).
Objectives: To examine the association of family SES, maternal educational level, and maternal IQ with the neurodevelopment of individuals with dextro-transposition of the great arteries (d-TGA) from age 1 to 16 years and to identify how SES-related disparities change with age.
Design, Setting, And Participants: This cohort study analyzed data of participants enrolled in the Boston Circulatory Arrest Study, a randomized clinical trial conducted in Boston, Massachusetts, from 1988 to 1992.
Article Synopsis
- Continuous glucose monitoring (CGM) combined with geriatric-focused treatment can effectively reduce hypoglycemia in older adults with type 1 diabetes without harming overall blood sugar control.
- A study involving older adults with a history of hypoglycemia found significant reductions in time spent with low blood sugar in those using CGM and tailored treatment versus traditional care.
- The intervention proved cost-effective, with a cost of $71,623 per quality-adjusted life-year, suggesting it offers good value for enhancing the health of this patient group.
The Nurse-Implemented Chronotherapeutic Bundle in Critically Ill Children, RESTORE Resilience (R 2 ): Pilot Testing in a Two-Phase Cohort Study, 2017-2021.
Pediatr Crit Care Med
November 2024
Article Synopsis
- The study aimed to pilot test a nurse-led chronotherapeutic bundle (RESTORE Resilience R 2) in critically ill children on mechanical ventilation from 2017 to 2021 across two PICUs in the U.S.
- The intervention involved a seven-item bundle focusing on replicating the child's daily routine, modulating environmental light and sound, providing minimal sedation, and promoting early mobility, with notable improvements in compliance during the intervention phase.
- Results showed a significant increase in daytime activity consolidation post-extubation, although some components, like nursing care continuity and parent diaries, saw little change.